New Methods for Nitrogen and Oxygen Heterocycle Synthesis

在此输入文本，它是您的应用程序的新摘要信息。此部分必须为no 超过30行的文本。 合成饱和氧、氮杂环的新反应 基于铜催化的对易得的烯烃的加成反应 发展起来的。手性铜络合物在立体控制CSP3-O和CSP3-O中的应用 Csp3-N键的形成正在探索中。基于我们在这方面的机械性工作 我们发现，极性反应和自由基反应的机理都是 涉及，并明智地选择底物和反应条件可以使 其他具有挑战性的络合物的简明和对映选择性的合成 来自简单的烯醇和烯胺底物的分子。在这个项目中，一个 对映选择性烯烃碳醚化反应范围扩大到有用氧 杂环化合物，如邻苯二甲酸，已显示活性的化合物，如1 受体配体(与中枢神经系统障碍治疗相关)。第一个高度 未活化烯烃的对映选择性氢烷氧基化合成 手性氧杂环化合物正在开发中。种类繁多的小说集 手性螺环化合物可以从1，1-二取代的烯烃中得到 一套铜催化的分子内烯二官能化反应。在……里面 在此背景下，新的铜催化的对映选择性烯烃二加氧和 将探索羟胺反应。潜在的强氧烯烃 氧化去功能化也在探索中。铜催化 乙烯芳烃和烷基自由基间的分子间偶联，原位形成， 正在探索合成氧和氮杂环。最后， 一种难以捉摸的与苯酚的催化对映选择性曼尼希反应正在进行 被追捕。生物活性饱和氧的简明对映体选择性合成 和氮杂环小分子将作为演示 这些反应的生物医学相关性。

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. New reactions for the synthesis of saturated oxygen and nitrogen heterocycles based on copper-catalyzed additions to readily available alkenes are being developed. The use of chiral copper complexes for stereocontrolled Csp3-O and Csp3-N bond formation is being explored. Based on our mechanistic work in this area, we have found that both polar and radical reaction mechanisms are involved, and judicious selection of substrate and reaction conditions can enable the concise and enantioselective synthesis of otherwise challenging complex molecules from simple alkenol and alkenylamine substrates. In this project, an enantioselective alkene carboetherification scope is expanded to useful oxygen heterocycles such as phthalans, compounds that have shown activity as 1 receptor ligands (relevant to CNS disorder therapy). The first highly enantioselective hydroalkoxylation of unactivated alkenes for the synthesis of chiral oxygen heterocycles is being developed. A diverse collection of novel chiral spirocyclic compounds is accessible from 1,1-disubstituted alkenes using a suite of copper-catalyzed intramolecular alkene difunctionalization reactions. In this context new copper-catalyzed enantioselective alkene dioxygenation and oxyamination reactions will be explored. Potentially powerful aerobic alkene oxidative difunctionalizations are also being explored. Copper-catalyzed intermolecular couplings between vinylarenes and alkyl radicals, formed in situ, are being explored for the synthesis of oxygen and nitrogen heterocycles. Lastly, an elusive catalytic enantioselective Mannich reaction with phenols is being pursued. The concise, enantioselective synthesis of bioactive saturated oxygen and nitrogen heterocyclic small molecules will be performed as a demonstration of the biomedical relevance of these reactions.