Center for Studies of Host Response to Cancer Therapy

 描述(由申请人提供)：癌症治疗宿主反应研究中心的目标是(1)在阿肯色州医科大学(UAMS)内建立一个自给自足的多学科研究中心，研究癌症治疗诱导毒性的机制和预防策略，(2)帮助具有共同研究重点的初级研究人员确立自己的独立科学家地位。实现这些目标将创造一个充满活力的、协同的研究环境，以全面解决癌症治疗副作用的机制，并开发有效的战略来预防此类副作用。据我们所知，很少有关注癌症幸存者的中心，也没有一个采取改变范式的方法，主动解决与治疗相关的毒性问题。具体地说，该中心将为年轻研究人员提供作为独立科学家取得成功的环境(目标1)；加强UAMS和癌症研究所的整体研究基础设施(目标2)；并确保宿主对癌症治疗的反应研究中心能够自给自足(目标3)。最初的四名项目负责人承诺新的/早期调查人员拥有自己的积极研究计划，并与其他项目负责人和/或导师建立了合作关系。所有这些人都在拥有自己的研究实验室的终身教职轨道上，而且他们的部门都为他们提供了慷慨的机构启动方案。将通过实施个性化的指导和教师发展计划以及提供一个行政核心和两个科学核心的指导和支持来提供机会。成功的可能性很高，这是由强有力的机构支持和资助机构对提高癌症幸存者生活质量的积极兴趣确保的。为了取代那些实现独立并从科布雷支持下“毕业”的项目负责人，通过机构支持初级教员的招聘，结合结构化的试点项目计划，确保新的项目负责人的“管道”。建立强大的中心核心和与现有机构核心的合作也将有助于建立宿主对癌症治疗的反应研究中心，作为校园内一个自给自足的中心。中心的进展将由外部和内部咨询委员会以及一个核心监督委员会指导。内部咨询委员会由担任关键职位的个人组成，具有来自整个机构的广泛代表性，并对中心的成就有既得利益，也将确保中心取得初步成功 作为校园内的一个独立单位，它的长期生存能力。

 DESCRIPTION (provided by applicant): The objectives of the Center for Studies of Host Response to Cancer Therapy are to (1) form a self- sustaining multidisciplinary research center within the University of Arkansas for Medical Sciences (UAMS) that examines mechanisms of and prevention strategies for cancer-therapy-induced toxicity and (2) help junior investigators with a common research focus establish themselves as independent scientists. Achieving these goals will create a vibrant, synergistic research environment to comprehensively address the mechanisms of side effects of cancer therapy and to develop effective strategies to prevent such side effects. To our knowledge, few centers exist that focus on cancer survivors, and none take the paradigm-shifting approach of proactively addressing treatment-related toxicities. Specifically, this Center will provide an environment for young investigators to succeed as independent scientists (Aim 1); strengthen the overall research infrastructure at UAMS and the Cancer Institute (Aim 2); and ensure that the Center for Studies of Host Response to Cancer Therapy becomes self-sustaining (Aim 3). The four initial Project Leaders are promising new/early-stage investigators with their own active research programs and established collaborations with fellow Project Leaders and/or mentors. All are in the tenure track with their own research laboratories, and all have been provided generous institutional startup packages by their departments. Opportunities will be provided by implementing individualized mentoring and faculty development plans and by offering guidance and support from an administrative and two scientific cores. A high likelihood of success is ensured by strong institutional support combined with active interest from funding agencies in improving quality of life among cancer survivors. To replace Project Leaders who achieve independence and "graduate" from COBRE support, a "pipeline" of new Project Leaders is ensured through institutional support for recruitment of junior faculty, combined with a structured pilot project program. Building strong Center cores and collaborations with existing institutional cores will also contribute to establishing the Center for Studies of Host Response to Cancer Therapy as a self-sustaining center on campus. The Center's progress will be guided by External and Internal Advisory Committees and a Core Oversight Committee. The Internal Advisory Committee, comprised of individuals in key positions, with broad representation from across the institution and with a vested interest in the Center's achievements, will ensure the initial success of the Center as well as its long-term viability as an independent unit on campus.