CRCNS:Subject-Specific Difusion MRI Profiles of Injury in TBI and PTSD
CRCNS:Subject-Specific Difusion MRI Profiles of Injury in TBI and PTSD
批准号:
9241597
负责人:
Sylvain Bouix
金额:
$27.01万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-08-14 至 2019-05-31
关键词:
AccountingAlgorithmsAnxietyAtlasesBehavioralBrainBrain InjuriesClinicalClinical MarkersClinical ResearchCognitiveComplexDataData SetDetectionDiagnosisDiffusion Magnetic Resonance ImagingDiseaseEnsureFiberGoalsImageImaging DeviceInjuryInstructionLabelLearningLinkLocationMRI ScansMagnetic Resonance ImagingMapsMeasurementMeasuresMedical ImagingMeta-AnalysisMethodsModalityModelingMonitorNeurobehavioral ManifestationsOutputPathologyPatientsPatternPopulationPost-Traumatic Stress DisordersPrincipal InvestigatorProbabilityProcessReadingRecoveryRecruitment ActivityReportingResearchSample SizeScanningSensitivity and SpecificitySeveritiesSignal TransductionSiteStagingStatistical ModelsStructureStudy SubjectTechniquesTechnologyTestingTraumatic Brain InjuryTreatment Efficacyage groupbasebrain abnormalitiesclinical caredesignexperiencehuman dataimage processingimaging biomarkerimaging modalityindexinginterestmild traumatic brain injuryneuroimagingneuropsychologicalnew technologynovelprocessing speedprogramssymptomatologytool
中文摘要
虽然轻度创伤性脑损伤(mTBI)已成为许多神经影像学研究的焦点,但它的临床应用前景并不理想
英文摘要
While mild traumatic brain injury (mTBI) has become the focus of many neuroimaging studies, the
understanding of mTBI, particularly in patients who evince no radiological evidence of injury and yet
experience clinical and cognitive symptoms, has remained a complex challenge. Sophisticated imaging tools
are needed to delineate the kind of subtle brain injury that is extant in these patients, as existing tools are
often ill-suited for the diagnosis of mTBI. For example, conventional magnetic resonance imaging (MRI)
studies have focused on seeking a spatially consistent pattern of abnormal signal using statistical analyses
that compare average differences between groups, i.e., separating mTBI from healthy controls. While these
methods are successful in many diseases, they are not as useful in mTBI, where brain injuries are spatially
heterogeneous.
The goal of this proposal is to develop a robust framework to perform subject-specific neuroimaging
analyses of Diffusion MRI (dMRI), as this modality has shown excellent sensitivity to brain injuries and can
locate subtle brain abnormalities that are not detected using routine clinical neuroradiological readings. New
algorithms will be developed to create Individualized Brain Abnormality (IBA) maps that will have a number
of clinical and research applications. In this proposal, this technology will be used to analyze a previously
acquired dataset from the INTRuST Clinical Consortium, a multi-center effort to study subjects with Post-
Traumatic Stress Disorder (PTSD) and mTBI. Neuroimaging abnormality measures will be linked to clinical
and neuropsychological assessments. This technique will allow us to tease apart neuroimaging differences
between PTSD and mTBI and to establish baseline relationships between neuroimaging markers, and
clinical and cognitive measures.
Upon completion of this project, a set of tools, which have the potential to establish radiological evidence of
brain injury in mTBI, will have been designed and evaluated, thereby enhancing both the diagnosis and
monitoring of progression/recovery of injury, as well assessing the efficacy of therapies on the injured brain.
RELEVANCE (See instructions):
One major limitation to standard clinical care is that imaging methods used routinely for diagnosis are not
sensitive enough to detect the subtle pathologies of mild Traumatic Brain Injury (mTBI). The overarching
goal of this proposal is to design tools to create individualized brain injury maps from diffusion MRI that can
detect these subtle abnormalities, and help establish a link between imaging and symptomatology in mTBI.
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会议论文
High Resolution, Comprehensive Atlases of the Human Brain Morphology
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批准号:10165186
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项目类别:
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资助金额:$26.85万
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财政年份:2020
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负责人:Sylvain Bouix
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依托单位:
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批准号:10053340
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项目类别:
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资助金额:$75.55万
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财政年份:2017
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依托单位:
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批准号:10318144
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项目类别:
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资助金额:$75.55万
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财政年份:2017
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负责人:Sylvain Bouix
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依托单位:
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批准号:8063954
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项目类别:
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资助金额:$43.16万
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财政年份:2009
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负责人:Sylvain Bouix
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依托单位:
Computational Morphometry in Schizophrenia and Related Disorders
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批准号:8257182
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项目类别:
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资助金额:$43.14万
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财政年份:2009
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负责人:Sylvain Bouix
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依托单位:
Computational Morphometry in Schizophrenia and Related Disorders
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批准号:7727105
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项目类别:
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资助金额:$44.4万
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财政年份:2009
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负责人:Sylvain Bouix
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依托单位:
Computational Morphometry in Schizophrenia and Related Disorders
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批准号:8432454
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项目类别:
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资助金额:$41.41万
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财政年份:2009
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负责人:Sylvain Bouix
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依托单位:
Computational Morphometry in Schizophrenia and Related Disorders
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批准号:7862376
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项目类别:
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资助金额:$43.96万
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财政年份:2009
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负责人:Sylvain Bouix
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依托单位:
海外基金