Engaging students in diabetic kidney disease: An Interactive inquiry approach

描述（由申请人提供）：糖尿病是一种在美国具有巨大健康意义的疾病，也是肾脏疾病的最常见原因。NIDDK在努力更好地了解和治疗这些疾病方面发挥着至关重要的作用， 创新的基础和应用研究项目。然而，越来越多的证据表明，NIDDK未来的成功将受到进入生物医学研究职业的学生数量的限制。这个为期五年的项目是我们长期目标的一部分，即刺激美国学生考虑从事科学职业。这个项目的目标是创建和严格评估课程材料，利用高品质的3D创新组合 动画和视频游戏引擎技术，让学生参与肾脏疾病的病理生理学和用于研究糖尿病对肾脏影响的研究模型。在这个项目中，我们将开发脚手架，探究为基础的课程材料，将从事今天的技术精明的本科生，培养科学的思维习惯，并鼓励学生考虑在生物医学研究的职业生涯。在这个项目中创建的探究式学习活动将使学生了解正常肾功能的基础过程以及糖尿病导致的变化，特别是导致系统性高血压和肾衰竭的发展。学生探索健康和糖尿病中肾功能的基本方面的机会将通过创建两个互动案例研究得到进一步加强。将在本项目中开发和评估的案例研究包括突出糖尿病引起的肾脏疾病的临床影响的临床案例研究，以及学生将模拟糖尿病实验模型的研究案例研究。这些案例研究将旨在促进科学家特有的思维习惯的发展，即进行观察，发展和测试假设，收集，分析和解释数据，并得出结论。综合课程材料和互动案例研究将被严格评估，以评估其对学生成绩和生物医学研究兴趣的影响。在这样做的过程中，我们将有助于NIDDK的核心使命，提高学生对这些疾病过程的理解，并鼓励学生考虑在疾病为导向的生物医学研究的职业生涯。

DESCRIPTION (provided by applicant): Diabetes is a disease of enormous health significance in the US and is also the most common cause of kidney disease. The NIDDK plays a crucial role in efforts to better understand and treat these diseases by fostering and supporting innovative basic and applied research projects. However, converging lines of evidence indicate that NIDDK's future success will be limited by the paucity of students entering careers in biomedical research. This five-year project is a component of our long-term goal of stimulating US students to consider careers in science. The objectives of this project are to create and rigorously evaluate curricular materials that utilize an innovative combination of high quality 3-D animations and videogame engine technologies to engage students in the pathophysiology of kidney disease and the research models used to study the renal effects of diabetes. In this project, we will develop scaffolded, inquiry-based curricular materials that will engage today's technology-savvy undergraduate students, cultivate scientific habits of mind, and encourage students to consider careers in biomedical research. The inquiry-based learning activities created in this project will expose students to the processes that underlie normal renal function and the changes that occur as the result of diabetes, particularly those that result in the development of systemic hypertension and kidney failure. The opportunities for students to explore the fundamental aspects of kidney function in health and diabetes will be further enhanced by the creation of two interactive case studies. The case studies that will be developed and evaluated in this project include a clinical case study highlighting the clinical effects of diabetes-induced kidney disease, and a research case study in which the students will simulate experimental models of diabetes. These case studies will be designed to promote the development of the habits of mind that characterize scientists, namely making observations, developing and testing hypotheses, collecting, analyzing and interpreting data, and drawing conclusions. The integrative curricular materials and interactive case studies will be rigorously evaluated to assess their impact on student achievement and interest in biomedical research as a possible career. In doing so, we will contribute to NIDDK's core mission by improving student understanding of these disease processes and encouraging students to consider careers in disease-oriented biomedical research.