ADMINISTRATIVE CORE

行政核心

• 批准号: 9150822
• 负责人: CAROL A WISE
• 金额: $ 1.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9150822
• 关键词: Adherence; Adolescent; Advisory Committees; Animals; Budgets; California; Caring; Child; Communication; Congenital Abnormality; Data; Development; Educational workshop; Electronics; Ensure; Ethics; Funding; Genomics; Goals; Guidelines; Human; IACUC; Idiopathic scoliosis; Institutional Review Boards; Knowledge; Lead; Manuscripts; Medical center; Modeling; Monitor; Musculoskeletal Diseases; National Institute of Child Health and Human Development; Outcome; Pathogenesis; Pediatric Hospitals; Persons; Policies; Preparation; Productivity; Publications; Quality Control; Regulation; Regulator Genes; Research; Research Personnel; San Francisco; Specific qualifier value; Structure; Texas; TimeLine; United States National Institutes of Health; Universities; Update; Washington; Work; Writing; Zebrafish; abstracting; base; data sharing; follow-up; gene discovery; human subject protection; innovation; medical schools; meetings; performance site; programs; success; symposium; tool development

Project Summary/Abstract (Admin Core) We have established an innovative Program entitled “Developmental Mechanisms of Human Idiopathic Scoliosis”. This program combines unbiased gene discovery in humans, modeling and gene discovery in zebrafish, and genomic analysis of gene regulatory sequences that will define the underlying causes of adolescent idiopathic scoliosis (AIS), the most common musculoskeletal disorder in children. Three research groups are leading these efforts. Project 1 “Human” focuses on AIS gene discovery and is led by Carol A. Wise, PD, PI, University of Texas Southwestern Medical Center and Texas Scottish Rite Hospital for Children. Project 2 “Zebrafish” is led by Lila Solnica-Krezel, Washington University School of Medicine St. Louis. Project 3 “Genomics” is led by Nadav Ahituv, University of California San Francisco. The Administrative Core will aid activities of the Program, which is already a working collaborative, and will be ultimately responsible for its execution and productivity. The Core will facilitate organization, communication, data flow, compliance, and productivity between the research groups. Specific responsibilities of the Core will be to ensure effective and frequent communication between component groups of the project, to establish and communicate with an Advisory Committee, to respond to advice from the committee, to ensure that funding is disbursed appropriately, to maintain compliance and oversee quality control, and to support high productivity. The Program Director Dr. Wise and an administrative assistant will oversee the administration of the Program. A primary activity of the Administrative Core will be to coordinate frequent, structured meetings between groups and the Advisory Committee as a forum for regular updates, to promote the exchange of ideas and data, and to keep the program on track by monitoring adherence to established timelines. The Core will organize an annual, dedicated face-to-face meeting of the Program components and Advisory Committee. The core will also coordinate meetings at conferences, notably the NICHD Birth Defects workshop and other professional meetings. Importantly, the Administrative core will summarize key conclusions and critical follow-up steps that emerge from all meetings, whether electronic or in person, for the Program. Otherwise the Administrative Core will be responsible for regularly monitoring budgets, compliance with ethical guidelines, compliance with institutional and federal requirements (e.g. institutional review boards, institutional animal care and use committees), and compliance with data-sharing policies. Finally, the Core will facilitate the preparation and submission of manuscripts, ensuring fairness and consistency with NIH public access policies. In these ways the Core will promote synergistic interaction within the Program and hasten the goal to decipher the pathogenesis of AIS. 1

项目摘要/摘要（管理核心） 我们建立了一个创新项目，题为“人类特发性痴呆的发展机制” 脊柱侧凸”。该计划结合了人类的公正基因发现、建模和基因发现 斑马鱼和基因调控序列的基因组分析将确定其根本原因 青少年特发性脊柱侧凸（AIS），儿童最常见的肌肉骨骼疾病。三研究 一些团体正在领导这些努力。项目 1“人类”专注于 AIS 基因发现，由 Carol A. Wise，PD、PI，德克萨斯大学西南医学中心和德克萨斯苏格兰儿童医院。 项目 2“斑马鱼”由圣路易斯华盛顿大学医学院的 Lila Solnica-Krezel 领导。 项目 3“基因组学”由加州大学旧金山分校的 Nadav Ahituv 领导。行政核心 将协助该计划的活动，该计划已经是一个工作协作项目，并将最终负责 它的执行力和生产力。核心将促进组织、通信、数据流、合规性和 研究小组之间的生产力。核心的具体职责是确保有效和 项目各组成部分之间的频繁沟通，建立并沟通 咨询委员会，回应委员会的建议，确保资金拨付 适当地保持合规性和监督质量控制，并支持高生产率。这 项目总监怀斯博士和一名行政助理将监督该项目的管理。一个 行政核心的主要活动是协调各小组之间频繁的、结构化的会议 和咨询委员会作为定期更新的论坛，以促进思想和数据的交流，以及 通过监督对既定时间表的遵守情况来确保计划步入正轨。核心将组织一次 计划组成部分和咨询委员会每年举行专门的面对面会议。核心将 还协调会议上的会议，特别是 NICHD 出生缺陷研讨会和其他专业会议 会议。重要的是，行政核心将总结关键结论和关键后续步骤， 该计划的所有会议，无论是电子会议还是现场会议。否则行政核心 将负责定期监控预算、遵守道德准则、遵守 机构和联邦要求（例如机构审查委员会、机构动物护理和使用 委员会），以及遵守数据共享政策。最后，核心将促进准备工作和 提交稿件，确保公平性并与 NIH 公共获取政策保持一致。通过这些方式 核心将促进计划内的协同互动，并加速实现破译 AIS 的发病机制。 1