Molecular Biology in Burns and Trauma

描述（由申请人提供）：这个露丝Kirschstein NRSA培训计划在其第14年提出，在他们的一般住院医师计划的第二年或第三年，主要采取外科医生和其他重症监护医学医生，并使他们接触到两个，三个甚至四年的指导研究炎症生物学与高生产力的基础科学导师专注于炎症相关的主题。整个研究计划将侧重于掌握分子生物学，功能基因组学和基因调控，因为它广泛适用于炎症研究。请求设立三个培训职位。该计划将利用医学院在功能基因组学和分子生物学领域的独特优势，以及致力于培养未来临床院士的基础科学家和临床医生之间的合作。选定的学员将拥有 完成博士学位的机会在研究生院的计划在三到四年。分子生物学和炎症研究之间的接口将针对创伤，脓毒症综合征，缺血/再灌注损伤，血管损伤，延迟伤口愈合和烧伤伤口。 教师将从外科，医学，病理学，牙周病学，分子遗传学和微生物学部门的基础科学家中选出，他们将担任学员的研究导师。 来自外科，内科和病理学部门的临床导师将与学员和研究人员互动，以确保学员接触到炎症研究中的临床重要问题。 该计划的总体方向将取决于计划主任和执行委员会。 该研究金的候选人将在全国范围内和从佛罗里达大学医学院招募。执行委员会的成功申请者将确定一名研究和临床导师，他将帮助制定正式的培训计划并定期审查受训者的进展。 培训计划的大部分将在一位经验丰富的研究导师的实验室进行，但学员也将被要求完成研究伦理学的基本课程工作。 和统计方法，并将鼓励获得补充教学分子生物学培训。 此外，受训人员还将参加新出现病原体研究所和遗传学研究所的基础科学研讨会，以及他们自己的基础科学部门的研讨会和实验室研究会议。 他们还将参加临床研讨会，包括外科和重症监护医学大圆桌会议和外科学术研究会议的部门。 预计成功的毕业生将拥有足够的研究技能，以竞争炎症研究的过渡资金。

DESCRIPTION (provided by applicant): This Ruth Kirschstein NRSA training Program in its 14th year proposes to take primarily surgeons and other critical care medicine physicians during the second or third year of their general residency programs, and expose them to two, three and even four years of mentored research in inflammation biology with highly productive basic science mentors focused on inflammation-related topics. The overall research program will focus on mastery of molecular biology, functional genomics and gene regulation, as it applies broadly to inflammation research. Three training positions are requested. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of functional genomics and molecular biology, as well as the collaborations between basic scientists and clinicians committed to the training of future clinical academicians. Select trainees will have the opportunity to complete a Ph.D. program in the Graduate School in three to four years. The interface between molecular biology and inflammation research will be targeted to trauma, sepsis syndromes, ischemia/reperfusion injury, vascular injury, delayed wound healing and the burn wound. The faculty will be drawn from funded basic scientists in the Surgery, Medicine, Pathology, Periodontology, and Molecular Genetics and Microbiology Departments, who will serve as research mentors to the trainees. Clinical mentors from the Surgery, Medicine and Pathology Departments will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Program Director and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine. Successful applicants with the Executive Committee will identify a research and clinical mentor who will help formulate a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology. Furthermore, trainees are expected to participate in basic science seminars in the Emerging Pathogens Institute and Genetics Institute, and in their own basic science departments, as well as laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds and the Department of Surgery Academic Research Conference. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research.