MULTIGENOTYPIC AGED MOUSE COLONY

多基因型老年小鼠群体

• 批准号: 9352444
• 负责人: TERRY FISHER
• 金额: $ 58.71万
• 依托单位: CHARLES RIVER LABORATORIES INTNTL, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-10 至 2017-09-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9352444
• 关键词: Age; Aging; Aging-Related Process; Animal Model; Animals; Behavioral; Biological; Birth; Caloric Restriction; Contractor; Diet; Digit structure; Disease; Environment; Environmental Health; Genetic; Genetic Markers; Genotype; Health Status; Human; Hybrids; Inbreeding; Laboratory Animals; Lesion; Modeling; Monitor; Mus; Process; Research; Research Personnel; Rodent; Tail; Tattooing; age related; aged; fighting; open wound; programs; research study; sex; tumor

To develop, maintain and distribute a standing colony of aged, genetically defined caloric restricted mice for use by investigators in studies of aging. This colony is to be developed and maintained within controlled and defined barrier environments where animals are monitored and characterized for disease status and markers of genetic purity. Current and projected experiments using rodents to model the aging processes and age-related diseases in humans require animals of defined genotype and controlled environmental and health status. Only with the meticulous, long-term control of genetic and environmental variables is it possible to maintain relevant animal models that may be used to study many of the biological and behavioral processes in aging. Therefore, a continuous supply of genetically defined, well characterized inbred and hybrid laboratory animals is essential for a program of research on aging.

开发、维持和分发一个固定的老年、遗传定义的热量限制小鼠群体，供研究者用于衰老研究。该群体将在受控和规定的屏障环境中开发和维持，在该环境中监测动物的疾病状态和遗传纯度标记并对其进行表征。目前和计划中的实验使用啮齿动物来模拟人类的衰老过程和与年龄相关的疾病，需要确定的基因型和受控的环境和健康状况的动物。只有对遗传和环境变量进行细致的长期控制，才有可能维持相关的动物模型，这些模型可用于研究衰老过程中的许多生物和行为过程。因此，持续供应遗传上确定的、良好表征的近交系和杂交实验动物对于衰老研究计划至关重要。