Optimal Strategy for Conservative Management of Prostate Cancer

前列腺癌保守治疗的最佳策略

• 批准号: 9129471
• 负责人: Stacy Loeb
• 金额: $ 17.81万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9129471
• 关键词: Address; Adverse effects; Award; Back; Benefits and Risks; Biopsy; Blood Tests; Cancer Patient; Characteristics; Clinical; Clinical Research; Collaborations; Consensus; Data; Decision Aid; Decision Making; Diagnosis; Digital Rectal Examination; Disease; Disease Progression; Early Diagnosis; Educational Curriculum; Ensure; Equilibrium; Erectile dysfunction; Evaluation; Fostering; Frequencies; Goals; Health; Health Services Research; Heterogeneity; Image; Incontinence; Individual; K-Series Research Career Programs; Knowledge; Lead; Life; Life Expectancy; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Mentorship; Methods; Modeling; Monitor; Online Systems; Operative Surgical Procedures; Patient Preferences; Patient observation; Patients; Physicians; Procedures; Prostate; Protocols documentation; Quality of life; Radiation; Research; Research Personnel; Research Training; Risk; Scientist; Screening for Prostate Cancer; Statistical Models; Symptoms; Testing; Tissues; Training; Treatment Cost; United States National Institutes of Health; Urologist; Visit; advanced disease; anticancer research; cancer care; career; clinical care; comparative effectiveness; compare effectiveness; cost; cost effective; cost effectiveness; curative treatments; design; experience; follow-up; improved; innovation; man; mathematical model; men; multidisciplinary; novel; personalized strategies; point of care; preference; programs; prostate biopsy; randomized trial; skills; support tools; symposium; systematic review; tool; tumor; web site

DESCRIPTION (provided by applicant): Dr. Stacy Loeb is an urologist with significant experience in clinical care and research on prostate cancer. This K07 award will allow the applicant to gain additional skills to foster a career as an independent investigator. This will be accomplished in collaboration with a multidisciplinary mentorship team. Background: One in 6 US men are diagnosed with prostate cancer during their lifetime but only 1 in 36 die from it. Treatment is often curative but may lead to side effects. An alternative option is conservative management, which delays or avoids the side effects of treatment. The major risk of conservative management is that the disease may progress without treatment. During conservative management, there are many options for follow-up testing to monitor for disease progression, ranging from blood tests and physical exams to imaging and biopsies. However, there is no consensus regarding the type, frequency and sequence of follow-up testing. More frequent and invasive tests may identify disease progression earlier, but may increase costs and complications. In a recent Consensus Conference, the NIH declared that identifying the optimal protocol for conservative management is a major priority in prostate cancer research. Project: The goal of this proposal is to compare the effectiveness, harms and costs of alternative strategies for conservative management using a mathematical model. The model will also look at the influence of patient features, tumor features, and preferences on the choice of strategy. This information will be distributed to prostate cancer patients and physicians through the preliminary design of a website. The research plan coincides with the applicant's proposed training curriculum, to ensure a successful bridge to submission of an R01 proposal. Mastery of these new skills will help the applicant transition into an independent cancer investigator with the capacity to compare the effectiveness and costs of new prostate cancer management options, and to design decision support tools for prostate cancer patients.

描述（由申请人提供）：Stacy Loeb博士是一名在临床护理和前列腺癌研究方面拥有丰富经验的泌尿科医生。该K07奖将使申请人能够获得额外的技能，以培养作为独立调查员的职业。这将是 与多学科指导团队合作完成。背景：六分之一的男性在一生中被诊断出患有前列腺癌，但只有36分之一的人死亡。治疗通常是治愈性的，但可能会导致副作用。另一种选择是保守管理，它延迟或避免了治疗的副作用。保守管理的主要风险是该疾病可能没有治疗而进展。在保守管理期间，有许多选择可用于监测疾病进展的后续测试，从血液检查和身体检查到成像和活检。但是，关于随访测试的类型，频率和顺序尚无共识。更频繁和侵入性的测试可能会更早地鉴定出疾病的进展，但可能会增加成本和并发症。在最近的共识会议中，NIH宣称，确定保守管理的最佳协议是前列腺癌研究的主要优先事项。项目：该提案的目标是比较使用数学模型的保守管理替代策略的有效性，危害和成本。该模型还将研究患者特征，肿瘤特征和偏好对策略选择的影响。该信息将通过网站的初步设计分发给前列腺癌患者和医生。该研究计划恰逢申请人提议的培训课程，以确保成功提交R01提案的桥梁。掌握这些新技能将有助于申请人过渡到独立的癌症研究者，以比较新的前列腺癌管理选择的有效性和成本，并为前列腺癌患者设计决策支持工具。