Animal Reagent and Immune Function Core

动物试剂和免疫功能核心

• 批准号: 9090076
• 负责人: Sangeeta S. Chavan
• 金额: $ 44.05万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9090076
• 关键词: Address; Animal Model; Animals; Antibodies; Breeding; Cause of Death; Cognitive; Cognitive deficits; Data; Diamond; Endotoxins; Immune; Impairment; Inflammation; Instruction; Intervention; Ligation; Modality; Monoclonal Antibodies; Mouse Strains; Mus; Neurophysiology - biologic function; Operative Surgical Procedures; Patients; Pharmaceutical Preparations; Prevention; Principal Investigator; Proteins; Protocols documentation; Public Health; Puncture procedure; Reagent; Recombinant Cytokines; Recombinants; Research Project Grants; Resources; Sepsis; Services; Survivors; TNF gene; Testing; Therapeutic; Time; United States; cognitive function; cytokine; experience; immune function; neutralizing antibody; programs; research study; sham surgery; vagus nerve stimulation

Animal Model Reagent, and Immune Function - Core B Severe sepsis is a major public health problem, because it is the leading cause of death in hospitalized patients in the United States, and one of the ten leading causes of death in the developed world. Seventy percent of the sepsis patients survive, but often do not return to their premorbid condition. Recent evidence indicates that sepsis survivors experience cognitive and immune impairment, and more than half of the survivors die within 5 years. The Animal, Reagent and Immune Function Core will provide a centralized resource for performing animal surgeries, generating cytokine and antibody reagents, and overseeing immune function assessment tests. Use of these animal models and reagents in studies proposed here will provide significant data that can be used to modulate neural and immune function to develop therapeutic modalities for the prevention and treatment of sepsis induced cognitive and immune impairments. RELEVANCE (See instructions); This Core will help in mouse surgery and in tests of immune function. It will produce cytokines and antibodies for all research projects.

动物模型试剂和免疫功能-核心B 严重脓毒症是一个重大的公共卫生问题，因为它是住院患者死亡的主要原因 在美国的患者中，并且是发达国家的十大死亡原因之一。七十 %的脓毒症患者存活，但通常不会恢复到发病前的状态。最近的证据 表明脓毒症幸存者经历认知和免疫功能障碍，超过一半的 幸存者在5年内死亡。动物、试剂和免疫功能核心将提供集中的 用于进行动物外科手术、生成细胞因子和抗体试剂以及监督 免疫功能评估测试。在本文提出的研究中使用这些动物模型和试剂将 提供了可用于调节神经和免疫功能以开发治疗药物的重要数据。 用于预防和治疗脓毒症引起的认知和免疫损伤的方式。 相关性（参见说明）; 这种核心将有助于小鼠手术和免疫功能测试。它会产生细胞因子和抗体 所有研究项目。