Research Antibodies: Solutions for Today and Tomorrow

研究抗体：今天和明天的解决方案

• 批准号: 9194547
• 负责人: Leonard Paul Freedman
• 金额: $ 4.77万
• 依托单位: GLOBAL BIOLOGICAL STANDARDS INSTITUTE, L
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-16 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9194547
• 关键词: Academia; Address; Adopted; Adoption; Antibodies; Applications Grants; Biological; Biological Assay; Biological Sciences; Biomedical Research; California; Certification; Committee Members; Communities; Consensus; Contractor; Data; Development; Diagnostic; Educational workshop; Ensure; Funding; Human; Industry; Institutes; International; Journals; National Institute of General Medical Sciences; Paper; Participant; Performance; Policies; Process; Proteome; Publishing; Reagent; Recombinant Antibody; Recombinant DNA; Recombinants; Recommendation; Reproducibility; Research; Seminal; Services; Societies; Specificity; Speed; Standardization; System; TimeLine; Translations; United States National Institutes of Health; Validation; Variant; abstracting; base; follow-up; improved; meetings; pre-clinical research; research study; symposium; working group

Project Summary/Abstract Antibodies are indispensable biological reagents around the world, yet are a major contributor to the current reproducibility crisis in preclinical research. A variety of issues can jeopardize antibody-based biomedical experiments, while the inability to replicate published data can often be traced to antibodies that were not properly validated. This NIH/NIGMS Research Conference (R13) Grant proposal will help fund a workshop co-sponsored and co-hosted by the Global Biological Standards Institute and The Antibody Society on September 25–27, 2016, at the Asilomar Conference Grounds in Pacific Grove, California. The workshop will be a central part of a year-long process that will engage key experts and stakeholder group representatives to examine and propose potential solutions that can be adopted across the life sciences. The meeting will focus on critical issues in the field, including standardization of characterization, performance, and validation of antibodies, as well as the introduction of recombinant, sequenced antibodies as a long-term potential path forward to improving the quality, reproducibility, and translation of antibody-based preclinical research. Approximately 80 workshop participants are planned, including 7 Steering Committee members, 38 panelists across 8 panels, 30 additional expert participants, and 5 staff and contractors. The workshop and related products will help the broader life science research community reach consensus around both short- and long-term solutions to address the pervasive lack of well characterized and validated antibodies in biomedical research.

项目总结/摘要 抗体是全世界不可或缺的生物试剂，但也是免疫反应的主要贡献者。 当前临床前研究中的再现性危机。各种各样的问题可能会危及 基于抗体的生物医学实验，而无法复制已发表的数据， 可以追溯到未经适当验证的抗体。NIH/NIGMS研究会议 (R13)赠款提案将帮助资助一个讲习班共同赞助和共同主办的全球 2016年9月25日至27日，生物标准协会和抗体协会在 阿西洛马会议场地在太平洋格罗夫，加州。研讨会将是一个中心部分， 一个为期一年的进程，将使主要专家和利益攸关方团体代表参与， 研究并提出可以在生命科学中采用的潜在解决方案。的 会议将重点讨论该领域的关键问题，包括特征描述的标准化， 性能和抗体的验证，以及重组体的引入， 测序抗体作为一个长期的潜在途径，以提高质量， 重现性和基于抗体的临床前研究的转化。约80 计划参加讲习班，包括7名指导委员会成员，38名小组成员 8个小组、另外30名专家与会者以及5名工作人员和承包商。讲习班 和相关产品将有助于更广泛的生命科学研究界达成共识 围绕短期和长期解决方案，以解决普遍缺乏 以及生物医学研究中经过验证的抗体。