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Comprhensive Center of Excellence in Health Disparities

健康差异综合卓越中心

基本信息

批准号：
9013495
负责人：
JOHN H. HOLMES
金额：
$ 131.72万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-27 至 2018-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9013495
关键词：
Address Affect African African American American Area Behavioral Biological Biological Markers Communities Community Outreach Consultations Development Development Plans Diagnosis Discipline Ensure Environment Environmental Health Environmental Risk Factor European Evaluation Health Services Accessibility Healthcare Improve Access Individual Interdisciplinary Study Intervention Knowledge Malignant neoplasm of prostate Measures Mission Neighborhoods Obesity Outcome Patterns of Care Philadelphia Populations at Risk Postdoctoral Fellow Research Research Personnel Research Project Grants Resource Sharing Risk Risk Factors Role Training Translational Research Variant cancer health disparity cancer therapy career development contextual factors data management data modeling disparity reduction evidence base experience health disparity interdisciplinary collaboration men model building multilevel analysis next generation pre-doctoral predictive modeling programs racial difference response social success summer program

项目摘要

This Center of Excellence (COE) is being submitted to address significant gaps in our knowledge about disparities prostate cancer (PCa) outcomes, and to develop interventions that can be applied to reduce these disparities between African (AA) and European (EA) Americans in Philadelphia. The mission of the proposed center is to (1) undertake research that will identify biological, behavioral, social, environmental, geospatial, physical environmental, and health care factors that influence PCa outcomes, and (2) integrate, evaluate, and disseminate this information to at-risk populations in Philadelphia communities. These factors include both individual and area-level contextual (e.g., neighborhood) variables. We anticipate that the principles of this approach will ultimately be implementable in other communities to reduce PCa disparities. This COE builds on our existing multidisciplinary research to specifically understand role of biomarkers, patterns of care, geospatial environment, and obesity after the diagnosis of PCa. This research requires transdisciplinary collaboration across multiple disciplines represented by the investigators participating in this COE. The proposed COE intends to catalyze needed improvements in the identification of men at greatest risk of unfavorable PCa outcomes to improve access to appropriate PCa treatment with the following Specific Aims: Aim 1: To conduct three highly interrelated transdisciplinary, translational research projects aimed at addressing prostate cancer disparities: a) Project 1: Evaluate the role of obesity in determining unfavorable prostate cancer outcomes (C. Zeigler-Johnson, PI); Project 2: Develop predictive models for understanding biomarkers, area-level contextual factors, and individual risk factors in predicting prostate cancer outcomes (T. Rebbeck, PI); Project 3: Determine whether variation in experienced and potential health care access and quality contributes to racial differences in treatment among men with localized prostate cancer (K. Armstrong, PI). Aim 2. To create specialized shared resource cores to serve the needs of these projects and the Center, including an Administrative Core (T. Rebbeck, Director); a research core (J. Holmes and C. Branas, co-Directors); and a community core (K. Glanz, Director). Aim 3: To develop transdisciplinary training at a variety of levels to train the next generation of health disparities researchers. Through this research, community outreach, and training, we will develop a program that can identify those groups at greatest risk for an unfavorable prostate cancer outcome, and develop approaches that can be used to minimize poor outcomes and the resulting disparities that unduly burden AA men.

该卓越中心（COE）正在提交，以解决我们在前列腺癌（PCa）结果差异方面的重大知识差距，并开发可用于减少费城非洲（AA）和欧洲（EA）美国人之间这些差异的干预措施。该中心的任务是(1)开展研究，确定影响前列腺癌结果的生物、行为、社会、环境、地理空间、物理环境和卫生保健因素；(2)整合、评估并向费城社区的高危人群传播这些信息。这些因素包括个人和区域层面的环境变量（例如，社区）。我们预计这种方法的原则最终将在其他社区实施，以减少PCa的差异。