HIGH THROUGHPUT BIODOSIMETRY USING A FULLY AUTOMATED DICENTRIC ASSAY ON COMMERCIAL HIGH-CONTENT SCREENING PLATFORMS

过去二十年来，世界事件突出表明，恐怖主义及其包括放射性/核武器在内的多种形式的威胁日益严重。放射性或核恐怖主义行为可能涉及使用偷来的或简易的核装置，袭击核电站或反应堆，引爆脏弹，或在公共场所或食物或水供应中放置放射源。此外，2011年日本地震和海啸等自然灾害进一步强调，需要制定评估个人辐射暴露的方法，并储备医疗对策，以便在发生辐射事件时进行管理。由于单独估计辐射照射剂量不一定能预测对器官和组织的辐射损伤程度，因此需要快速、准确和敏感的分析/技术和诊断平台，以确认辐射照射并预测辐射事件受害者不同器官和组织的急性和延迟辐射损伤。

Over the last two decades world events have highlighted the growing threat of terrorism and its many forms that include radiological/nuclear weapons. Acts of radiological or nuclear terrorism could involve the use of stolen or improvised nuclear devices, attacks on nuclear power plants or reactors, the detonation of a dirty bomb, or the placement of radiation sources in public locations or in food or water supplies. Moreover, natural disasters like the 2011 earthquake and tsunami in Japan further emphasize the need for methods to assess radiation exposure of individuals and stockpile medical countermeasures (MCMs) to administer in the event of a radiation incident. Because estimates of radiation exposure dose alone will not necessarily predict the extent of radiation injury to organs and tissues, there is a need for rapid, accurate and sensitive assays/techniques and diagnostic platforms that can confirm exposure and predict acute and delayed radiation injury to different organs and tissues in victims of radiation incidents.