An Administrative Core for the CaST Center

项目摘要 行政核心将协调和监督中心的所有活动。它将帮助 最大限度地发挥相互作用和协同作用，使现有的研究基础设施，如 中心最先进的高性能计算环境，方便中心参与 癌症系统生物学联盟（CSBC）的活动，确保来自 联合体活动被适当地纳入中心的研究计划，并管理试点研究 该基金将支持为期一年的中心内部研究项目，为整个中心的研究做出贡献 主题.将建立一个有效的管理结构，以确保实现这些目标， 包括一个执行指导委员会（由中心主任、项目经理和国家癌症研究所组成 项目官员），将建立该中心的方案的方向，并提供全面的指导;和 项目经理将经常与项目和核心领导会面，以确保计划的工作 按照时间表进行，操作问题得到迅速解决，软件、数据和 与CSBC联络，及时向公众发布项目活动生成的模型 根据需要建立数据中心。为进一步促进方案的有效整合， 核心委员会各成员之间的沟通，将组织每月会议，包括两部分： (i)研究报告，其中将包括所有计划参与者，和（ii）执行会议，这将是 仅限于执行指导委员会。后者将提供一个论坛，供坦率地评估项目 资源和目标的进展和优先次序。它还将提供一个机会， 与其他CSBC中心和相关NCI/NIH倡议的互动和合作。 行政核心的一项重要职能是通过管理 数据和资源、财务审查和预算分析、编写进度报告以及遵守 监管要求将任命一名合格的中心管理员协助中心的主任， 项目经理负责执行这些任务。核心将负责组建世界级的 科学外部咨询委员会（EAC）为中心的董事提供建议，并提供公正的 评估中心的研究计划。核心将组织年度审查会议， 选管会成员会就研究进展和未来方向提供意见，并就 方案管理和试点项目的行政管理。核心还将负责 定义和跟踪广泛的定量评价指标，以评估 中心的产品。最后，行政核心将协调中心人员参与所有 联合会活动，包括出席会议和讲习班，为工作组作出贡献， 技术委员会，并与其他NIH倡议接口。

PROJECT SUMMARY The Administrative Core will provide coordination and oversight across all Center activities. It will help maximize interactions and synergies, enable optimal use of available research infrastructure such as the Center's state-of-the-art High Performance Computing Environment, facilitate the participation of Center members to the activities of the Cancer Systems Biology Consortium (CSBC), ensure that input from Consortium activities is properly integrated into the Center's research program, and administer a pilot research fund which will support one-year intra-Center research projects contributing to the overall Center research theme. An effective management structure will be put in place to ensure that these objectives are achieved, including an Executive Steering Committee (comprising the Center's Directors, Project Manager, and NCI program officers) that will establish the direction of the Center's program and provide overall guidance; and a Project Manager who will meet frequently with project and core leads to ensure that planned work is proceeding according to schedule, that operational problems are quickly resolved, and that software, data, and models generated by project activities are released to the public in a timely manner, liaising with the CSBC Data Coordination Center as needed. To further promote integration of the program and effective communication among its various members, the Core will organize monthly meetings comprised of two parts: (i) research presentations, which will include all program participants, and (ii) executive meetings, which will be limited to the Executive Steering Committee. The latter will provide a forum for candid assessment of project progress and prioritization of resources and objectives. It will also offer an opportunity to explore possible interactions and collaborations with other CSBC Centers and related NCI/NIH initiatives. An important function of the Administrative Core will be to provide logistical support through management of data and resources, fiscal review and budget analysis, preparation of progress reports, and compliance with regulatory requirements. A qualified Center Administrator will be appointed to assist the Center's Directors and Project Manager with the execution of these tasks. The Core will be responsible for assembling a world class scientific External Advisory Committee (EAC) to advise the Center's Directors and to provide an impartial assessment of the Center's research program. The Core will organize an annual review meeting where the EAC members will be asked to offer feedback on research progress and future directions, as well as advice on program management and the administration of the pilot project progam. The Core will also be responsible for defining and tracking a broad collection of quantitative evaluation metrics to assess the quality and utility of the Center's products. Finally, the Administrative Core will coordinate the participation of Center personnel to all Consortium activities, including attending meetings and workshops, contributing to working groups and technical committees, and interfacing with other NIH initiatives.