HIGH THROUGHPUT BIODOSIMETRY USING A FULLY AUTOMATED DICENTRIC ASSAY ON COMMERCIAL HIGH-CONTENT SCREENING PLATFORMS

在商业高内涵筛选平台上使用全自动双着丝粒测定进行高通量生物剂量测定

• 批准号: 9365080
• 负责人: GUY GARTY
• 金额: $ 158.39万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2019-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9365080
• 关键词: Acute; Affect; Biological Assay; Blood; Blood donor; Devices; Diagnostic Procedure; Dicentric chromosome; Dose; Earthquakes; Event; Food Supply; Individual; Japan; Location; Manuals; Medical; Methods; Natural Disasters; Nuclear; Nuclear Power Plants; Nuclear Weapon; Organ; Patients; Performance; Preparation; Process; Radiation; Radiation Injuries; Radiation therapy; Sampling; Signal Transduction; Source; System; Terrorism; Theft; Tissues; Tsunami; Water Supply; biodosimetry; dirty bomb; reconstruction; screening

Over the last two decades world events have highlighted the growing threat of terrorism and its many forms that include radiological/nuclear weapons. Acts of radiological or nuclear terrorism could involve the use of stolen or improvised nuclear devices, attacks on nuclear power plants or reactors, the detonation of a dirty bomb, or the placement of radiation sources in public locations or in food or water supplies. Moreover, natural disasters like the 2011 earthquake and tsunami in Japan further emphasize the need for methods to assess radiation exposure of individuals and stockpile medical countermeasures (MCMs) to administer in the event of a radiation incident. Because estimates of radiation exposure dose alone will not necessarily predict the extent of radiation injury to organs and tissues, there is a need for rapid, accurate and sensitive assays/techniques and diagnostic platforms that can confirm exposure and predict acute and delayed radiation injury to different organs and tissues in victims of radiation incidents.

在过去的二十年中，世界事件强调了恐怖主义及其包括放射学/核武器在内的许多形式的威胁。放射学或核恐怖主义的行为可能涉及使用被盗或简易的核装置，对核电站或反应堆的攻击，肮脏的炸弹的爆炸或放射源在公共场所或食品或供水中的放射源。此外，诸如日本2011年地震和海啸之类的自然灾害进一步强调了在辐射事件发生的情况下，需要评估个人和库存医疗对策（MCMS）的方法。由于仅对辐射暴露剂量的估计不一定会预测对器官和组织的辐射损伤程度，因此需要快速，准确，敏感和敏感的测定法/技术和诊断平台，以确认暴露并预测辐射事件受害者中不同器官和组织的急性和延迟辐射损伤。