An MR-Compatible Small Animal SPECT Based on Artifical Compound Eye Cameras
基于人工复眼相机的 MR 兼容小动物 SPECT
基本信息
- 批准号:9252072
- 负责人:
- 金额:$ 59.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-15 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAnimalsArtsAutoradiographyBiological ModelsBrainBrain NeoplasmsCaliberChairpersonChicagoCollimatorComputer softwareDetectionDevelopmentDimensionsEarly DiagnosisEngineeringEvaluationExcisionExploratory/Developmental Grant for Diagnostic Cancer ImagingFeasibility StudiesFluorescence MicroscopyFutureGamma CamerasGenerationsGoalsGrantHumanImageImaging TechniquesJournalsLegal patentLettersLifeMagnetic Resonance ImagingMalignant neoplasm of brainManuscriptsModelingMonitorMonte Carlo MethodMovementMusOperating SystemOperative Surgical ProceduresPaperPerformancePhysiologic pulseRF coilReportingResearchResearch DesignResearch Project GrantsResolutionSemiconductorsSeriesSliceSystemTechniquesTechnologyTherapeuticUnited States National Institutes of HealthWagesWorkbaseclinical practicecompound eyedesigndetectorheart imagingimage reconstructionimaging platformimaging systemimprovedin vivoin vivo imaginginstrumentationmouse modelnerve stem cellneurosurgerynovelpre-clinicalpre-clinical researchresponsescale upsingle photon emission computed tomographysymposiumtargeted treatmenttumor progression
项目摘要
This proposed project is for developing the second-generation MR-compatible SPECT system (MRC-SPECT-
II). The proposed MRC-SPECT-II system, based on a novel inverted compound-eye (ICE) gamma camera
design would offer the potential of dramatically improving SPECT imaging instrumentation from several
aspects. First, this approach helps to tackle one of the most limiting aspects of SPECT instrumentation, by
offering a dramatically improved sensitivity without sacrificing its resolution capability. The proposed MRC-
SPECT-II system could offer an unprecedented sensitivity of 1.5% with a reconstructed imaging resolution of
0.5 mm across and 1.5 cm diameter field-of-view (FOV), and 9% at 1.2 mm spatial resolution (as compared to
the typical levels of 0.1% - 0.01% found in modern pre-clinical SPECT instrumentations). This greatly increase
in detection sensitivity could potentially provide a radical change in how we might employ SPECT imagining in
pre-clinical research by offering a dramatically lowered detection limit and allowing for new imaging procedures
that would not be feasible with the current generation of SPECT instrumentations. Second, the ICE-camera
design allows the MRC-SPECT-II system to have a significantly reduced physical dimension, while compared
to any existing SPECT systems with similar FOV. This would allow the MRC-SPECT-II system (and future
MRC-SPECT systems based on similar ICE camera design) to be integrated in most of existing MR scanners.
Third, the ICE camera design could also offer dramatically improved sensitivities for scaled-up SPECT
scanners for large animals and for human (e.g. brain and heart) imaging applications. Finally, the proposed
MRC-SPECT-II system allows for simultaneous SPECT and high-field (9.4T) MR imaging studies. Within this
particular project, the MRC-SPECT-II system will be developed and refined for in vivo study of the efficacy and
fate of therapeutically engineered neural stem cells in malignant brain tumors, which could help to bring this
promising therapeutic approach into clinical practice.
该拟议项目旨在开发第二代 MR 兼容 SPECT 系统(MRC-SPECT-
二)。所提出的 MRC-SPECT-II 系统基于新型倒置复眼 (ICE) 伽马相机
设计将提供显着改进 SPECT 成像仪器的潜力
方面。首先,这种方法有助于解决 SPECT 仪器最限制的方面之一:
在不牺牲分辨率能力的情况下提供显着提高的灵敏度。拟议的 MRC-
SPECT-II 系统可提供前所未有的 1.5% 灵敏度,重建成像分辨率为
宽度为 0.5 毫米,视野 (FOV) 直径为 1.5 厘米,空间分辨率为 1.2 毫米时为 9%(与
现代临床前 SPECT 仪器中的典型水平为 0.1% - 0.01%)。这大大增加了
检测灵敏度的提高可能会彻底改变我们如何使用 SPECT 成像
通过提供显着降低的检测限并允许新的成像程序来进行临床前研究
这对于当前一代 SPECT 仪器来说是不可行的。二、ICE相机
设计使得 MRC-SPECT-II 系统的物理尺寸显着减小,而与
任何现有的具有类似 FOV 的 SPECT 系统。这将使 MRC-SPECT-II 系统(以及未来的
基于类似 ICE 相机设计的 MRC-SPECT 系统)将集成到大多数现有 MR 扫描仪中。
第三,ICE 相机设计还可以显着提高放大 SPECT 的灵敏度
用于大型动物和人体(例如大脑和心脏)成像应用的扫描仪。最后,提出的
MRC-SPECT-II 系统允许同时进行 SPECT 和高场 (9.4T) MR 成像研究。在此范围内
特定项目中,MRC-SPECT-II 系统将被开发和完善,用于体内研究功效和
治疗工程神经干细胞在恶性脑肿瘤中的命运,这可能有助于实现这一目标
有前景的治疗方法进入临床实践。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Chin-Tu Chen其他文献
Chin-Tu Chen的其他文献
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{{ truncateString('Chin-Tu Chen', 18)}}的其他基金
Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, and MR Imaging - Resubmission 01
通过集成 PET、EPR 和 MR 成像改进缺氧肿瘤区域的放射治疗 - 重新提交 01
- 批准号:
9897365 - 财政年份:2020
- 资助金额:
$ 59.39万 - 项目类别:
Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, and MR Imaging - Resubmission 01
通过集成 PET、EPR 和 MR 成像改进缺氧肿瘤区域的放射治疗 - 重新提交 01
- 批准号:
10544779 - 财政年份:2020
- 资助金额:
$ 59.39万 - 项目类别:
Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, and MR Imaging - Resubmission 01
通过集成 PET、EPR 和 MR 成像改进缺氧肿瘤区域的放射治疗 - 重新提交 01
- 批准号:
10314063 - 财政年份:2020
- 资助金额:
$ 59.39万 - 项目类别:
Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, and MR Imaging - Resubmission 01 - Revision - 1
通过集成 PET、EPR 和 MR 成像改进缺氧肿瘤区域的放射治疗 - 重新提交 01 - 修订版 - 1
- 批准号:
10289582 - 财政年份:2020
- 资助金额:
$ 59.39万 - 项目类别:
PET imaging of a4b2 nicotinic receptor upregulation and smoking cessation
a4b2 烟碱受体上调和戒烟的 PET 成像
- 批准号:
9919536 - 财政年份:2017
- 资助金额:
$ 59.39万 - 项目类别:
PET imaging of a4b2 nicotinic receptor upregulation and smoking cessation
a4b2 烟碱受体上调和戒烟的 PET 成像
- 批准号:
9403663 - 财政年份:2017
- 资助金额:
$ 59.39万 - 项目类别:
PET imaging of a4b2 nicotinic receptor upregulation and smoking cessation
a4b2 烟碱受体上调和戒烟的 PET 成像
- 批准号:
10152562 - 财政年份:2017
- 资助金额:
$ 59.39万 - 项目类别:
An MR-Compatible Small Animal SPECT Based on Artifical Compound Eye Cameras
基于人工复眼相机的 MR 兼容小动物 SPECT
- 批准号:
9752622 - 财政年份:2016
- 资助金额:
$ 59.39万 - 项目类别:
An MR-Compatible Small Animal SPECT Based on Artifical Compound Eye Cameras
基于人工复眼相机的 MR 兼容小动物 SPECT
- 批准号:
9353404 - 财政年份:2016
- 资助金额:
$ 59.39万 - 项目类别:
An Ultra High Resolution SPECT System Integrated with a High-Field MRI Scanner
与高场 MRI 扫描仪集成的超高分辨率 SPECT 系统
- 批准号:
8496038 - 财政年份:2011
- 资助金额:
$ 59.39万 - 项目类别:
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