Balance-Attention Interference Following Concussion

脑震荡后平衡注意力干扰

• 批准号: 8441850
• 负责人: Anthony P Kontos
• 金额: $ 15.07万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441850
• 关键词: Accident and Emergency department; Address; Affect; Age; Anatomy; Arts; Attention; Auditory; Award; Biomedical Engineering; Brain Concussion; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Clinical Research; Clinical assessments; Cognition; Cognitive; Collaborations; Communication; Consult; Control Groups; Counseling; Data; Development; Disease; Dizziness; Doctor of Philosophy; Effectiveness; Elderly; Environment; Equilibrium; Exercise; Functional disorder; Funding; Goals; Health; Individual; Institutes; Investigation; Kinesiology; Master of Science; Matched Group; Mentored Research Scientist Development Award; Mentors; Methods; Morbidity - disease rate; Neurobiology; Neuropsychological Tests; Orthopedic Surgery procedures; Otolaryngology; Outcome; Participant; Patients; Performance; Physical therapy; Physiology; Population; Procedures; Professional Organizations; Protocols documentation; Psychology; Reaction Time; Readiness; Recovery; Reporting; Research; Research Methodology; Research Personnel; Resources; Risk; Role; Science; Speed; Sports; Sports Medicine; Symptoms; System; Testing; Time; Training; Translational Research; Translations; United States National Institutes of Health; Universities; Vertigo; Visit; Visual; Vulnerable Populations; Work; aged; balance testing; career; clinically relevant; design; executive function; experience; insight; neurocognitive test; neuropsychological; novel; oculomotor; professor; programs; public health relevance; screening; sensory integration; sex; skills; somatosensory; symposium; tool; young adult

DESCRIPTION (provided by applicant): Anthony P. Kontos, PhD, is Associate Professor and Assistant Director for Research in the UPMC Sports Medicine Concussion Program in the Department of Orthopaedic Surgery at the University of Pittsburgh. His academic background is in psychology and kinesiology. He has a Master of Science degree in exercise science, a Master of Arts in counseling psychology, and a PhD in kinesiology/sport psychology. His goal is to transition into the role of an independent investigator with the qualifications and experience necessary to design and implement translational investigations on vestibular and neuropsychological dysfunction and treatments in patients with concussion. During this K01 award, Dr. Kontos will gain experience and skills in vestibular and clinical neuropsychological testing methods. Dr. Kontos will be mentored in vestibular research methods by Dr. Furman from the Departments of Otolaryngology and Physical Therapy, and in neuropsychological research methods by Dr. Collins from the Department of Orthopaedic Surgery. Dr. Kontos will complete didactic coursework at the University of Pittsburgh in Neurobiology Systems with Dr. Simon and in the Clinical Translational Science Institute's Clinical Research certificate program. Dr. Kontos will also be mentored in directed study and consult with Dr. Carey Balaban, Professor of Otolaryngology, Neurobiology, Communication Sciences & Disorders and Bioengineering Director, Center for National Preparedness on vestibular anatomy and physiology; Dr. Neeraj Ghandi, Associate Professor of Otolaryngology on experimental and computational ocular-motor and sensory integration related vestibular function; Dr. Bill Yates, Professor of Otolaryngology on the role of the vestibular system in autonomic control; Dr. Redfern from the Departments of Bioengineering, Physical Therapy, and Otolaryngology regarding the use of attention-balance dual-task paradigms; and with Dr. Sparto regarding the acquisition and translation of balance data. During the award period, Dr. Kontos will gain the skills necessary to successfully complete the proposed research plan through a combination of coursework, directed research and clinical training, participation in professional organizations and symposia, and collaborations with his mentor and consultants. Specifically, Dr. Kontos will gain skills in assessing post-concussion vestibular dysfunction through the use of vestibular and neuropsychological assessment tools, and a novel dual-task visual reaction time/balance test paradigm. The Primary Aim of the proposed research plan is to investigate vestibular and neuropsychological dysfunction using a balance-attention dual-task paradigm among three well-defined groups of participants aged 13-20 years: 1) patients with concussion without vestibular dysfunction, 2) patients with concussion with vestibular dysfunction, and 3) healthy controls. Groups will be compared using a balance- attention dual-task paradigm that involves participants performing a visual reaction time task while standing on the ground and on a compliant foam pad. The extensive research environments and resources in both the Departments of Orthopaedic Surgery and Otolaryngology at the University of Pittsburgh will contribute significantly to the development of Dr. Kontos's career as an independent investigator focused on clinical/translational research of vestibular dysfunction in patients with concussion. The coursework in the CTSI certificate program will further enhance Dr. Kontos's ability to successfully conduct clinical/translational research involving patients with concussion and compete successfully for NIH-funding for his research. RELEVANCE The proposed study represents the first empirical investigation of a balance-attention dual-task paradigm to detect vestibular dysfunction in patients following concussion. The information from the proposed study will help inform concussion assessment and management strategies for clinicians working with this population.

描述(由申请人提供)：Anthony P.Kontos，博士，匹兹堡大学整形外科UPMC运动医学震荡项目副教授兼研究助理主任。他的学术背景是心理学和人体运动学。他拥有运动科学的理学硕士学位，咨询心理学的文学硕士学位，以及运动学/运动心理学的博士学位。他的目标是过渡到独立调查员的角色，拥有设计和实施关于脑震荡患者前庭和神经心理功能障碍和治疗的翻译性调查所需的资格和经验。在这个K01奖项期间，Kontos博士将获得前庭和临床神经心理测试方法方面的经验和技能。康托斯博士将接受耳鼻喉科和理疗科的福尔曼博士的前庭研究方法指导，整形外科的柯林斯博士将指导他的神经心理学研究方法。Kontos博士将在匹兹堡大学与Simon博士一起完成神经生物学系统的教学课程，并在临床翻译科学研究所的临床研究证书项目中完成教学工作。Kontos博士还将接受针对性研究的指导，并就前庭解剖和生理方面的国家准备中心生物工程主任、耳鼻喉科教授Carey Balaban教授、神经生物学、传播科学和疾病教授Carey Balaban博士、耳鼻喉科副教授Neeraj Ghandi博士就与前庭功能相关的实验性和计算性眼-运动和感觉整合问题向耳鼻喉科副教授Neeraj Ghandi博士进行指导；就前庭系统在自主神经控制中的作用向耳鼻喉科教授Bill Yates博士进行指导；就注意力平衡双重任务范式的使用与耳鼻喉科的Redfern博士进行咨询；以及就平衡数据的获取和翻译与Sparto博士进行磋商。在获奖期间，Kontos博士将通过课程作业、指导研究和临床培训、参加专业组织和研讨会以及与他的导师和顾问合作，获得成功完成拟议研究计划所需的技能。具体地说，Kontos博士将通过使用前庭和神经心理学评估工具，以及一种新的双重任务视觉反应时间/平衡测试范式，获得评估脑震荡后前庭功能障碍的技能。该研究计划的主要目的是使用平衡-注意双重任务范式在三组13-20岁的参与者中调查前庭和神经心理功能障碍：1)没有前庭功能障碍的脑震荡患者，2)脑震荡伴前庭功能障碍的患者，以及3)健康对照组。参与者将使用平衡注意力双重任务范式进行比较，包括站在地面上和在符合要求的泡沫垫上执行视觉反应时间任务。匹兹堡大学整形外科和耳鼻咽喉科广泛的研究环境和资源将对Kontos博士作为一名独立研究员的职业发展做出重大贡献，他专注于脑震荡患者前庭功能障碍的临床/转化性研究。CTSI证书项目中的课程将进一步增强Kontos博士成功进行涉及脑震荡患者的临床/转化性研究的能力，并成功竞争NIH资助他的研究的能力。相关性这项拟议的研究代表了首次对平衡注意力双重任务范式进行的经验性研究，以检测脑震荡后患者的前庭功能障碍。这项拟议研究的信息将有助于为从事这一人群工作的临床医生提供脑震荡评估和管理策略。