Dual-view endoscopic probe

 描述(申请人提供)：结肠癌是美国和海外癌症死亡的主要原因。结肠镜检查是首选的筛查方法，在美国估计每年的成本超过200亿美元。不幸的是，许多病变被漏掉了，因为癌前生长仍然隐藏在结肠的褶皱和弯曲后面。目前增加视野的方法是无效的，有些方法非常昂贵，这阻碍了这些方法的临床应用。一种专有的双视成像方法已经开发出来，它可以360度前后照明和成像，并产生单一图像。一个概念验证原型已经成功开发，但太大了，不能用于结肠镜检查。全知有限责任公司将从亚利桑那大学获得这种方法的许可，并建造一种双视角光学探头，该探头足够小，可以通过标准结肠镜检查的活检通道。全知有限责任公司将开发一种软件，将两种视角结合在一个视频显示中，并优化图像质量。该探头将在标准的结肠镜检查模型中进行测试，模拟息肉位于容易看到的区域以及那些隐藏在前方的区域。该探头将通过标准结肠镜的活检通道，其性能将与标准结肠镜单独进行比较。这一第一阶段STTR项目的成功完成将带来一种双视探头，该探头可以与标准结肠镜检查一起使用，并适合临床测试。

 DESCRIPTION (provided by applicant): Colon cancer is a leading cause of cancer death in the United States and overseas. Colonoscopy is the preferred screening method at an estimated annual cost of over $20 billion in the US. Unfortunately, many lesions are missed because pre-cancerous growths remain hidden from view behind folds and flexures of the colon. Current methods of increasing the field of view are ineffective and some are very expensive, which hampers adoption of these methods into clinical practice. A proprietary dual-view imaging method has been developed that illuminates and images forward as well as backwards in 360 degrees, and produces a single image. A proof of concept prototype has been successfully developed, but is too large to be used with a colonoscopy. Omniscient LLC will license the method from the University of Arizona and construct a dual-view optical probe that is small enough to be passed through the biopsy channel of a standard colonoscopy. Omniscient LLC will develop software which combines both views in a single video display and optimize image quality. The probe will be tested in standard colonoscopy models with simulated polyps in areas that are easy to see as well as those hidden from forward view. The probe will be passed through the biopsy channel of the standard colonoscopy and its performance will be compared to that of the standard colonoscopy alone. Successful completion of this Phase I STTR project will lead to a dual-view probe which can be used with standard colonoscopy and is suitable for clinical testing.