Human gut microbiome viewed across age and geography.
Human gut microbiome viewed across age and geography.
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DOI：
10.1038/nature11053
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发表时间：
2012-05-09
期刊：
影响因子：
64.8
通讯作者：
Gordon, Jeffrey I.
中科院分区：
文献类型：
--
作者：
Yatsunenko, Tanya;Rey, Federico E.;Manary, Mark J.;Trehan, Indi;Dominguez-Bello, Maria Gloria;Contreras, Monica;Magris, Magda;Hidalgo, Glida;Baldassano, Robert N.;Anokhin, Andrey P.;Heath, Andrew C.;Warner, Barbara;Reeder, Jens;Kuczynski, Justin;Caporaso, J. Gregory;Lozupone, Catherine A.;Lauber, Christian;Clemente, Jose Carlos;Knights, Dan;Knight, Rob;Gordon, Jeffrey I.
肠道微生物群落代表了人类遗传和代谢多样性的一个来源。为了研究从组成微生物谱系、编码的代谢功能、出生后发育阶段和环境暴露的角度来看，肠道微生物组在人群之间的差异，我们表征了从531名来自委内瑞拉亚马逊河流域的健康美洲印第安人、马拉维农村社区居民和美国大都市区居民的粪便样本中存在的细菌种类。以及110种微生物的基因含量。该队列包括婴儿、儿童、青少年和成人、父母和后代，并包括单卵和双卵双胞胎。在所有三个人群生命的前三年中，确定了肠道微生物组功能成熟的共同特征，包括与维生素生物合成和代谢相关的基因表达的年龄相关变化。与其他两个国家相比，居住在美国的个人在细菌种类组合和功能基因库方面存在显著差异。这些独特的特征在婴儿早期和成年期都很明显。此外，家庭成员之间粪便微生物组的相似性跨越文化。这些发现强调了在评估人类发育、营养需求、生理变化和西化影响时考虑微生物组的必要性。
Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ between human populations when viewed from the perspective of component microbial lineages, encoded metabolic functions, stage of postnatal development, and environmental exposures, we characterized bacterial species present in fecal samples obtained from 531 individuals representing healthy Amerindians from the Amazonas of Venezuela, residents of rural Malawian communities, and inhabitants of USA metropolitan areas, as well as the gene content of 110 of their microbiomes. This cohort encompassed infants, children, teenagers and adults, parents and offspring, and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the representation of genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial species assemblages and functional gene repertoires were noted between individuals residing in the USA compared to the other two countries. These distinctive features are evident in early infancy as well as adulthood. In addition, the similarity of fecal microbiomes among family members extends across cultures. These findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations, and the impact of Westernization.
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影响因子：
5.8
作者：
Kristiansson, Erik;Hugenholtz, Philip;Dalevi, Daniel
通讯作者：
Dalevi, Daniel
影响因子：
30.3
作者：
Martens EC;Chiang HC;Gordon JI
通讯作者：
Gordon JI
DOI：
10.1126/science.1198719
发表时间：
2011-05-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Muegge BD;Kuczynski J;Knights D;Clemente JC;González A;Fontana L;Henrissat B;Knight R;Gordon JI
通讯作者：
Gordon JI
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
9.3
作者：
Monsen, AUB;Refsum, H;Ueland, PM
通讯作者：
Ueland, PM