Tracing the recent origins of a gene network regulating a novel morphological str

追踪调节新形态结构的基因网络的最新起源

• 批准号: 9043111
• 负责人: Mark J Rebeiz
• 金额: $ 31.39万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-05 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9043111
• 关键词: Animal Model; Animals; Automobile Driving; Cells; Characteristics; Complex; DNA Binding; Development; Disease; Drosophila genus; Drosophila melanogaster; Embryo; Enhancers; Event; Evolution; Gene Activation; Genes; Genetic; Genetic Programming; Genetic Variation; Genital system; Goals; Health; Heart; Human; Individual; Light; Lobe; Location; Male Genital Organs; Maps; Molecular; Molecular Genetics; Morphology; Organ; Output; Partner in relationship; Pattern; Phenotype; Predisposition; Process; Program Development; Recording of previous events; Recruitment Activity; Regulator Genes; Regulatory Element; Research; Signal Pathway; Signaling Molecule; Signaling Protein; Staging; Stretching; Structure; System; Techniques; Tissues; Variant; Work; appendage; embryo tissue; insight; novel; operation; programs; research study; tool; transcription factor; transcription factor USF

DESCRIPTION (provided by applicant): The goal of this research is to uncover the stepwise process by which new morphological structures and the networks that control their development evolve. Each and every morphological structure evolved at some point in the past, and our understanding of the origins of the developmental networks that spatially orchestrate development is still a mystery. It is becoming increasingly appreciated that our understanding of these networks at the molecular level will lie at the heart of connecting genetic variation to differences in phenotype, including the predisposition to disease. By characterizing a recently evolved morphological novelty of Drosophila melanogaster, this project will provide a unique perspective on how networks arise and are altered to generate differences in three dimensional forms.

描述（由申请人提供）：本研究的目标是揭示新的形态结构和控制其发育的网络进化的逐步过程。每一种形态结构都在过去的某个时刻进化，我们对空间协调发育的发育网络的起源的理解仍然是一个谜。人们越来越认识到，我们在分子水平上对这些网络的理解将成为将遗传变异与表型差异（包括疾病易感性）联系起来的核心。通过描述最近进化的果蝇形态新奇，该项目将提供一个独特的视角，了解网络如何产生和改变，以产生三维形式的差异。