Nuclear Magnetic Resonance Shared Resource (NMR-SR)

核磁共振共享资源： 项目摘要 化学共享资源群 2013年，核磁共振提供的广泛服务和协作工作 共享资源(核磁共振-SR)支持24个普渡癌症研究中心(PCCR) 成员实验室，代表所有四个研究项目。核磁共振-SR服务的价值 PCCR成员资格至关重要，因为这些仪器提供了广泛的核磁共振功能， 有效地满足PCCR多学科教员的需求。在没有核磁共振波谱和它的 经验丰富的工作人员，这些调查人员不会快速访问支持这两个例行程序的光谱仪 使用和复杂的问题。核磁共振的需求必须在当地满足，因为核磁共振通常是不切实际的 光谱学是通过外部服务完成的。合成化学家需要接触到核磁共振 每天对光谱仪进行测量，并即时了解结果。同样重要的是，结构性的 生物学家有常规的途径来鉴定蛋白质样本，执行滴定，并进行大量的 进行结构测定所需的实验。 核磁共振-SR工作人员负责监管10台核磁共振光谱仪，其场强从300 MHz到800 MHz不等。 所有光谱仪都可以24/7全天候免费提供给个人研究人员， 根据合成化学家的要求使用，或根据生物核磁共振所需的长期保留 光谱学。核磁共振-核磁共振波谱仪能够执行现代核磁共振技术的全部范围 PCCR研究人员在化学和药物化学、生物化学、生物学和 生物/生物医学工程。可用的仪器和专业知识为您提供方便、可靠的 为蛋白质和结构生物学等不同领域的多学科研究提供经济高效的服务， 有机化学和代谢组学。 核磁共振-SR拥有具有博士水平的核磁共振波谱科学知识的合格人员，以 磁铁、电子和信息技术(IT)的服务、维修。此外，普渡大学的核磁共振-SR工作人员 擅长培训新用户，并提供核磁共振-SR方面的专业知识，以支持必要的 合作研究。总体而言，通过其PCCR和机构支持的设施和工作人员，核磁共振-SR 为PCCR会员提供方便、可靠和经济高效的服务。

Nuclear Magnetic Resonance Shared Resource: Project Summary Chemistry Shared Resource Group In 2013, the broad range of services and collaborative work provided by the Nuclear Magnetic Resonance Shared Resource (NMR-SR) supported the research of 24 Purdue Center for Cancer Research (PCCR) members' laboratories, representing all four Research Programs. The value of the NMR-SR's services to the PCCR membership is critical because these instruments provide wide-ranging NMR capabilities which effectively serve the needs of PCCR's multi-disciplinary faculty. In the absence of the NMR-SR and its experienced staff, these investigators would not have rapid access to spectrometers that support both routine use and complex problems. The demand for NMR must be met locally as it is generally impractical for NMR spectroscopy to be done through an outside service. The synthetic chemist requires access to an NMR spectrometer on a daily basis and immediate knowledge of the results. It is also important that the structural biologist have routine access to characterize protein samples, execute titrations, and conduct the large number of experiments required for structure determination. The NMR-SR staff oversees ten NMR spectrometers ranging in field strength from 300 MHz to 800 MHz. All spectrometers are available 24/7 on a charge-back basis to individual researchers in the capacity of either `walk-on' usage as required by synthetic chemists, or long-term reservations as needed for biological NMR spectroscopy. The NMR-SR spectrometers are able to perform the entire gamut of modern NMR techniques needed by PCCR investigators in areas of chemistry and medicinal chemistry, biochemistry, biology, and biological/biomedical engineering. The available instrumentation and expertise provide convenient, reliable and cost-effective service to multi-disciplinary research in areas as diverse as protein and structural biology, organic chemistry, and metabolomics. The NMR-SR has qualified personnel from Ph.D.-level scientific knowledge of NMR spectroscopy to service, repair of magnets, electronics and information technology (IT). In addition, Purdue's NMR-SR staff excels in training new users and provides the expertise in the NMR-SR for supporting this necessary collaborative research. Overall, through its PCCR and institutionally supported facilities and staff, the NMR-SR provides a convenient, reliable and cost-effective service for PCCR members.