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Decision confidence: neural coding and causal circuit mechanisms in behavior

决策信心：行为中的神经编码和因果回路机制

基本信息

批准号：
9052835
负责人：
Adam Kepecs
金额：
$ 48万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9052835
关键词：
Affect Animals Anxiety Architecture Area Attention Autistic Disorder Behavior Behavioral Behavioral trial Brain Brain region Code Computer Simulation Data Decision Making Electrophysiology (science)Environment Gambling Goals Health Heart Heterogeneity Human Impairment Investigation Judgment Lead Learning Left Light Link Mediating Mental Depression Mental disorders Methods Modeling Motor Neural Pathways Neurons Neurosciences Obsessive-Compulsive Disorder Odors Optics Organism Outcome Pathway interactions Play Population Prefrontal Cortex Primates Probability Process Property Psychometrics Psychophysics Rattus Reporting Rewards Rodent Role Route Schizophrenia Signal Transduction Source Staging System Task Performances Testing Time Uncertainty Viral Virus Work addiction anatomical tracing base cell cortex cell type computer framework improved indexing information seeking behavior insight loss of function metacognition neural circuit neural correlate neuromechanism neuropsychiatric disorder neuropsychiatry novel operation optogenetics outcome prediction relating to nervous system response tool

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of our investigation is to understand how neural circuits in the prefrontal cortex support decision-making. Orbitofrontal cortex (OFC) is a key brain region for decision- making under uncertainty in humans and other animals. Our central hypothesis is that OFC represents confidence information and plays causal role in reporting decision confidence to other brain regions, thereby affecting behavior. To study this issue, we have developed quantitative psychophysical methods for rodents, adapted from human and primate work, which enables the behavioral readout of confidence in a well-controlled decision task. Briefly, in each trial the animal has to decide which of two odor components is in the majority. After moving to the corresponding choice port, the rat waits for a delayed reward that may or may not come. If it doesn't, the rat eventually leaves the port and initiates another trial. The duration rats are willing to wait for a reward can be thought of as a gamble on the outcome of the perceptual decision, and hence it provides a quantitative index for confidence. Thus in each trial there is a perceptual decision (left/right) and a post-decision confidence report (leaving decision). If OFC is causal in this leaving decision, neural activity should be predictive of how long a rat waits before leaving on a trial-by-trial basis (correlation) We will also test the necessity of OFC activity for this process using pharmacological inactivation. These results will be interpreted in a computational framework that links neural and behavioral data to decision confidence. Next we will test the hypothesis that identified subsets of OFC neurons projecting to distinct target areas carry different types of information and thus mediate distinct behavioral functions. Using retrograde viruses to deliver light-sensitive activators (ChR2) and suppressors (Halo), we will optically microstimulate or block a subset of OFC neurons defined not by spatial proximity but by projection target. In combination with electrophysiology we will identify the neural correlates of distinct projection neurons and determine whether they are necessary and sufficient for confidence reports on a trial-to-trial basis. Upon completion of these aims, we expect to establish the role of OFC in decision confidence and determine the neural circuits through which it exerts its actions. By recording from neurons belonging to different long-range projections we also expect to help explain the observed heterogeneity in OFC neural representations. Beyond these mechanistic studies, we hope to inform an improved framework for understanding how impairments in a single prefrontal brain area can lead to such a wide range of psychiatric disorders, including addiction, depression, anxiety, obsessive-compulsive disorder, schizophrenia, and autism.

描述（由申请人提供）：我们研究的长期目标是了解前额皮质中的神经回路如何支持决策。眼窝额叶皮层（OFC）是人类和其他动物在不确定情况下做出决策的关键脑区。我们的中心假设是OFC代表信心信息，并在向其他脑区报告决策信心方面发挥因果作用，从而影响行为。研究