Core E:Training Core

核心E：培训核心

• 批准号: 9043077
• 负责人: Michael D McClean
• 金额: $ 19.92万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9043077
• 关键词: Bioinformatics; Biological; Biological Sciences; Biology; Boston; Cell physiology; Communication; Communities; Complex; Computational Biology; Computational Science; Data Set; Development; Discipline; Ecology; Elements; Endocrine; Environmental Health; Exposure to; Foundations; Future; General Population; Goals; Government Agencies; Hazardous Waste Sites; Health; Institution; Instruction; Journalism; Knowledge; Laboratories; Life; Medical; Methods; Mission; Molecular Models; National Institute of Environmental Health Sciences; New England; Organism; Pathway interactions; Poison; Postdoctoral Fellow; Predisposition; Program Research Project Grants; Public Health; Reproduction; Research; Resources; Risk; Running; Science; Scientist; Signal Recognition Particle; Students; Techniques; Toxicology; Training; Training Programs; Training Support; Universities; Work; Writing; Xenobiotics; analytical method; base; cohort; college; developmental toxicity; genome-wide; graduate student; high throughput analysis; laboratory experience; member; molecular modeling; peer; peer networks; podcast; posters; programs; receptor; reproductive toxicity; science museum; skills; superfund chemical

This application proposes that the BU SRP Training Core will continue to provide interdisciplinary training in laboratory science, bioinformatics and computational biology, while also expanding the Training Core to act as a common reference point for all graduate students and post-doctoral fellows who work within the BU SRP program (including those who are supported by other BU SRP projects, other related training programs, and directly by the Training Core). The Training Core will directly support two students a year in bioinformatics techniques applied to the laboratory sciences, with an emphasis on analysis of high throughput, genome-wide data sets and on molecular modeling. This focus responds to the strategic importance of these methods for the biology of the future, the relative lack of exposure to them in traditional laboratory training programs, and the unique resources ofthe applicant institution. A major element ofthe program theme, the susceptibility ofthe developing organism to low-level xenobiotic exposures through a variety of pathways, is ideally suited to be the context for this cross discipline training. After nomination by project PIs at the end of their first year of study, two students will be selected by a Steering Committee consisting ofthe Program Director, the Training Core Director, and two additional BUSRP PIs, contingent on their commitment to one of the laboratories within the BUSRP. These students will receive appropriate core courses covering bioinformatics, reproduction and development, environmental health, and toxicology during their training program. In addition, we focus on communication skills, not only within the scientific community but to disseminate scientific knowledge to the broader community and to close the "communication gap" between bench and laboratory science and the public at large. Importantly, the Training Core will orient graduate students and post-doctoral fellows supported by BU SRP projects or the Training Core to the mission, activities and needs of the NIEHS SRP, EPA and state environmental and health agencies; and thereby develop a sense of shared mission and peer network as they work towards advancing the science needed to provide a firm foundation for solving the complex health and environmental issues associated with the nation's hazardous waste sites.

本申请建议BU SRP培训核心将继续提供以下跨学科培训： 实验室科学，生物信息学和计算生物学，同时也扩大了培训核心， 作为一个共同的参考点，为所有研究生和博士后研究员谁在BU工作 SRP项目（包括由其他BU SRP项目、其他相关培训项目支持的人员， 并直接由训练核心）。培训中心每年将直接支持两名学生， 生物信息学技术应用于实验室科学，重点是分析高 通量，全基因组数据集和分子建模。这一重点回应了战略 这些方法对未来生物学的重要性，传统生物学中相对缺乏对它们的接触， 实验室培训计划和申请机构的独特资源。一个主要的元素 节目主题，发展中的有机体的敏感性，低水平的外源性暴露，通过一个 多种途径，非常适合作为这种跨学科培训的背景。提名后 在第一年的学习结束时，两名学生将由指导委员会选出 由项目总监、培训核心总监和另外两名BUSRP PI组成， 他们对BUSRP中的一个实验室的承诺。这些学生将获得适当的核心 课程涵盖生物信息学，生殖和发展，环境健康和毒理学， 他们的训练计划。此外，我们注重沟通技巧，不仅在科学界 而是向更广泛的社区传播科学知识，缩小"沟通鸿沟"， 实验室科学和大众之间的关系。重要的是，培训核心将面向 由BU SRP项目或培训核心支持的研究生和博士后研究员 NIEHS SRP、EPA和州环境和健康机构的使命、活动和需求;以及 从而在他们致力于推进科学的过程中，培养一种共同的使命感和同行网络 需要为解决复杂的健康和环境问题提供坚实的基础， 国家的危险废物处理场