Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndrome

基于分子印迹聚合物的传感器阵列用于诊断干燥综合征

基本信息

  • 批准号:
    9245475
  • 负责人:
  • 金额:
    $ 34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-23 至 2020-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Diagnosing Sjögren's syndrome (SS) in the early stages of the disease can help mitigate damage from systemic manifestations that occur later in the disease. Current tests for establishing an SS diagnosis include salivary gland biopsy to look for lymphocytic inflammation and using radioactive labeling to test salivary gland function. While these tests are effective in the diagnosis of SS, the multiplex biosensor developed in this proposal will provide a low-cost method for detecting molecular evidence of both salivary/lacrimal gland hypofunction and lymphocytic inflammation without the need for invasive testing. Molecularly imprinted polymers (MIPs) are synthetic materials capable of semi-selective molecular recognition and are lower cost and more environmentally robust than antibodies. In this proposal, MIPs will be synthesized on the surface of nanomaterials with unique optical properties for use in sensing applications. Specifically, collections of MIP- coated gold nanomaterials will be employed in “differential sensing,” routines to monitor biomarkers of lymphocytic inflammation and gland hypofunction simultaneously, providing a more comprehensive view of protein mixtures. Instead of identifying a single biomarker, the developed sensor arrays will generate a pattern based on numerous biomarkers, providing a more robust diagnostic tool for biochemical changes. The overall hypothesis of this proposal is that imprinted nanomaterials in optical sensor arrays may detect biomarkers that could be used to establish an SS diagnosis in symptomatic patients. The specific goals of this proposal are (Aim 1) to rationally choose strong-bonding monomers (non-covalent or reversible-covalent) to improve MIP affinity, (Aim 2) to synthesize MIPs on the surface of gold nanomateirals to generate receptors with built-in signal transduction and (Aim 3) to test these imprinted nanomaterials in sensor arrays to detect SS biomarkers.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Eric V. Anslyn其他文献

Ein Chemosensor zur Bestimmung von Citrat in Getränken
格特兰肯 (Getränken) 的 Citrat 最佳化学传感器
  • DOI:
  • 发表时间:
    1998
  • 期刊:
  • 影响因子:
    0
  • 作者:
    A. Metzger;Eric V. Anslyn
  • 通讯作者:
    Eric V. Anslyn
Dynamic Covalent Chemistry within Biphenyl Scaffolds: Reversible Covalent Bonding, Control of Selectivity, and Chirality Sensing with a Single System
  • DOI:
    doi.org/10.1002/anie.201711602
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
  • 作者:
    Cailing Ni;Daijun Zha;Hebo Ye;Yu Hai;Yuntao Zhou;Eric V. Anslyn;Lei You
  • 通讯作者:
    Lei You
Scaling-up molecular logic to meso-systems via self-assembly
通过自组装将分子逻辑扩展到介观系统
  • DOI:
    10.1038/s41467-025-58379-0
  • 发表时间:
    2025-03-28
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Ze-Qing Chen;Brian Daly;Chao-Yi Yao;Hannah S. N. Crory;Yikai Xu;Ziwei Ye;H. Q. Nimal Gunaratne;Ayumi Kimura;Seiichi Uchiyama;Steven E. J. Bell;Eric V. Anslyn;A. Prasanna de Silva
  • 通讯作者:
    A. Prasanna de Silva
Erkennung von Anionen in einem bicyclischen Cyclophan durch Wasserstoffbrückenbindungen zu deren π‐System ‐ unerwartete Selektivität für Nitrat
在 einem bicyclischen Cyclophan durch Wasserstoffbrückenbindungen zu deren π 系统 ‐ unerwartete Selektivität für Nitrat
  • DOI:
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    0
  • 作者:
    A. Bisson;Vincent M. Lynch;Mary‐Katherine C. Monahan;Eric V. Anslyn
  • 通讯作者:
    Eric V. Anslyn
DER MECHANISMUS DER RNA-SPALTUNG DURCH UMESTERUNG : EINE VEREINHEITLICHENDE ANALYSE DES AKTUELLEN DISKUSSIONSSTANDES
RNA-SPALTUNG DURCH UMESTERUNG 的机制:对当前讨论情况进行分析
  • DOI:
    10.1002/ange.19971090505
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Denise M. Perreault;Eric V. Anslyn
  • 通讯作者:
    Eric V. Anslyn

Eric V. Anslyn的其他文献

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{{ truncateString('Eric V. Anslyn', 18)}}的其他基金

Facilitating the Chemistry of Fluorosequencing
促进荧光测序的化学发展
  • 批准号:
    10623602
  • 财政年份:
    2023
  • 资助金额:
    $ 34万
  • 项目类别:
Deployable 3D-printed Cellular Communities for Characterizing Bacterial Social Cues and Chemical Warfare
可部署的 3D 打印细胞群落,用于表征细菌社交线索和化学战
  • 批准号:
    10005373
  • 财政年份:
    2019
  • 资助金额:
    $ 34万
  • 项目类别:
Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndrome
基于分子印迹聚合物的传感器阵列用于诊断干燥综合征
  • 批准号:
    9357588
  • 财政年份:
    2016
  • 资助金额:
    $ 34万
  • 项目类别:
2014 Spring GSSPC Symposium
2014年春季GSSPC研讨会
  • 批准号:
    8720407
  • 财政年份:
    2014
  • 资助金额:
    $ 34万
  • 项目类别:
Refining & Implementing Supramolecular Methods for HTS of EE & Concentration
精制
  • 批准号:
    7987195
  • 财政年份:
    2006
  • 资助金额:
    $ 34万
  • 项目类别:
Refining & Implementing Supramolecular Methods for HTS of EE & Concentration
精制
  • 批准号:
    8326184
  • 财政年份:
    2006
  • 资助金额:
    $ 34万
  • 项目类别:
Colorimetric Assays for Enantiomeric Excess
对映体过量的比色测定
  • 批准号:
    7390853
  • 财政年份:
    2006
  • 资助金额:
    $ 34万
  • 项目类别:
Refining & Implementing Supramolecular Methods for HTS of EE & Concentration
精制
  • 批准号:
    8142187
  • 财政年份:
    2006
  • 资助金额:
    $ 34万
  • 项目类别:
Colorimetric Assays for Enantiomeric Excess
对映体过量的比色测定
  • 批准号:
    7599254
  • 财政年份:
    2006
  • 资助金额:
    $ 34万
  • 项目类别:
Colorimetric Assays for Enantiomeric Excess
对映体过量的比色测定
  • 批准号:
    7216916
  • 财政年份:
    2006
  • 资助金额:
    $ 34万
  • 项目类别:

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