Effect of Cook Stove Exposure on Adverse Pregnancy Outcomes and Infant ALRI

炉灶暴露对不良妊娠结局和婴儿 ALRI 的影响

• 批准号: 9151637
• 负责人: Khandaker Talat S Islam
• 金额: $ 13.65万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-23 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9151637
• 关键词: 5 year old; Accounting; Acute; Address; Air Pollutants; Air Pollution; Area; Aromatic Polycyclic Hydrocarbons; Arsenic; Award; Bangladesh; Biological; Biological Markers; Biomass; Birth; Blood specimen; Carbon Black; Carbon Monoxide; Cellular Phone; Cessation of life; Characteristics; Child; Childhood; Complex Mixtures; Cookstove; DNA Adducts; Developing Countries; Development; Development Plans; Disease; Doctor of Philosophy; Dose; Environmental Exposure; Environmental Health; Environmental air flow; Epidemiologic Studies; Epidemiologist; Epigenetic Process; Event; Exposure to; Fetal Growth Retardation; Fostering; Future; Gases; Gestational Age; Grant; Health; Heating; High Prevalence; Home environment; Hour; Household Air Pollution; Incidence; Infant; Infant Mortality; Institution; International; Investigation; Joints; K-Series Research Career Programs; Knowledge; Lead; Life; Link; Liquid substance; Live Birth; Low Birth Weight Infant; Lower Respiratory Tract Infection; Malnutrition; Maternal Exposure; Maternal and Child Health; Measurement; Measures; Mentors; Mentorship; Modeling; Monitor; Mothers; Muslim religion; Neonatal Mortality; Newborn Infant; Nitrogen Oxides; Outcome; Particulate Matter; Perinatal Epidemiology; Pneumonia; Population; Predisposition; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Prevalence; Production; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Risk; Rural; Severities; Small for Gestational Age Infant; Smoke; Source; Specimen; Structure; Surveillance Program; System; Time; Training; Ultrasonography; Umbilical Cord Blood; Urine; Woman; Work; adverse outcome; adverse pregnancy outcome; base; biomass fuel; cohort; combustion product; cooking; cost effective; drinking water; experience; fetal blood; field study; gene environment interaction; global environment; improved; infant morbidity/mortality; innovation; international center; laboratory experience; low and middle-income countries; mortality; novel; pollutant; reproductive epidemiology; respiratory health; skills; trafficking

 DESCRIPTION (provided by applicant): Talat Islam, MBBS, Ph.D., is an environmental epidemiologist with a strong track record in studying the effect of genes and environment on respiratory health outcomes in children. The purpose of this K01 IRSDA application is for Dr. Islam to build on his background and extend his expertise to conduct international research in maternal and child health through training in exposure assessment, and reproductive and perinatal epidemiology. The scientific aims of this proposal are based on the findings that exposure to biomass fuel smoke from traditional cook stoves can lead to adverse pregnancy outcomes and acute lower respiratory tract infection (ALRI) in children. Adverse pregnancy outcomes and ALRI are major threats to maternal and child health in Bangladesh. The prevalence of low birth weight (LBW-53%), small-for-gestational age (SGA-70%) and pre-term birth (<37 weeks-22.5%) is high in Bangladesh. One in every 19 children born in Bangladesh dies before their 1stbirthday and ALRI accounts for more than 50% of the infant mortality. Environmental exposures including air pollution from cook stoves and arsenic (As) from drinking water can contribute to these adverse outcomes. The prevalence of biomass fuel (BMF) used for cooking is 88%, and exposure to >10μgm/l As in drinking water is common (33%) in Bangladesh. Therefore, the major aim of this proposal is to investigate the effect of maternal exposure to biomass combustion products on pregnancy outcomes and ALRI incidence during the first 6 months of life in Bangladesh. We also propose to explore the joint effect of biomass combustion exposure and As exposure on those outcomes. A key innovation is the development of an exposure model for black carbon (BC), product of incomplete combustion of BMF, using cost-effective novel monitors suitable for large epidemiological studies in LMIC settings. We will also measure Hb-DNA adducts of polycyclic aromatic hydrocarbons (PAH) in the cord blood of a sub-population of new-born as a biologically effective dose for exposure to PAHs and investigate its possible link to study health outcomes and maternal exposure to BMF. Successful completion of these aims builds on the expertise of the candidate and extends it to exposure assessment and reproductive and perinatal epidemiology in a global research setting that requires additional training and mentorship. The candidate will attain the necessary expertise by working with experts in the relevant fields, through formal course work, structured mentored training and laboratory work. [This project will take advantage of the available infrastructure in Bangladesh through the highly respected LMIC research institution, International Center for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) that will enable the candidate to establish a pregnancy cohort of 900 women and follow the newborns for six month at a cost effective efficient manner.] This grant, beyond providing the necessary training to the candidate to be established as an independent international researcher, will address important gaps in evidence on the effects of cook stove exposure on maternal and child health, and will provide a resource for future studies.