Morning Light Treatment at Home to Improve Glucose Metabolism in People at Increased Risk for Type 2 Diabetes
Morning Light Treatment at Home to Improve Glucose Metabolism in People at Increased Risk for Type 2 Diabetes
批准号:
9112207
负责人:
Helen Julia Burgess
金额:
$25.05万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-08-05 至 2016-11-30
关键词:
AdultAgeApneaBehavior TherapyBiological RhythmBody fatBoxingCircadian Rhythm Sleep DisordersCircadian RhythmsComplications of Diabetes MellitusConfounding Factors (Epidemiology)DataDevelopmentDevicesDiabetes MellitusDiseaseEnergy IntakeEnrollmentFemaleGlucoseGlycosylated hemoglobin AGoalsGrantHeadHealthHome environmentHourHumanImpairmentIndividualInsulinInterventionJet Lag SyndromeLaboratoriesLaboratory StudyLightMeasuresMediator of activation proteinMelatoninMethodsNon-Insulin-Dependent Diabetes MellitusOGTTObesityObstructive Sleep ApneaPatient Self-ReportPatientsPhasePhotoreceptorsPhototherapyPhysical activityPilot ProjectsPlacebosPopulationPrediabetes syndromeRaceRandomizedRandomized Clinical TrialsResearchResearch Project GrantsRiskSamplingSeasonal Affective DisorderSleepSleep FragmentationsStrategic PlanningTestingTimeTranslatingWristactigraphybaseblood glucose regulationclinical practiceclinically significantdiabetes riskfasting glucoseglucose metabolismglycemic controlimprovedindexinginnovationinsulin sensitivitylifestyle interventionmalenovelpreventpublic health relevanceresponsesexsocialtreatment group
中文摘要
英文摘要
DESCRIPTION (provided by applicant): Over 21 million US adults (~10% of the population) have type 2 diabetes mellitus (T2DM) and another 29 million have prediabetes. Targeting prediabetes to prevent the development of T2DM would have a substantial impact on the health of millions. Novel interventions to accomplish this are urgently needed. For this R21 Exploratory/Development grant, we propose to examine morning light treatment as a novel, safe, non- pharmacological intervention to improve glucose metabolism in people with prediabetes. The basis for this research is the recent evidence from both laboratory and population studies indicating that circadian misalignment is independently associated with increased risk for T2DM and poorer glucose control. We also have pilot data indicating later circadian timing (later dim light melatonin onset, DLMO) is significantly associated with a higher fasting glucose level. Here we propose to translate these findings into a novel behavioral intervention, morning light treatment, to improve glucose metabolism in people with prediabetes. To date, morning light treatment has been shown to reduce body fat, but glucose metabolism remains to be investigated. We will test a novel head worn light device (Re-Timer(r)) that reduces subject burden by allowing people to be ambulatory during light treatment. We include pilot data demonstrating our ability to measure compliance to light treatment. We will enroll 34 subjects (17 male, 17 female, ages 40-65 years), who will: (1) be obese (BMI>30 kg/m2), (2) have prediabetes (HbA1c 5.7% to <6.5%), (3) have significant circadian misalignment ("social jet lag" ≥ 2 h), and (4) be free of moderate to severe obstructive sleep apnea (apnea- hypopnea index<15). We will measure baseline sleep at home (wrist actigraphy) for 1 week, followed by a laboratory session to measure circadian timing (DLMO) and conduct a 3-hour (8-sample) oral glucose tolerance test (OGTT) in the morning. Subjects will then be randomized to 4 weeks of a 1 hour daily morning light treatment using either an active or placebo Re-timer(r). After 4 weeks of light treatment, the laboratory session will be repeated to reassess DLMO and OGTT. Specific Aim 1 is to determine the effect of active versus placebo morning light treatment on glucose metabolism in individuals with prediabetes. Specific Aim 2 is to determine the extent to which circadian phase advances are related to improvements in glucose metabolism. In an Exploratory Aim we will examine other possible mediators (body fat, activity, total caloric intake,
sleep fragmentation) that may also explain changes in glucose metabolism. Morning light treatment is already used by several patient groups and the light device is already commercially available. Thus a morning light treatment to improve glucose metabolism would readily translate into clinical practice, as a novel, safe, non-pharmacological intervention that could be added to other lifestyle interventions. This pilot study is the important first step towards the development
of a larger randomized clinical trial of morning light treatment to improve glucose metabolism.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Morning Light Treatment for Inflammatory Bowel Disease: A Pilot Clinical Trial
-
批准号:10710708
-
项目类别:
-
资助金额:$31.2万
-
财政年份:2023
-
负责人:Helen Julia Burgess
-
依托单位:
Morning Light Treatment for Traumatic Stress: the Role of Amygdala Reactivity
-
批准号:9807446
-
项目类别:
-
资助金额:$80.38万
-
财政年份:2019
-
负责人:Helen Julia Burgess
-
依托单位:
The Contribution of Sleep and Circadian Disruption to Kynurenine Pathway Activation and Cardiometabolic Risk in Women with HIV
-
批准号:10162654
-
项目类别:
-
资助金额:$46.28万
-
财政年份:2018
-
负责人:Helen Julia Burgess
-
依托单位:
Bright Light Treatment At Home To Improve Symptom Management of Fibromyalgia Syndrome
-
批准号:9794137
-
项目类别:
-
资助金额:$18.78万
-
财政年份:2018
-
负责人:Helen Julia Burgess
-
依托单位:
The Effect of Alcohol on Retinal Photic Signaling to the Human Circadian System
-
批准号:9298502
-
项目类别:
-
资助金额:$39.74万
-
财政年份:2016
-
负责人:Helen Julia Burgess
-
依托单位:
The Effect of Alcohol on Retinal Photic Signaling to the Human Circadian System
-
批准号:9028887
-
项目类别:
-
资助金额:$42.0万
-
财政年份:2016
-
负责人:Helen Julia Burgess
-
依托单位:
Bright Light Treatment At Home To Manage Chronic Pain In U.S. Veterans
-
批准号:8893901
-
项目类别:
-
资助金额:$22.55万
-
财政年份:2014
-
负责人:Helen Julia Burgess
-
依托单位:
Alcohol Alters the Circadian Response to Light in Humans
-
批准号:8580814
-
项目类别:
-
资助金额:$18.17万
-
财政年份:2013
-
负责人:Helen Julia Burgess
-
依托单位:
Alcohol Alters the Circadian Response to Light in Humans
-
批准号:8707908
-
项目类别:
-
资助金额:$21.33万
-
财政年份:2013
-
负责人:Helen Julia Burgess
-
依托单位:
Circadian Phase Assessments at Home
-
批准号:8496730
-
项目类别:
-
资助金额:$36.73万
-
财政年份:2011
-
负责人:Helen Julia Burgess
-
依托单位:
Circadian Phase Assessments at Home
-
批准号:8320891
-
项目类别:
-
资助金额:$37.87万
-
财政年份:2011
-
负责人:Helen Julia Burgess
-
依托单位:
Circadian Phase Assessments at Home
-
批准号:8179277
-
项目类别:
-
资助金额:$38.25万
-
财政年份:2011
-
负责人:Helen Julia Burgess
-
依托单位:
Sleep Length and Circadian Regulation in Humans
-
批准号:7842051
-
项目类别:
-
资助金额:$23.24万
-
财政年份:2009
-
负责人:Helen Julia Burgess
-
依托单位:
Sleep Length and Circadian Regulation in Humans
-
批准号:7341408
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2008
-
负责人:Helen Julia Burgess
-
依托单位:
Sleep Length and Circadian Regulation in Humans
-
批准号:7577527
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2008
-
负责人:Helen Julia Burgess
-
依托单位:
Sleep Length and Circadian Regulation in Humans
-
批准号:7786241
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2008
-
负责人:Helen Julia Burgess
-
依托单位:
Sleep Length and Circadian Regulation in Humans
-
批准号:8240451
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2008
-
负责人:Helen Julia Burgess
-
依托单位:
国内基金
海外基金
登录
查看更多内容
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
-
批准号:JCZRLH202601523
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
-
批准号:JCZRQN202500010
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:
-
依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
-
批准号:2025JJ70209
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:雷芬芳
-
依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
-
批准号:--
-
项目类别:面上项目
-
资助金额:--
-
批准年份:2024
-
负责人:万荣
-
依托单位:
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
-
批准号:2023JJ50274
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:贺志明
-
依托单位:
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
-
批准号:--
-
项目类别:地区科学基金项目
-
资助金额:33万元
-
批准年份:2022
-
负责人:都义日
-
依托单位:
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:叶宝东
-
依托单位:
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:于海兵
-
依托单位:
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
-
批准号:81973577
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2019
-
负责人:辛贵忠
-
依托单位:
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
-
批准号:81602908
-
项目类别:青年科学基金项目
-
资助金额:18.0万元
-
批准年份:2016
-
负责人:刘括
-
依托单位: