Training of the Pediatric Emergency Physician-Scientist

描述(由申请人提供)：这是NICHD儿科急诊医学机构培训补助金的第一次续签申请，旨在为华盛顿大学圣路易斯医学院(WUMS)的儿科系提供必要的资金，以招聘和培养合格的内科科学家。我们的长期目标是利用这笔资金促进年轻内科科学家的职业发展，他们将成为生物医学研究工作的未来领导者，致力于改善患有紧急医疗条件的儿童的健康结果。这项提议的具体目的是在实习结束时确定潜在的受训人员，并为他们提供两年的实验室研究经验，由合格的导师指导，或提供相对严格的以病人为导向的指导研究经验，从而免除临床和教学责任。研究的重点将是儿科急救医学中的儿童健康问题，包括高度优先的以患者为导向的研究，重点是灾难性疾病、紧急护理和长期残疾之间的关系。我们还将强调感染和免疫的分子机制，以及创伤性或非创伤性休克状态引起的多器官功能障碍综合征(MODS)。我们将通过创建两个轨道来实现这一目标：(1)以患者为中心的研究，以及(2)感染、免疫和MODS的分子机制。细胞、分子和发育生物学的最新进展将应用于了解感染、免疫和MODS的发病机制和治疗。同样，将采用严格的以患者为中心的研究方法，利用WUMS及其儿科部门的全部设施，改善高度优先的紧急内外科疾病的结果。我们已经建立了一个结构，在这个结构中，聪明、有动力的年轻儿科医生将在受保护的环境中茁壮成长，并将成为这一不断发展的儿科专科领域的领导者。我们计划每年招收一名博士后，为期5年。每名研究员的拟议培训期限为2年。该项目利用了25名资深调查人员，他们将担任导师。随着其受训人员在未来20年或更长时间内为儿科急诊医生-科学家的发展和领导力做出贡献，长期目标将实现。

DESCRIPTION (provided by applicant): This is the first renewal submission of an application for an NICHD Institutional Training Grant in Pediatric Emergency Medicine intended to provide the Department of Pediatrics at Washington University in St. Louis School of Medicine (WUMS) with the funds necessary to recruit and educate qualified physician-scientists. Our long-term objective is to use this funding to promote the career development of young physician scientists who will become future leaders in biomedical research efforts dedicated to improving health outcomes for children with emergency medical conditions. The specific aims of this proposal are to identify potential trainees at the completion of their residency and to provide them with a two-year research experience in the laboratory of a qualified mentor or with a comparably rigorous mentored patient-oriented research experience, protected from clinical and teaching responsibilities. The focus of the research will be on child health issues in pediatric emergency medicine, including high-priority patient-oriented research with emphasis on the relationship between catastrophic illness, emergency care and long-term disabilities. We will also emphasize molecular mechanisms of infection and immunity, and multiple organ dysfunction syndrome (MODS) arising from traumatic or non-traumatic shock states. We will achieve this goal by creating two tracks: (1) patient-oriented research, and (2) the molecular mechanisms of infection, immunity, and MODS. Recent advances in cell, molecular, and developmental biology will be applied to understanding the pathogenesis and treatment of infection, immunity and MODS. Similarly rigorous patient-oriented research methods will be applied to improve outcomes of high-priority emergency medical and surgical diseases, using the full facilities of the WUMS and its Department of Pediatrics. We have in place a structure in which bright, motivated young pediatricians will flourish in a protected environment and will emerge as leaders in this evolving subspecialty of pediatrics. We plan to enroll one new post-doctoral fellow per year for a 5-year period. The proposed duration of training for each fellow is 2 years. The program takes advantage of 25 established investigators who will serve as mentors. The long-term goals will be realized as its trainees contribute to the development of and leadership as pediatric emergency physician-scientists during the next two or more decades.