Research Capacity Building in Post Ebola Countries

埃博拉后国家的研究能力建设

• 批准号: 9229914
• 负责人: DONALD SAMUEL GRANT
• 金额: $ 5万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9229914
• 关键词: Address; Allied Health Sciences; Applications Grants; Clinical Research; Clinical Trials; Collaborations; Conduct Clinical Trials; Country; Disease Outbreaks; Ebola virus; Ensure; Epidemic; Future; Goals; Government; Grant; Health Professional; Health Services; Health system; Hospitals; Indigenous; Infectious Diseases Research; Institution; Investments; Knowledge; Lassa Fever; Medicine; Patients; Preparation; Process; Public Health; Qualifying; Recording of previous events; Research; Research Infrastructure; Research Training; Sierra Leone; System; Training; Training Programs; Translational Research; Universities; Viral Hemorrhagic Fevers; Virus Diseases; base; clinical investigation; college; design; experience; implementation science; improved; medical schools; pandemic disease; prospective; skills

The recent Ebola epidemic exposed the fragility of Sierra Leone´s health system and highlighted the inadequate investments to date that are needed to support a well-functioning system capable of responding to a disease outbreak of this magnitude. To improve delivery of quality health services for patients with endemic viral hemorrhagic fevers (VHF) such as Lassa fever (LF), while strengthening capacity to conduct clinical trials during future epidemic VHF outbreaks such as Ebola, Sierra Leone must grow its pool of qualified health professionals with the methodological skills in implementation science and the conduct of clinical trials. We have designed a comprehensive planning grant proposal that will allow us to evaluate existing research capacity of our in-country partner organizations, while refining our strategies for best approaches to address gaps in that capacity. Based on our combined extensive knowledge and history of conducting VHF research in Sierra Leone; as well as nearly two-decades of experience in managing institutional research, training, and capacity-building grants; we propose our expected research training plan. Upon completion of the planning grant period we fully expect to submit a competitive proposal that responds to the goals of the FIC Global Infectious Disease Research Training Program (D43). We seek to substantially advance implementation science research capacity at Sierra Leone´s principal medical school, the University of Sierra Leone College of Medicine and Allied Health Sciences (COMAHS); as well as clinical trial infrastructure at the Kenema Government Hospital (KGH) through the proposed Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) [pronounced “Prev Sil”]. Our Specific Aim during the D71 Planning Grant period is to promote sustainable clinical and translation research capacity in Sierra Leone that addresses emerging viral diseases, specifically Ebola, Lassa, and other VHF, that have regional and global pandemic potential by: 1) Conducting an assessment of existing research training capacity at COMAHS and its partnering institutions, in preparation of submission of a (D43); 2) Reinforcing administrative, managerial, and research collaboration ties between COMAHS and the training partners proposed; and 3) Finalizing a list of prospective trainee candidates and ensure the establishment of a recruitment and selection process for future trainees from Sierra Leone. Our subsequent D43 training program will consist of a combination of (1) long-term Masters training in clinical investigation or public health at Vanderbilt; (2) short- to medium-term clinical trial management training that reinforces south-south collaborations and builds regional networks; (3) short and long-term capacity building in health services implementation science research; and (4) sustainable, indigenous capacity building at COMAHS for the management and administration of future research grant opportunities.

最近的埃博拉疫情暴露了塞拉利昂卫生系统的脆弱性 并强调了迄今为止支持一个运作良好的系统所需的投资不足 有能力应对这种规模的疾病爆发。改善优质保健服务的提供 对于拉沙热（LF）等地方性病毒性出血热（VHF）患者，同时加强 在未来埃博拉等流行性VHF疫情期间进行临床试验的能力，塞拉利昂必须增长 拥有实施科学方法技能的合格卫生专业人员人才库， 进行临床试验。 我们已经设计了一个全面的规划拨款建议，这将使我们能够评估现有的研究 我们的国内伙伴组织的能力，同时完善我们的战略，以最佳方式解决 这种能力的差距。基于我们的综合广泛的知识和历史进行甚高频研究， 塞拉利昂;以及近二十年的管理机构研究，培训和 能力建设赠款;我们提出预期的研究培训计划。规划完成后 在赠款期间，我们完全期望提交一份符合FIC Global目标的有竞争力的提案 传染病研究培训方案（D43）。 我们寻求大幅提高塞拉利昂主要国家的实施科学研究能力。 塞拉利昂大学医学与联合健康科学学院（COMAHS）; 以及凯内马政府医院（KGH）的临床试验基础设施 塞拉利昂新兴病毒预防研究伙伴关系（PREVSL）。 我们在D 71规划补助金期间的具体目标是促进可持续的临床和翻译 塞拉利昂应对新出现的病毒性疾病的研究能力，特别是埃博拉病毒、拉沙病毒和其他 通过以下方式，对具有区域和全球大流行潜力的甚高频进行评估：1）对现有研究进行评估 培训COMAHS及其伙伴机构的能力，以准备提交（D43）; 2)加强COMAHS和培训之间的行政，管理和研究合作关系 3）最后确定潜在受训人员候选人名单，并确保建立一个 为今后来自塞拉利昂的受训人员进行征聘和甄选。 我们随后的D43培训计划将包括（1）长期的临床硕士培训， 调查或公共卫生在范德比尔特;（2）短期至中期临床试验管理培训， 加强南南合作，建立区域网络;（3）在以下领域开展短期和长期能力建设： 卫生服务实施科学研究;（4）可持续的本地能力建设， COMAHS用于管理和管理未来的研究资助机会。