Nuclear Magnetic Resonance Shared Resource (NMR-SR)

核磁共振共享资源 (NMR-SR)

• 批准号: 9149428
• 负责人: CAROL B. POST
• 金额: $ 25.09万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149428
• 关键词: Area; Back; Binding; Binding Sites; Biochemistry; Biological; Biological Availability; Biology; Biomedical Engineering; Cancer Center Support Grant; Charge; Chemical Structure; Chemicals; Chemistry; Complex; Cyclic Peptides; Development; Diffusion; Doctor of Philosophy; Drug Delivery Systems; Electronics; Faculty; Funding; Human Resources; Individual; Information Technology; Knowledge; Laboratories; Lead; Ligands; Malignant Neoplasms; Measures; Molecular; NCI Center for Cancer Research; NMR Spectroscopy; Natural Products; Nuclear Magnetic Resonance; Organic Chemistry; Pathway interactions; Peer Review; Pharmaceutical Chemistry; Pharmaceutical Preparations; Property; Protein Dynamics; Proteins; Qualifying; Relaxation; Research; Research Personnel; Research Support; Reservations; Resource Sharing; Route; Sampling; Scheme; Services; Signal Pathway; Signal Transduction; Signaling Protein; Structural Biologist; Structure; System; Techniques; Tertiary Protein Structure; Testing; Time; Titrations; Toxic effect; Training; Walking; Work; base; cost effective; design; experience; high throughput screening; improved; inhibitor/antagonist; instrument; instrumentation; knowledge of results; meetings; member; metabolomics; novel; programs; protein complex; protein protein interaction; repaired; research study; structural biology; therapeutic target; three dimensional structure; two-dimensional

Nuclear Magnetic Resonance Shared Resource: Project Summary Chemistry Shared Resource Group In 2013, the broad range of services and collaborative work provided by the Nuclear Magnetic Resonance Shared Resource (NMR-SR) supported the research of 24 Purdue Center for Cancer Research (PCCR) members' laboratories, representing all four Research Programs. The value of the NMR-SR's services to the PCCR membership is critical because these instruments provide wide-ranging NMR capabilities which effectively serve the needs of PCCR's multi-disciplinary faculty. In the absence of the NMR-SR and its experienced staff, these investigators would not have rapid access to spectrometers that support both routine use and complex problems. The demand for NMR must be met locally as it is generally impractical for NMR spectroscopy to be done through an outside service. The synthetic chemist requires access to an NMR spectrometer on a daily basis and immediate knowledge of the results. It is also important that the structural biologist have routine access to characterize protein samples, execute titrations, and conduct the large number of experiments required for structure determination. The NMR-SR staff oversees ten NMR spectrometers ranging in field strength from 300 MHz to 800 MHz. All spectrometers are available 24/7 on a charge-back basis to individual researchers in the capacity of either `walk-on' usage as required by synthetic chemists, or long-term reservations as needed for biological NMR spectroscopy. The NMR-SR spectrometers are able to perform the entire gamut of modern NMR techniques needed by PCCR investigators in areas of chemistry and medicinal chemistry, biochemistry, biology, and biological/biomedical engineering. The available instrumentation and expertise provide convenient, reliable and cost-effective service to multi-disciplinary research in areas as diverse as protein and structural biology, organic chemistry, and metabolomics. The NMR-SR has qualified personnel from Ph.D.-level scientific knowledge of NMR spectroscopy to service, repair of magnets, electronics and information technology (IT). In addition, Purdue's NMR-SR staff excels in training new users and provides the expertise in the NMR-SR for supporting this necessary collaborative research. Overall, through its PCCR and institutionally supported facilities and staff, the NMR-SR provides a convenient, reliable and cost-effective service for PCCR members.

核磁共振共享资源： 项目摘要 化学共享资源组 在2013年，核磁共振所提供的广泛服务和协作工作 共享资源（NMR-SR）支持24普渡癌症研究中心（PCCR）的研究 成员的实验室，代表所有四个研究计划。NMR-SR的服务价值 PCCR成员资格至关重要，因为这些仪器提供广泛的NMR能力， 有效地满足PCCR多学科教师的需求。在没有《国家报告》及其 经验丰富的工作人员，这些研究人员将无法快速获得光谱仪，支持常规的 使用和复杂的问题。核磁共振的需求必须在当地得到满足，因为核磁共振通常是不切实际的 通过外部服务进行光谱分析。合成化学家需要核磁共振仪 每天使用光谱仪，并立即了解结果。同样重要的是， 生物学家有常规的访问来表征蛋白质样品，执行滴定，并进行大量 结构测定所需的实验。 NMR-SR工作人员负责监督10台场强从300 MHz到800 MHz的NMR光谱仪。 所有光谱仪都可以24/7收费的基础上提供给个人研究人员的能力， 根据合成化学家的要求，可"随叫随到"使用，或根据生物NMR的需要，可长期保留 谱NMR-SR光谱仪能够执行现代NMR技术的全部功能 PCCR研究人员在化学和药物化学、生物化学、生物学和 生物/生物医学工程可用的仪器和专业知识提供方便，可靠 为蛋白质和结构生物学等领域的多学科研究提供具有成本效益的服务， 有机化学和代谢组学 NMR-SR拥有从博士到博士的合格人员。水平的NMR光谱学的科学知识， 服务、磁铁维修、电子和信息技术（IT）。此外，普渡大学的NMR-SR工作人员 擅长培训新用户，并提供NMR-SR方面的专业知识，以支持这一必要的 合作研究。总的来说，通过其PCCR和机构支持的设施和工作人员， 为PCCR会员提供方便、可靠及具成本效益的服务。