An MR-Compatible Small Animal SPECT Based on Artifical Compound Eye Cameras

该项目是为了开发第二代磁共振兼容SPECT系统(MRC-SPECT- Ii)。基于新型倒置复眼伽马相机的MRC-SPECT-II系统 设计将提供显著改进SPECT成像仪器的潜力，从几个 方面。首先，这种方法通过以下方式帮助解决SPECT检测中最具局限性的一个方面 在不牺牲其分辨率的情况下提供显著提高的灵敏度。建议的管理资源中心- SPECT-II系统可以提供前所未有的1.5%的灵敏度和重建的成像分辨率 直径0.5毫米、直径1.5厘米的视场(FOV)，1.2毫米空间分辨率时为9%(与 现代临床前SPECT仪器中发现的典型水平为0.1%-0.01%)。这大大增加了 在检测中，灵敏度可能会从根本上改变我们如何使用SPECT成像 通过提供大幅降低的检测下限和允许新的成像程序进行临床前研究 对于当前一代的SPECT仪器来说，这是不可行的。第二，冰上相机 设计允许MRC-SPECT-II系统的物理尺寸显著减小，而与 任何现有的SPECT系统都有类似的视野。这将允许MRC-SPECT-II系统(以及未来 基于类似ICE相机设计的MRC-SPECT系统)将集成到大多数现有的MR扫描仪中。 第三，ICE相机的设计还可以显著提高放大SPECT的灵敏度 用于大型动物和人类(例如大脑和心脏)成像应用的扫描仪。最后，提出了 MRC-SPECT-II系统允许同时进行SPECT和高场(9.4T)磁共振成像研究。在这个范围内 具体项目，将开发和改进MRC-SPECT-II系统，用于体内疗效和 治疗工程神经干细胞在恶性脑瘤中的命运，这可能有助于实现这一点 临床实践中很有希望的治疗方法。

This proposed project is for developing the second-generation MR-compatible SPECT system (MRC-SPECT- II). The proposed MRC-SPECT-II system, based on a novel inverted compound-eye (ICE) gamma camera design would offer the potential of dramatically improving SPECT imaging instrumentation from several aspects. First, this approach helps to tackle one of the most limiting aspects of SPECT instrumentation, by offering a dramatically improved sensitivity without sacrificing its resolution capability. The proposed MRC- SPECT-II system could offer an unprecedented sensitivity of 1.5% with a reconstructed imaging resolution of 0.5 mm across and 1.5 cm diameter field-of-view (FOV), and 9% at 1.2 mm spatial resolution (as compared to the typical levels of 0.1% - 0.01% found in modern pre-clinical SPECT instrumentations). This greatly increase in detection sensitivity could potentially provide a radical change in how we might employ SPECT imagining in pre-clinical research by offering a dramatically lowered detection limit and allowing for new imaging procedures that would not be feasible with the current generation of SPECT instrumentations. Second, the ICE-camera design allows the MRC-SPECT-II system to have a significantly reduced physical dimension, while compared to any existing SPECT systems with similar FOV. This would allow the MRC-SPECT-II system (and future MRC-SPECT systems based on similar ICE camera design) to be integrated in most of existing MR scanners. Third, the ICE camera design could also offer dramatically improved sensitivities for scaled-up SPECT scanners for large animals and for human (e.g. brain and heart) imaging applications. Finally, the proposed MRC-SPECT-II system allows for simultaneous SPECT and high-field (9.4T) MR imaging studies. Within this particular project, the MRC-SPECT-II system will be developed and refined for in vivo study of the efficacy and fate of therapeutically engineered neural stem cells in malignant brain tumors, which could help to bring this promising therapeutic approach into clinical practice.