Numerical Investigation of anatomical structure and material property of vocal fold on phonation

声带解剖结构和材料特性对发声影响的数值研究

• 批准号: 9147567
• 负责人: Qian Xue
• 金额: $ 14.05万
• 依托单位: UNIVERSITY OF MAINE ORONO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-22 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9147567
• 关键词: Acoustics; Affect; Age; Anatomy; Biocompatible Materials; Characteristics; Clinical Research; Complex; Conus genus; Development; Elements; Engineering; Frequencies; Future; Gender; Geometry; Goals; Health; Human; Investigation; Lamina Propria; Ligaments; Link; Measurable; Mechanics; Medial; Methods; Modeling; Mucous Membrane; Muscle; Noise; Outcome; Performance; Phonation; Property; Prosthesis; Race; Series; Signal Transduction; Source; Speed; Structure; Surface; Thick; Tissues; Variant; Voice; base; clinical application; clinically relevant; curve fitting; improved; insight; kinematics; pressure; simulation; sound; vibration; vocal cord

 DESCRIPTION (provided by applicant): Based on its mechanical properties, human vocal fold can be divided into three layers: mucosa plus superficial layer of lamina propria (Reinke's space), ligament, and muscle. The geometry and material properties of these layers determine vocal fold vibratory characteristics. Although the importance of the multilayered structure of vocal fold has long been recognized, the understanding of how the variations of the geometry and material properties of vocal fold layers affect phonation is still very limited. Improving such understanding would benefit both voice treatment and clinical research. For example, it could allow us to predict/estimate the impact of tissue damage, i.e. stiffening of the superficial layers of the vocal fold, and the placement of injected biomaterials. It could also assist the development of engineering vocal fold tissue and prosthesis for replacing damaged tissue. Knowing what geometry and material properties that phonation is most sensitive to could also be valuable for future model creation or model complexity reduction. The PIs propose to utilize a high performance, three-dimensional continuum mechanics based flow-structure interaction model to systematically examine and quantify the effects of geometry and material properties of vocal fold layers on phonation. The study aims to identify the geometry and material properties of vocal fold layers that phonation is most sensitive to, and understand how the variations of these properties affect vocal fold vibration and voice. The long term goal is to establish a direct cause-effect link between vocal fold anatomy (geometry and material properties) and phonation. The two specific aims are as follows: (1) investigate the effects of geometry of vocal fold layers on vibratory dynamics, aerodynamics and sound sources; (2) investigate the effects of material properties of vocal fold layers on vibratory dynamics, aerodynamics and sound sources.

 描述（申请人提供）：根据其机械特性，人声襞可分为三层：粘膜加上固有层浅层（赖因克间隙）、韧带和肌肉。这些层的几何形状和材料特性决定了声带振动特性。尽管声带多层结构的重要性早已被认识到，但对声带层的几何形状和材料特性的变化如何影响发声的理解仍然非常有限。改进这样的 理解将有利于声音治疗和临床研究。例如，它可以让我们预测/估计组织损伤的影响，即表层的硬化 声带的形状，以及注射生物材料的放置。它还可以帮助开发工程声带组织和替代受损组织的假体。了解发声对哪些几何形状和材料特性最敏感对于未来的模型创建或降低模型复杂性也很有价值。 PI 提议利用基于高性能、三维连续介质力学的流结构相互作用模型来系统地检查和量化声带层的几何形状和材料特性对发声的影响。该研究旨在确定发声最敏感的声带层的几何形状和材料特性，并了解这些特性的变化如何影响声带振动和声音。长期目标是建立直接 声带解剖结构（几何形状和材料特性）与发声之间的因果关系。两个具体目标如下：（1）研究声带层的几何形状对振动动力学、空气动力学和声源的影响； (2)研究声带层材料特性对振动动力学、空气动力学和声源的影响。