Point-of-Care Rapid RNA Diagnosis of Influenza Virus

流感病毒的即时护理快速 RNA 诊断

• 批准号: 9136027
• 负责人: HyunDae Cho
• 金额: $ 30.66万
• 依托单位: CROSSLIFE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9136027
• 关键词: Animals; Antibodies; Biological Assay; Cellular Phone; Clinical; Consult; Decision Making; Detection; Development; Devices; Diagnosis; Diagnostic; Economic Burden; Emerging Communicable Diseases; Enzymes; Epidemic; Equipment; Flu virus; Genes; Gold; HIV; Health Care Costs; Hospitals; Human; Immobilization; In Vitro; Influenza; Influenza A Virus, H1N1 Subtype; Influenza A virus; Influenza B Virus; Intervention; Lateral; Methods; Molecular; Molecular Diagnosis; Nucleic Acid Amplification Tests; Nucleic Acids; Paper; Performance; Phase; Population; Pregnancy Tests; Productivity; Public Health; RNA; RNA Sequences; RNA purification; Reaction; Risk Assessment; Sampling; Severe Acute Respiratory Syndrome; Signal Transduction; Silver; Specificity; System; Technology; Testing; Titrations; Transcript; Viral; Virus; Wisconsin; World Health Organization; amplification detection; assay development; base; chemical transfer reaction; cost; design; flexibility; flu; imaging software; improved; influenzavirus; innovation; instrumentation; medical schools; nanoparticle; pandemic disease; pathogen; point of care; point-of-care diagnostics; public health relevance; user-friendly; viral RNA

 DESCRIPTION (provided by applicant): Influenza rapidly spreads around the world in seasonal epidemics and imposes a considerable economic burden in the form of hospital and other health care costs and lost productivity [1, 2]. Early prediction, detection, characterization and risk assessment of viruses in their animal hosts, before they spread into the human population, are critical to protect public health [3, 4]. Global burdens from existing or emerging infectious diseases emphasize the need for a point-of-care (POC) diagnostics to enhance timely recognition and intervention [5]. To better prepare for the next pandemic, we need to develop simple and easy-to-use tests for characterizing newly emerging influenza viruses and needs of point of care flu diagnostic devices at low cost with a multiplex platform [5]. A highly sensitive, simple paper strip molecular test that detects the Influenza virus at the point-of-care will be developed.