FOLIC ACID SUPPLEMENTATION & SEMEN QUALITY TRIAL (FASST)

补充叶酸

• 批准号: 9256375
• 负责人: CHARLES PETERSON
• 金额: $ 304.1万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-07 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9256375
• 关键词: Clinical; Couples; DNA; DNA Fragmentation; Diet; Embryo; Fertilization; Fertilization in Vitro; Folic Acid; Goals; Human Chorionic Gonadotropin; Incidence; Intervention; Intracytoplasmic Sperm Injections; Placebos; Pregnancy; Procedures; Public Health; Research; Seminal fluid; Supplementation; Treatment outcome; Zinc Sulfate; Zinc supplementation; cell motility; folic acid supplementation; implantation; improved; infertility treatment; men; sperm cell; sperm morphology

The overarching goal of this trial is to determine if an intervention comprising dietary folate and zinc supplementation improves semen quality and infertility treatment outcomes among couples undergoing infertility treatment. If efficacious and safe, such an intervention would have considerable public health impact and afford clinicians a simple and inexpensive treatment option for men with suboptimal semen quality. The following study objective underlie successful attainment of the overarching research goal.

这项试验的首要目标是确定包括膳食叶酸和锌补充剂的干预是否能改善接受不孕症治疗的夫妇的精液质量和不孕症治疗结果。如果有效且安全，这种干预将对公共卫生产生相当大的影响，并为精液质量欠佳的男性提供简单而廉价的治疗选择。以下研究目标是成功实现总体研究目标的基础。