Statistics, computation and data sharing core

项目总结 核心C 核心C，即数据库、计算和统计核心，是方案项目职能的核心。它 从测序和微生物组分析核心以及生化和新陈代谢服务处接收数据 核心。将扩展现有的PPG数据库，以接收建议在#年期间收集的新数据。 下一个周期。将有两个人类和老鼠数据来源：杂交小鼠多样性小组和 来自芬兰的10,000名男性的MetSim队列。这些数据将被清理、管理和维护，以便 三个PPG项目，每个项目都将使用来自两个来源的数据。统计遗传学和基因组分析将 设计、实施和解释，以满足各自的具体目标。核心将与 每个预测都是定期进行的，以便以最有效率和最有效的方式进行分析 有可能。它将负责：1)数据存储、管理和检索；2)实施或教学 项目成员进行常规统计分析，例如比较 不同条件；3)需要研究设计、统计分析和解释的新颖分析 结果。核心部门将负责遵守任何有关数据的NIH政策 随着NIH规则的演变，提交到公开可用的数据库。

PROJECT SUMMARY Core C Core C, The Database, Computing and Statistics Core is central to the functions of the Program Project. It receives data from the Sequencing and Microbiome profiling Core and the Biochemical and Metabolic Services Core. An existing PPG database will be extended to receive the new data proposed for collection during the next cycle. There will be two sources of human and mouse data: the Hybrid Mouse Diversity Panel and the MetSim cohort of 10,000 men from Finland. These data will be cleaned, managed and maintained for the three PPG projects, and each will use data from both sources. Statistical genetics and genomic analyses will be designed, conducted and interpreted to satisfy the respective Specific Aims. The Core will interact with each projection a regular basis in order to conduct analyses in the most efficient and effective manner possible. It will be responsible for: 1) data storage, management and retrieval, 2) conducting or teaching project members to conduct routine statistical analyses such as comparing gene expression levels under different conditions, and 3) novel analyses that require study design, statistical analyses and interpretation of results. The Core will take responsibility for achieving compliance with any NIH policies regarding data submission to publicly available databases as the NIH rules evolve.