Center for Studies of Host Response to Cancer Therapy

 描述（由申请人提供）：癌症治疗宿主反应研究中心的目标是（1）在阿肯色州医科大学（UAMS）内建立一个自我维持的多学科研究中心，研究癌症治疗诱导毒性的机制和预防策略，（2）帮助具有共同研究重点的初级研究人员成为独立的科学家。实现这些目标将创造一个充满活力的协同研究环境，以全面解决癌症治疗副作用的机制，并制定有效的策略来预防此类副作用。据我们所知，很少有中心关注癌症幸存者，也没有一个中心采取主动解决治疗相关毒性的范式转变方法。具体而言，该中心将为年轻的研究人员提供一个环境，使他们能够成为独立的科学家（目标1）;加强UAMS和癌症研究所的整体研究基础设施（目标2）;并确保宿主对癌症治疗反应研究中心能够自我维持（目标3）。最初的四个项目负责人是有前途的新的/早期阶段的研究人员，他们有自己的积极研究计划，并与其他项目负责人和/或导师建立了合作关系。所有人都有自己的研究实验室，都有自己的终身教职，而且都得到了各自部门慷慨的机构启动计划。机会将通过实施个性化的辅导和教师发展计划，并提供指导和支持，从行政和两个科学核心。强有力的机构支持加上供资机构对改善癌症幸存者生活质量的积极兴趣，确保了成功的可能性很高。为了取代那些从COBRE支持中获得独立和“毕业”的项目领导人，通过对招聘初级教师的机构支持，结合结构化的试点项目计划，确保了新项目领导人的“管道”。建立强大的中心核心和与现有机构核心的合作也将有助于建立中心宿主对癌症治疗的反应研究作为校园内的自我维持中心。中心的进展将由外部和内部咨询委员会以及核心监督委员会指导。内部咨询委员会由担任关键职位的个人组成，具有来自整个机构的广泛代表性，并在中心的成就中享有既得利益，这也将确保中心的初步成功 作为校园里一个独立单位的长期可行性。

 DESCRIPTION (provided by applicant): The objectives of the Center for Studies of Host Response to Cancer Therapy are to (1) form a self- sustaining multidisciplinary research center within the University of Arkansas for Medical Sciences (UAMS) that examines mechanisms of and prevention strategies for cancer-therapy-induced toxicity and (2) help junior investigators with a common research focus establish themselves as independent scientists. Achieving these goals will create a vibrant, synergistic research environment to comprehensively address the mechanisms of side effects of cancer therapy and to develop effective strategies to prevent such side effects. To our knowledge, few centers exist that focus on cancer survivors, and none take the paradigm-shifting approach of proactively addressing treatment-related toxicities. Specifically, this Center will provide an environment for young investigators to succeed as independent scientists (Aim 1); strengthen the overall research infrastructure at UAMS and the Cancer Institute (Aim 2); and ensure that the Center for Studies of Host Response to Cancer Therapy becomes self-sustaining (Aim 3). The four initial Project Leaders are promising new/early-stage investigators with their own active research programs and established collaborations with fellow Project Leaders and/or mentors. All are in the tenure track with their own research laboratories, and all have been provided generous institutional startup packages by their departments. Opportunities will be provided by implementing individualized mentoring and faculty development plans and by offering guidance and support from an administrative and two scientific cores. A high likelihood of success is ensured by strong institutional support combined with active interest from funding agencies in improving quality of life among cancer survivors. To replace Project Leaders who achieve independence and "graduate" from COBRE support, a "pipeline" of new Project Leaders is ensured through institutional support for recruitment of junior faculty, combined with a structured pilot project program. Building strong Center cores and collaborations with existing institutional cores will also contribute to establishing the Center for Studies of Host Response to Cancer Therapy as a self-sustaining center on campus. The Center's progress will be guided by External and Internal Advisory Committees and a Core Oversight Committee. The Internal Advisory Committee, comprised of individuals in key positions, with broad representation from across the institution and with a vested interest in the Center's achievements, will ensure the initial success of the Center as well as its long-term viability as an independent unit on campus.