Highly active iron precatalyst for hydrosilylation of ketones and aldehydes using industrially viable silanes - Phase I

催化剂可以加速化学反应和/或使某些产物的形成偏向于其他产物。这种技术可以实现许多化学变化，这些变化已经影响了我们社会的许多方面。例如，许多药品、农用化学品和石化产品的制备在生产过程的不同阶段都依赖于催化剂的使用。在许多化学合成中，酮和醛还原成相应的醇是一种有用的化学转化。在工业中，这种转化通常使用昂贵的和/或危险的还原试剂。作为替代，催化硅氢加成反应可用于将酮和醛还原为醇，特别是当该过程中使用的硅烷在温和的条件下是无害和廉价的时。申请的资金是为了进一步开发我们团队发明的催化剂，用于在常温下使用无害和最便宜的硅烷催化酮和醛的硅氢化反应。本研究的目标是开发一种新型催化剂的合成方案，以便以较低的成本大规模生产并应用于工业应用。我们的催化剂使用铁而不是昂贵和有毒的贵金属，具有极高的催化活性。这项拟议的工作旨在弥合研究实验室发现和工业大规模制造过程之间的差距。

Catalysts can accelerate chemical reactions and/or bias the formation of certain products over the others. Such a technology enables many chemical transformations that have impacted numerous aspects of our society. For example, the preparations of many pharmaceuticals, agrochemicals, and petrochemical products rely on the use of catalysts at various stages of the production processes. The reduction of ketones and aldehydes into the corresponding alcohols is a useful chemical transformation in many chemical syntheses. This transformation is commonly done with expensive and/or hazardous reducing reagents in industry. As an alternative, the catalytic hydrosilylation can be used to reduce ketones and aldehydes into alcohols, especially when the silane used in this process is non-hazardous and inexpensive under mild conditions. The requested funding is to further develop the catalysts invented by our group toward catalytic hydrosilyation of ketones and aldehydes using the non-hazardous and least expensive silane at ambient temperature. The goal of this research is to develop a synthetic protocol of the novel catalysts for large scale production at lower cost for industrial applications. Our catalysts use iron instead of the expensive and toxic noble metals and have extremely high catalytic activity. The proposed work aims to bridge the gap between the research lab discovery and the large-scale manufacture processes in industry.