RODENT MODELS CORE

啮齿动物模型核心

• 批准号: 7907929
• 负责人: ALBEE MESSING
• 金额: $ 33.23万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907929
• 关键词: Achievement; Animals; Behavioral; Caring; Central Nervous System Diseases; Consultations; Cryopreservation; Data Analyses; Developmental Disabilities; Engineering; Equipment; Future; Generations; Guidelines; Knock-out; Laboratories; Laboratory Animals; Location; Maintenance; Mental Retardation; Mental Retardation and Developmental Disabilities Research Centers; Modeling; Mouse Strains; Mus; Neurodegenerative Disorders; Phenotype; Publications; Quality of Care; Rattus; Research; Research Personnel; Research Project Grants; Resources; Rodent; Rodent Model; Services; Training; Transgenic Organisms; Universities; Wisconsin; behavior test; cost; data sharing; design; feeding; member; model development; mutant; novel; research study

INTRODUCTION The Rodent Models Core provides technical support for the generation and characterization of transgenic and knockout strains of mice, access to expensive behavioral equipment for mice and rats that can be shared among several investigators, and expertise in the behavioral phenotyping of mouse and rat models of MRDD and related disorders of the CNS. In addition, the Core is responsible for the care, feeding, and recordkeeping related to the use of mice and rats by MRDDRC projects and the maintenance of specific rodent models of development, developmental disabilities, and neurodegenerative diseases. This Core has been renamed during the present project period, reflecting a sharpening of its focus and considerable new expertise and services added during the past five years in order to be both responsive to the growing and changing needs of MRDDRC investigators and to contribute to the evolving scientific agenda of the MRDDRC. The space allocated to this Core is in the midst of a major renovation that, as of January 2005, resulted in the temporary relocation of all animals to other facilities on campus, with reassignment of the caretaker staff to those facilities. While renovation is taking place, Core services are continuing uninterrupted at those alternate locations. This description of the Rodent Models Core includes an explanation of how this Core will operate when the animals return in 2007, with newly trained staff who will operate this exceptional and fully modernized facility serving the diverse scientific needs of MRDDRC investigators using rodent models. In the description below, the present tense is used to portray resources and services that continue uninterrupted in temporary locations during the renovation, past tense is used to refer to improvements made prior to the renovation, and future tense is used to refer to new Core services that will be provided after the renovation is completed in 2007. Therefore, the description of the Rodent Models Core reflects the strengths of past accomplishments as well as the promise of future achievements.

介绍 啮齿类动物模型核心为转基因动物的产生和表征提供技术支持， 敲除小鼠品系，获得昂贵的小鼠和大鼠行为设备， 在几个研究者中，以及在MRDD小鼠和大鼠模型的行为表型方面的专业知识 以及CNS的相关病症。此外，核心负责照顾，喂养和记录保存 与MRDDRC项目使用小鼠和大鼠以及维持特定啮齿类动物有关 发育模型、发育障碍和神经退行性疾病。这个核心已经 在本项目期间重新命名，反映了其重点的突出和大量新的专门知识 在过去五年中增加的服务，以应对不断增长和变化的 该委员会的目的是满足MRDDRC调查人员的需求，并为MRDDRC不断发展的科学议程做出贡献。 分配给这一核心的空间正在进行重大翻修，截至2005年1月， 所有动物临时搬迁到校园内的其他设施，与管理人员重新分配， 这些设施。在进行翻修期间，核心服务将不间断地继续在这些备用的 地点啮齿动物模型核心的描述包括对该核心如何操作的解释 当动物在2007年返回，与新培训的工作人员谁将操作这个特殊的和完全现代化的 使用啮齿动物模型，满足MRDDRC研究人员的各种科学需求。在描述中 下文中，现在时用于描述在临时期间不间断地继续提供的资源和服务。 在翻修期间，过去时态用于指翻修前所做的改进， 未来时态用于指在翻修完成后将提供的新核心服务， 2007.因此，啮齿动物模型核心的描述反映了过去成就的优势， 以及对未来成就的承诺。