Imaging and Biomarkers in Adolescents Cleared for Return to Play After Concussion

描述(由申请人提供)：这项前瞻性的观察性研究解决了主要假设，即无症状的高中运动员在运动后一个月发生脑震荡(SC)时存在脑功能障碍和结构性损伤，这些运动员已被有执照的健康提供者(LHP)批准重返赛场(RTP)。我们假设，在招募当天从血清中测量的生物标记物是SC术后一个月恢复的预测。高中运动员将在毕业后三天内从连续转介到休斯顿的纪念赫尔曼运动医学诊所招募(n=24)。24名患有骨科损伤(OI)的高中运动员也将被招募为对照组。每周通过电话对脑震荡后症状进行评估，将在一个月内确定没有症状并允许进行RTP的运动员。伤后1个月，两组均复诊进行神经行为评估、磁共振成像(MRI)、弥散张量成像(DTI)和静息状态功能磁共振成像(FC)。数据分析将测试脑白质束完整性(DTI)和脑区FC的组间差异。将分析生物标记物水平与 SC组1个月后对脑成像和神经行为恢复的影响。

DESCRIPTION (provided by applicant): This prospective, observational study addresses the overarching hypothesis that brain dysfunction and structural injury are present at one month post- sports concussion (SC) in asymptomatic high school athletes who have been cleared by a licensed health provider (LHP) for return to play (RTP). We hypothesize that a biomarker measured from serum on the day of recruitment is prognostic of recovery by one month post-SC. High school athletes will be recruited within three days post-SC (n=24) from consecutive referrals to Memorial Hermann Sports Medicine Clinic in Houston. A comparison group of 24 high school athletes with orthopedic injury (OI) will also be recruited. Weekly assessment via telephone of post-concussion symptoms will identify athletes who are asymptomatic by one month and cleared for RTP. At one month post-injury both groups will return to clinic for neurobehavioral assessment, magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and resting state functional magnetic resonance imaging to measure functional connectivity (FC) of brain regions. Data analysis will test between-group differences in integrity of white matter tracts (DTI) and FC of brain regions. Biomarker levels will be analyzed in relation to brain imaging and neurobehavioral recovery at one month in SC group.