Increasing Activity Post-Kidney Transplant with SystemCHANGE

 描述(由申请人提供)：缺乏活动是老年肾移植受者的常见问题，可能会导致移植物丢失和心血管问题。然而，SystemCHANGE(Tm)+活动跟踪器的组合有望增加活动。这项以患者为导向的研究职业发展奖(K23)的短期目标是测试实施这些干预措施的可行性，并获得老年肾移植受者的初步数据。长期目标是将候选人培养为独立调查者，准备领导随机临床试验，重点是最大限度地增加老年慢性病患者的体力活动。这项研究的目的是：(I)评估对老年肾移植受者实施SystemCHANGE(Tm)+活动跟踪器干预的可行性，以及(Ii)确定SystemCHANGE(Tm)+活动跟踪器干预在多大程度上改善老年肾移植受者的体力活动和生活质量。44名65岁及以上的肾移植受者将从中南部移植中心招募，以确定可行性，包括可接受性、可用性和可持续性，并检查基线、1、2、3、6和12个月的STEP数据、功能能力、血压、心率、腰围和体重指数。拟议的培训符合NINR支持的倡议，代表着候选人先前研究培训的合乎逻辑的进步。职业发展目标是：(1)获得SystemCHANGE(Tm)干预和活动跟踪器技术方面的专业知识，(2)在肾移植领域建立强大的知识库和同事网络，(3)熟练使用统计技术来分析持续监测的数据，(4)发展进行随机临床试验的技能，(5)提高拨款/学术写作技能，以及(6)获得初步数据，以准备在大型随机对照试验中测试SystemCHANGE(Tm)+活动跟踪器干预的“R”级拨款。职业目标将通过授课课程、参加国家会议和研究所以及在肾移植(Hathaway和Russell)、SystemCHANGE(Tm)(Moore和Russell)、老年人体力活动(Resnick和Riceh)、临床试验(Russell)和定量方法(Hathaway)等领域有成就的科学家团队的指导下进行实践研究培训来实现。从这个职业发展奖中获得的技能、经验和数据将使候选人能够推进行为自我管理干预，重点是最大限度地增加老年慢性病患者的体力活动。

 DESCRIPTION (provided by applicant): Inactivity is a common problem among older kidney transplant recipients and may lead to graft loss and cardiovascular problems. However, the combination of SystemCHANGE(tm) + activity trackers holds promise for increasing activity. The short-term goals of this Mentored Patient-Oriented Research Career Development Award (K23) are to test the feasibility of implementing these interventions and obtain preliminary data on older adult kidney transplant recipients. The long-term goal is to develop the candidate as an independent investigator prepared to lead randomized clinical trials focused on maximizing physical activity among older chronically ill adults. The study aims are to: (I) evaluate feasibiliy of implementing the SystemCHANGE(tm) + activity tracker intervention with older adult kidney transplant recipients and (II) determine the degree to which a SystemCHANGE(tm) + activity tracker intervention improves physical activity and quality of life for older adult kidney transplat recipients. Forty-four kidney transplant recipients age 65 and older will be recruited from a mid-south transplant center to determine feasibility, including acceptability, usability, and sustainability, and to examine step-data, functional ability, blood pressure, heart rate, waist circumference, and body mass index at baseline, 1, 2, 3, 6, and 12 months. The proposed training is in line with NINR-supported initiatives and represents a logical progression from the candidate's prior research training. Career development objectives are to: (1) gain expertise with the SystemCHANGE(tm) intervention and activity tracker technology, (2) develop a strong knowledge base and network of colleagues in the field of kidney transplantation, (3) develop proficiency in the use of statistical techniques for analysis of continuously monitored data, (4) develop skills in conducting randomized clinical trials, (5) enhance grant/scholarly writing skills and (6) acquire preliminary data for preparation of an "R" Level grant to test the SystemCHANGE(tm) + activity tracker intervention in a large randomized control trial. Career objectives will be accomplished through didactic courses; participation in national conferences and institutes; and hands-on research training under the mentorship of an accomplished team of scientists in the field of kidney transplantation (Hathaway and Russell), SystemCHANGE(tm) (Moore and Russell), physical activity in older adults (Resnick and Richey), clinical trials (Russell), and quantitative methods (Hathaway). The skills, experience, and data gained from this career development award will position the candidate to advance behavioral self-management interventions focused on maximizing physical activity for older chronically ill adults.