Statistics, computation and data sharing core

项目摘要 芯C 核心C，数据库，计算和统计核心是该计划项目的核心功能。它 接收来自测序和微生物组分析核心以及生化和代谢服务的数据 核心将扩展现有PPG数据库，以接收拟在研究期间收集的新数据。 next cycle.人类和小鼠数据将有两个来源：杂交小鼠多样性小组和 来自芬兰的10,000名男性的MetSim队列。这些数据将被清理、管理和维护， 三个PPG项目，每个项目都将使用来自两个来源的数据。统计遗传学和基因组分析将 设计、实施和解释应满足各自的具体目标。核心将与 定期对每项预测进行分析，以便以最有效率和效力的方式进行分析 可能它将负责：1）数据存储，管理和检索，2）进行或教学 项目成员进行常规的统计分析，如比较基因表达水平下， 不同的条件，和3）新的分析，需要研究设计，统计分析和解释 结果核心将负责遵守NIH关于数据的任何政策 随着NIH规则的发展，提交到公开可用的数据库。

PROJECT SUMMARY Core C Core C, The Database, Computing and Statistics Core is central to the functions of the Program Project. It receives data from the Sequencing and Microbiome profiling Core and the Biochemical and Metabolic Services Core. An existing PPG database will be extended to receive the new data proposed for collection during the next cycle. There will be two sources of human and mouse data: the Hybrid Mouse Diversity Panel and the MetSim cohort of 10,000 men from Finland. These data will be cleaned, managed and maintained for the three PPG projects, and each will use data from both sources. Statistical genetics and genomic analyses will be designed, conducted and interpreted to satisfy the respective Specific Aims. The Core will interact with each projection a regular basis in order to conduct analyses in the most efficient and effective manner possible. It will be responsible for: 1) data storage, management and retrieval, 2) conducting or teaching project members to conduct routine statistical analyses such as comparing gene expression levels under different conditions, and 3) novel analyses that require study design, statistical analyses and interpretation of results. The Core will take responsibility for achieving compliance with any NIH policies regarding data submission to publicly available databases as the NIH rules evolve.