2017 Cartilage Biology and Pathology Gordon Research Conference and Gordon Research Seminar

摘要 这是一个请求，以支持2017年戈登研究会议（GRC）和相关的戈登研究 研讨会（GRS）的Carcinoma生物学和病理学，这将是在伊尔Ciocco，意大利，从4月2日至7日，2017年举行。 全球风险理事会将是一系列非常成功的两年期会议中的第八次会议， 第二次是由GRS组织的，这是一次专门为学员组织的会前会议。关于GRC 生物学和病理学的成功归功于三个主要原则。首先，这是唯一一次 汇集了临床科学家，基础科学研究人员和生物医学工程师，并涵盖了 软骨生物学、相关病理学和与软骨相关的科学学科的全谱。 其次，作为GRC传统的例证，会议强调前瞻性思维，未发表的切割- 前沿发现和最先进的技术。它将正式演讲与海报会议交替进行， 非正式讨论，并将出席人数限制在200人。这是一个促进学院互动的论坛 以及建立富有成效的合作关系。第三，它对所有职业阶段的研究人员开放， 鼓励有抱负的年轻和资深调查人员之间的指导、网络和合作。这 最后一项原则在2015年得到了进一步的强调，增加了GRS，这是非常成功的。的 绝大多数参与者投票决定与2017年GRC一起举办第二次GRS。的 软骨生物学和病理学的GRC/GRS不仅是因为软骨是一个关键的 骨骼组织从发育到成年，但更重要的是，软骨畸形和 变性疾病影响大部分人的寿命和生活质量。此外，委员会认为， 软骨疾病在很大程度上仍然是不可治愈的，这主要是由于我们对分子和 这些疾病的细胞基础。研究以更好地了解软骨的原因和进展 因此，消除艾滋病毒/艾滋病并找到扭转和最终消除这些疾病的战略，是一个最高优先事项。为了帮助 改变软骨疾病的临床现实，GRC将突出最近的进展和挑战， 了解软骨疾病。GRC的首要主题是“了解生物学， 实现更好的软骨健康。”杰出的科学家和有前途的年轻研究人员将刺激 观众根据这一主题，并将提出最新的进展和剩余的挑战， 了解软骨生物学，疾病类型和翻译方法的各个方面。我们 预计2017年GRC/GRS的Carcinoma生物学和病理学，使跨学科的研究人员， 在改善患有各种软骨疾病的人的健康方面取得里程碑式的进展， 完成国立卫生研究院的使命。

ABSTRACT This is a request to support the 2017 Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) on Cartilage Biology and Pathology, which will be held in Il Ciocco, Italy, from April 2-7, 2017. The GRC will be the eighth in a series of highly successful biennial conferences, and it will be preceded for the second time by a GRS, a pre-meeting exclusively dedicated to and organized by trainees. The GRC on Cartilage Biology and Pathology owes its success to three major principles. First, it is the only conference that brings together clinicians-scientists, basic-science researchers and biomedical engineers, and covers the whole spectrum of cartilage biology, associated pathologies and scientific disciplines relevant to cartilage. Second, and exemplifying the GRC tradition, the conference emphasizes forward thinking, unpublished cutting- edge findings, and state-of-the-art technologies. It alternates formal presentations with poster sessions and informal discussions, and limits attendance to 200 participants. It is a forum that promotes collegial interactions and the establishment of productive collaborations. Third, it is open to researchers at all career stages and encourages mentoring, networking, and collaborations among aspirant, young and senior investigators. This last principle was further emphasized in 2015 with the addition of a GRS, which was highly successful. The overwhelming majority of participants voted to hold a second GRS, in conjunction with the 2017 GRC. The GRC/GRS on Cartilage Biology and Pathology are justified not merely by the fact that cartilage is a pivotal skeletal tissue from development to adulthood, but even more so by the fact that cartilage malformation and degeneration diseases affect the lifespan and quality of life of a large proportion of humans. Moreover, cartilage diseases remain largely incurable, largely due to our incomplete understanding of the molecular and cellular basis of these diseases. Research to better understand the causes and progression of cartilage diseases and to find strategies to reverse and ultimately eradicate them, is thus a top priority. In order to help change the clinical reality of cartilage diseases, the GRC will highlight recent advances and challenges in understanding cartilage diseases. The overarching theme of the GRC is entitled “Understanding biology to achieve better cartilage health.” Eminent scientists and promising young investigators will stimulate the audience according to this theme and will present the newest advances and remaining challenges towards understanding the various aspects of cartilage biology, disease types, and translational approaches. We expect the 2017 GRC/GRS on Cartilage Biology and Pathology to empower researchers across disciplines to make milestone progress towards improving the health of humans with all types of cartilage diseases, and thus fulfill the missions of the National Institutes of Health.