DEVELOPMENT OF MEDICAL COUNTERMEASURES TO MITIGATE AND/OR TREAT RADIATION-INDUCED LUNG INJURY AFTER A RADIOLOGICAL/NUCLEAR INCIDENT

制定医疗对策以减轻和/或治疗放射/核事件后辐射引起的肺损伤

• 批准号: 9274030
• 负责人: JIM HARRIS
• 金额: $ 210.19万
• 依托单位: LIGNAMED, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274030
• 关键词: Animal Model; Animals; Chest; Clinical; Contracts; Development; Drug Kinetics; Exposure to; Goals; Hour; Inflammatory; Injury; Ionizing radiation; Lung; Medical; Morbidity - disease rate; Nuclear; Pharmacodynamics; Pre-Clinical Model; Preclinical Testing; Process; Property; Radiation; Research Support; Structure of parenchyma of lung; Therapeutic; Tissues; in vivo; lung injury

This contract will support research to accelerate the development of safe and effective medical products to mitigate and/or treat pulmonary injury arising from exposure to ionizing radiation from a radiological or nuclear incident, thereby leading to a reduction in lung-associated morbidities that can impact survival. Currently, there are no approved therapeutic products in the Strategic National Stockpile (SNS) to be used specifically for radiation-induced pulmonary injury.

该合同将支持加速开发安全有效的医疗产品的研究，以减轻和/或治疗因辐射或核事故而暴露于电离辐射所引起的肺损伤，从而减少可能影响生存的与肺相关的发病率。目前，国家战略储备(SNS)中还没有批准的专门用于放射性肺损伤的治疗产品。