HIGH THROUGHPUT BIODOSIMETRY USING A FULLY AUTOMATED DICENTRIC ASSAY ON COMMERCIAL HIGH-CONTENT SCREENING PLATFORMS

在商业高内涵筛选平台上使用全自动双着丝粒测定进行高通量生物剂量测定

• 批准号: 9365080
• 负责人: GUY GARTY
• 金额: $ 158.39万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2019-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9365080
• 关键词: Acute; Affect; Biological Assay; Blood; Blood donor; Devices; Diagnostic Procedure; Dicentric chromosome; Dose; Earthquakes; Event; Food Supply; Individual; Japan; Location; Manuals; Medical; Methods; Natural Disasters; Nuclear; Nuclear Power Plants; Nuclear Weapon; Organ; Patients; Performance; Preparation; Process; Radiation; Radiation Injuries; Radiation therapy; Sampling; Signal Transduction; Source; System; Terrorism; Theft; Tissues; Tsunami; Water Supply; biodosimetry; dirty bomb; reconstruction; screening

Over the last two decades world events have highlighted the growing threat of terrorism and its many forms that include radiological/nuclear weapons. Acts of radiological or nuclear terrorism could involve the use of stolen or improvised nuclear devices, attacks on nuclear power plants or reactors, the detonation of a dirty bomb, or the placement of radiation sources in public locations or in food or water supplies. Moreover, natural disasters like the 2011 earthquake and tsunami in Japan further emphasize the need for methods to assess radiation exposure of individuals and stockpile medical countermeasures (MCMs) to administer in the event of a radiation incident. Because estimates of radiation exposure dose alone will not necessarily predict the extent of radiation injury to organs and tissues, there is a need for rapid, accurate and sensitive assays/techniques and diagnostic platforms that can confirm exposure and predict acute and delayed radiation injury to different organs and tissues in victims of radiation incidents.

过去二十年来，世界上发生的事件突出表明，恐怖主义及其包括放射性/核武器在内的多种形式的威胁日益严重。放射性或核恐怖主义行为可能涉及使用被盗或简易的核装置、攻击核电站或反应堆、引爆脏弹或在公共场所或食品或供水中放置辐射源。此外，2011年日本地震和海啸等自然灾害进一步突出表明，需要有评估个人辐射照射的方法，并储备在发生辐射事件时实施的医疗对策。由于仅对辐射照射剂量的估计不一定能预测器官和组织的辐射损伤程度，因此需要快速、准确和灵敏的化验/技术和诊断平台，以确认照射并预测辐射事件受害者不同器官和组织的急性和延迟辐射损伤。