Waisman Intellectual and Developmental Disabilities Research Center

我们寻求韦斯曼中心智力和发育障碍研究的持续支持 中心，一个全面的跨学科计划，专注于IDD跨越生物，生物行为，和 生物行为科学。韦斯曼国际数据中心汇集了来自21个学术部门的46名PI 威斯康星大学麦迪逊分校医学与公共卫生、兽医、药学、农业与生活学院 科学、文学和科学、教育、工程和人类生态学。此应用程序请求 支持行政核心(核心A)，提供科学的领导、计划和教师发展， 促进跨学科协作以及生物统计和生物信息学专门知识；以及三项创新 科学核心服务：临床翻译(核心B)，提供服务、资源和培训 招募人类参与者、临床评估、行为方法开发和cGMP 治疗学的生物制造；脑成像(核心C)，提供最先进的神经成像 仪器设备(用于人类、非人类灵长类和啮齿动物扫描的3T MRI、PET和MicroPET扫描仪， 和脑电记录系统)，以及用于图像采集和分析的专门知识和工具；以及IDD 模型(核心D)，在生成和表征方面提供资源、专业知识和技术服务 在小鼠和大鼠的突变或基因工程菌株中，诱导多能干细胞的产生 来自患有IDD的人类的品系，以及用于这些模型的表型表征的设施 分子、细胞和行为技术。此外，我们请求支持一个研究项目，该项目是 重点研究了FMR1基因CGG重复长度的变化对健康和功能的影响 通过生物水平的细胞，使用细胞培养模型和人类受试者。 我们建议为由46名私人投资主任领导的79个研究项目提供核心支援，这些项目涉及三大主题 与IDD相关的：1)神经系统发育和发病机制，2)IDD状况，3)评估， 干预措施和治疗学。集中韦斯曼中心的核心服务和研究项目 IDDRC将促进新的跨学科IDD研究，并加强现有的IDD调查 我们的重点是发现、预防和治疗IDD疾病，并改善 碘缺乏病患者及其家属。

We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research Center, a comprehensive interdisciplinary program focused on IDD spanning the biological, biobehavioral, and bio-behavioral sciences. The Waisman IDDRC brings together 46 PIs from 21 academic departments from the UW-Madison's Schools of Medicine and Public Health, Veterinary Medicine, Pharmacy, Agriculture and Life Sciences, Letters and Science, Education, Engineering, and Human Ecology. This application requests support for an Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of interdisciplinary collaboration, and biostatistical and bioinformatics expertise; and three innovative scientific core services: Clinical Translational (Core B), providing services, resources, and training in the recruitment of human participants, clinical assessment, behavioral methods development, and cGMP biomanufacturing of therapeutics; Brain Imaging (Core C), providing access to state-of-the-art neuroimaging instrumentation (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning, and an EEG recording system), as well as expertise and tools for image acquisition and analysis; and IDD Models (Core D), providing resources, expertise, and technical services in the generation and characterization of mutant or genetically engineered strains of mice and rats, the generation of induced pluripotent stem cell lines from humans with IDD conditions, and facilities for phenotypic characterization of these models using molecular, cellular and behavioral technologies. In addition, we request support for a Research Project that is focused on the impact of variations in CGG repeat length in the FMR1 gene on health and function at the cellular through organismal level, using both cell culture models and human subjects. We propose to provide core support to 79 research projects headed by 46 PIs addressing three broad themes relevant to IDD: 1) nervous system development and pathogenesis, 2) IDD conditions, and 3) assessment, interventions, and therapeutics. Collectively the core services and the research project of the Waisman Center IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations sharpening our focus on discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of individuals with IDD and their families.