Rapid PCR to Guide Antibiotic Therapy at the Time of Prostate Biopsy
Rapid PCR to Guide Antibiotic Therapy at the Time of Prostate Biopsy
批准号:
9168209
负责人:
Michael Andre Liss
金额:
$10.0万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-07-01 至 2018-12-31
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
A prostate biopsy is the most common procedure to evaluate an elevated prostate specific antigen (PSA) or
abnormal prostate exam during prostate cancer screening. The biopsy is typically performed with a rectal
ultrasound in order to guide needle biopsies into designated areas of the prostate. The office-based procedure
is relatively safe and is one of the most common urologic procedures performed in industrialized countries.
However, the most common class of antibiotics used to protect from infection (fluoroquinolone) has become
less effective due to resistance, despite it being the standard of care. A particular strain of bacteria named E.
coli ST131 causes the majority of infections due to it nearly inherent resistance to fluoroquinolones. In this
study, we randomize men to antibiotic augmentation by physician’s discretion (in addition to a fluoroquinolone
if they chose) versus a rapid test to identify the ST131 E. coli using polymerase chain reaction (PCR) at the
time of biopsy. If identified, we would advise the use of an additional antibiotic based on previous studies that
have identified antibiotics that typically are less resistant for that particular type of bacteria. We feel this would
reduce the current strategy of either augmenting all patients with more broad-spectrum antibiotics or using ill-
defined risk based strategy. The more targeted use of antibiotics could help preserve broad-spectrum
antibiotics and reduce future antibiotic resistance. A similar strategy has been described using rectal culture
prior to prostate biopsy; however, this technique has not been popularized in part due to logistical issues and
physician-patient inconvenience. We project that a rapid point of care test may be more easily implemented
across various practices and encourage more targeted use of antibiotics, while also reducing infections of the
prostate biopsy. Secondary aims of the study are to investigate the clinic workflow and perceptions of clinicians
and patients regarding the new technology. Previous attempts to guide prophylaxis have failed due to
implementation; therefore, our study will allow us to gain insight into how best to address antibiotic choices that
will have the best chance of success urologic practice.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Validation, Calibration, and Translation of Restriction Spectrum Imaging Signal Maps to enhance MRI diagnostic capabilities in Prostate Cancer
-
批准号:10639737
-
项目类别:
-
资助金额:$61.6万
-
财政年份:2023
-
负责人:Michael Andre Liss
-
依托单位:
Mays Cancer Center at UT Health SA
-
批准号:10460446
-
项目类别:
-
资助金额:$29.3万
-
财政年份:1997
-
负责人:Michael Andre Liss
-
依托单位:
国内基金
海外基金
登录
查看更多内容
基于荧光定量PCR准确高效检测食品发酵用曲种中黄曲霉菌污染情况及预警分析研究
-
批准号:2026JJ80836
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:周培华
-
依托单位:
超声生境分析无创预测儿童肝母细胞瘤新辅助化疗pCR及肿瘤微环境
-
批准号:2026JJ82036
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:彭颖慧
-
依托单位:
一种低VOC释放的车用PCR-PP复合材料研发
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:赵治书
-
依托单位:
MRI深度组学联合液体活检技术构建乳腺癌新辅助化疗后pCR状态精准量化预测体系
-
批准号:MS25H180029
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:蒋猛
-
依托单位:
常见染色体非整倍体检测试剂盒(荧光PCR-毛细管电泳法)应用示范项目
-
批准号:25SF1906100
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:王剑
-
依托单位:
金黄色葡萄球菌新型肠毒素多重荧光定量PCR检测试剂盒的研发及初步应用
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:陈琦
-
依托单位:
基于实时荧光定量PCR技术的深加工食品中福寿螺属检测方法的开发与应用研究
-
批准号:2025JJ80253
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:蒋伟
-
依托单位:
数字PCR技术在慢性阻塞性肺病伴侵袭性肺曲霉病的早期诊断价值研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:吴小脉
-
依托单位:
微卫星不稳定性(MSI)检测试剂盒(基于8个MSI位点、荧光PCR-毛细管电泳法)在结直肠癌真实世界中的应用评价
-
批准号:25SF1906300
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:周晓燕
-
依托单位:
构建基于血炎症标志物和咽部PCR的儿童肺炎致病菌判别模型
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:方潇倩
-
依托单位: