Balance-Attention Interference Following Concussion

脑震荡后平衡注意力干扰

• 批准号: 8973544
• 负责人: Anthony P Kontos
• 金额: $ 14.8万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8973544
• 关键词: Address; Affect; Age; Anatomy; Arts; Assessment tool; Attention; Auditory; Award; Biomedical Engineering; Brain Concussion; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Clinical Research; Clinical assessments; Cognition; Collaborations; Communication; Consult; Control Groups; Counseling; Data; Development; Disease; Dizziness; Doctor of Philosophy; Effectiveness; Elderly; Emergency department visit; Environment; Equilibrium; Exercise; Functional disorder; Funding; Goals; Health; Individual; Institutes; Investigation; Kinesiology; Master of Science; Matched Group; Mentored Research Scientist Development Award; Mentors; Methods; Morbidity - disease rate; Neurobiology; Neuropsychological Tests; Orthopedic Surgery procedures; Otolaryngology; Outcome; Participant; Patients; Performance; Physical therapy; Physiology; Population; Procedures; Professional Organizations; Protocols documentation; Psychology; Reaction Time; Readiness; Recovery; Reporting; Research; Research Methodology; Research Personnel; Resources; Risk; Role; Science; Speed; Sports; Sports Medicine; Symptoms; System; Testing; Time; Training; Translational Research; Translations; United States National Institutes of Health; Universities; Vertigo; Visual; Vulnerable Populations; Work; aged; balance testing; career; certificate program; clinically relevant; cognitive task; cognitive testing; design; executive function; experience; insight; mid-career faculty; neurocognitive test; neuropsychological; novel; oculomotor; professor; programs; reduce symptoms; screening; sensory integration; sex; skills; somatosensory; symposium; young adult

DESCRIPTION (provided by applicant): Anthony P. Kontos, PhD, is Associate Professor and Assistant Director for Research in the UPMC Sports Medicine Concussion Program in the Department of Orthopaedic Surgery at the University of Pittsburgh. His academic background is in psychology and kinesiology. He has a Master of Science degree in exercise science, a Master of Arts in counseling psychology, and a PhD in kinesiology/sport psychology. His goal is to transition into the role of an independent investigator with the qualifications and experience necessary to design and implement translational investigations on vestibular and neuropsychological dysfunction and treatments in patients with concussion. During this K01 award, Dr. Kontos will gain experience and skills in vestibular and clinical neuropsychological testing methods. Dr. Kontos will be mentored in vestibular research methods by Dr. Furman from the Departments of Otolaryngology and Physical Therapy, and in neuropsychological research methods by Dr. Collins from the Department of Orthopaedic Surgery. Dr. Kontos will complete didactic coursework at the University of Pittsburgh in Neurobiology Systems with Dr. Simon and in the Clinical Translational Science Institute's Clinical Research certificate program. Dr. Kontos will also be mentored in directed study and consult with Dr. Carey Balaban, Professor of Otolaryngology, Neurobiology, Communication Sciences & Disorders and Bioengineering Director, Center for National Preparedness on vestibular anatomy and physiology; Dr. Neeraj Ghandi, Associate Professor of Otolaryngology on experimental and computational ocular-motor and sensory integration related vestibular function; Dr. Bill Yates, Professor of Otolaryngology on the role of the vestibular system in autonomic control; Dr. Redfern from the Departments of Bioengineering, Physical Therapy, and Otolaryngology regarding the use of attention-balance dual-task paradigms; and with Dr. Sparto regarding the acquisition and translation of balance data. During the award period, Dr. Kontos will gain the skills necessary to successfully complete the proposed research plan through a combination of coursework, directed research and clinical training, participation in professional organizations and symposia, and collaborations with his mentor and consultants. Specifically, Dr. Kontos will gain skills in assessing post-concussion vestibular dysfunction through the use of vestibular and neuropsychological assessment tools, and a novel dual-task visual reaction time/balance test paradigm. The Primary Aim of the proposed research plan is to investigate vestibular and neuropsychological dysfunction using a balance-attention dual-task paradigm among three well-defined groups of participants aged 13-20 years: 1) patients with concussion without vestibular dysfunction, 2) patients with concussion with vestibular dysfunction, and 3) healthy controls. Groups will be compared using a balance- attention dual-task paradigm that involves participants performing a visual reaction time task while standing on the ground and on a compliant foam pad. The extensive research environments and resources in both the Departments of Orthopaedic Surgery and Otolaryngology at the University of Pittsburgh will contribute significantly to the development of Dr. Kontos's career as an independent investigator focused on clinical/translational research of vestibular dysfunction in patients with concussion. The coursework in the CTSI certificate program will further enhance Dr. Kontos's ability to successfully conduct clinical/translational research involving patients with concussion and compete successfully for NIH-funding for his research. RELEVANCE The proposed study represents the first empirical investigation of a balance-attention dual-task paradigm to detect vestibular dysfunction in patients following concussion. The information from the proposed study will help inform concussion assessment and management strategies for clinicians working with this population.

描述（由申请人提供）：Anthony P. Kontos，博士，是匹兹堡大学矫形外科系UPMC运动医学脑震荡项目的副教授和研究助理主任。他的学术背景是心理学和运动机能学。他拥有运动科学硕士学位、咨询心理学硕士学位和运动机能学/运动心理学博士学位。他的目标是过渡到一个独立的研究者的角色，具有必要的资格和经验，设计和实施前庭和神经心理功能障碍和脑震荡患者的治疗翻译调查。Kontos博士将获得前庭和临床神经心理学测试方法的经验和技能。Kontos博士将由耳鼻喉科和物理治疗系的Furman博士指导前庭研究方法，并由骨科的柯林斯博士指导神经心理学研究方法。Kontos博士将与Simon博士一起在匹兹堡大学完成神经生物学系统的教学课程，并参加临床转化科学研究所的临床研究证书课程。Kontos博士还将在定向研究中接受指导，并与耳鼻喉科，神经生物学，通信科学和疾病教授以及前庭解剖学和生理学国家准备中心生物工程主任Carey Balaban博士进行咨询; Neeraj Ghandi博士，耳鼻喉科副教授，实验和计算眼运动和感觉整合相关的前庭功能; Bill Yates博士，耳鼻喉科教授，关于前庭系统在自主控制中的作用;来自生物工程，物理治疗和耳鼻喉科的Redfern博士关于注意力平衡双任务范式的使用;以及Sparto博士关于平衡数据的获取和翻译。在获奖期间，Kontos博士将获得必要的技能，通过课程作业，定向研究和临床培训，参与专业组织和研讨会，以及与他的导师和顾问合作，成功完成拟议的研究计划。Kontos将获得通过使用前庭和神经心理学评估工具评估脑震荡后前庭功能障碍的技能，以及一种新颖的双任务视觉反应时间/平衡测试范式。拟议研究计划的主要目的是使用平衡-注意力双任务范式在三组13-20岁的明确定义的参与者中研究前庭和神经心理功能障碍：1）无前庭功能障碍的脑震荡患者，2）前庭功能障碍的脑震荡患者，3）健康对照。将使用平衡-注意力双任务范式对各组进行比较，该范式涉及参与者在站在地面和顺应性泡沫垫上时执行视觉反应时间任务。匹兹堡大学矫形外科和耳鼻喉科两个部门的广泛研究环境和资源将为Kontos博士的职业生涯发展做出重大贡献，他是一名独立的研究人员，专注于脑震荡患者前庭功能障碍的临床/转化研究。CTSI证书课程的课程将进一步提高Kontos博士成功进行涉及脑震荡患者的临床/转化研究的能力，并成功地为他的研究争取NIH资金。相关性该研究代表了第一个实证调查的平衡注意力双任务范式，以检测前庭功能障碍的患者脑震荡。来自拟议研究的信息将有助于为与该人群一起工作的临床医生提供脑震荡评估和管理策略。