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Highly active iron precatalyst for hydrosilylation of ketones and aldehydes using industrially viable silanes - Phase I

使用工业上可行的硅烷进行酮和醛氢化硅烷化的高活性铁预催化剂 - 第一阶段

基本信息

批准号：
566839-2021
负责人：
Song, Datong
金额：
$ 9.11万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Idea to Innovation
财政年份：
2021
资助国家：
加拿大
起止时间：
2021-01-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=728724
关键词：
Highly active iron precatalyst hydrosilylation

项目摘要

Catalysts can accelerate chemical reactions and/or bias the formation of certain products over the others. Such a technology enables many chemical transformations that have impacted numerous aspects of our society. For example, the preparations of many pharmaceuticals, agrochemicals, and petrochemical products rely on the use of catalysts at various stages of the production processes. The reduction of ketones and aldehydes into the corresponding alcohols is a useful chemical transformation in many chemical syntheses. This transformation is commonly done with expensive and/or hazardous reducing reagents in industry. As an alternative, the catalytic hydrosilylation can be used to reduce ketones and aldehydes into alcohols, especially when the silane used in this process is non-hazardous and inexpensive under mild conditions. The requested funding is to further develop the catalysts invented by our group toward catalytic hydrosilyation of ketones and aldehydes using the non-hazardous and least expensive silane at ambient temperature. The goal of this research is to develop a synthetic protocol of the novel catalysts for large scale production at lower cost for industrial applications. Our catalysts use iron instead of the expensive and toxic noble metals and have extremely high catalytic activity. The proposed work aims to bridge the gap between the research lab discovery and the large-scale manufacture processes in industry.

催化剂可以加速化学反应和/或使某些产物的形成偏向于其他产物。这种技术使许多化学转化成为可能，影响了我们社会的许多方面。例如，许多药品、农用化学品和石油化工产品的制备在生产过程的各个阶段都依赖于催化剂的使用。酮和醛还原成相应的醇在许多化学合成中是一种有用的化学转化。在工业中，这种转化通常是用昂贵和/或危险的还原试剂完成的。作为一种替代方法，催化硅氢化反应可用于将酮类和醛类还原为醇类，特别是在该过程中使用的硅烷无害且在温和条件下价格低廉的情况下。申请资金用于进一步开发本课题组发明的催化剂，使用无害且最便宜的硅烷在室温下催化酮类和醛类的氢硅化反应。本研究的目标是开发一种新型催化剂的合成方案，用于大规模生产和低成本的工业应用。我们的催化剂使用铁代替昂贵和有毒的贵金属，具有极高的催化活性。提出的工作旨在弥合实验室研究发现与工业大规模制造过程之间的差距。