ADMINISTRATIVE CORE

项目摘要/摘要（管理核心） 我们已经建立了一个创新的项目，题为“人类特发性 脊柱侧凸”。该计划结合了人类无偏见的基因发现，建模和基因发现， 斑马鱼，基因调控序列的基因组分析，将确定的根本原因， 青少年特发性脊柱侧凸（AIS）是儿童中最常见的肌肉骨骼疾病。三个研究 这些团体正在领导这些努力。项目1“人类”专注于AIS基因发现，由Carol A. 怀斯，PD，PI，得克萨斯大学西南医学中心和得克萨斯苏格兰儿童医院。 项目2“斑马鱼”由华盛顿大学圣路易斯医学院的Lila Solnica-Krezel领导。 项目3“基因组学”由加州旧金山弗朗西斯科的Nadav Ahituv领导。行政核心 将援助该计划的活动，这已经是一个工作协作，并将最终负责 执行力和生产力。核心将促进组织、通信、数据流、合规性， 研究组之间的生产力。核心小组的具体责任是确保有效和 项目各组成部分之间的频繁沟通，以建立和沟通， 咨询委员会，对委员会的咨询意见作出回应，以确保资金得到支付 适当地，以保持合规性和监督质量控制，并支持高生产力。的 项目主任怀斯博士和一名行政助理将监督项目的管理。一 行政核心的主要活动是协调小组之间频繁的、有组织的会议 和咨询委员会作为定期更新的论坛，以促进思想和数据的交流， 通过监控对既定时间表的遵守情况，使项目保持在正轨上。核心将组织一个 年度，专门面对面的会议，该计划的组成部分和咨询委员会。芯会 还协调会议，特别是NICHD出生缺陷研讨会和其他专业会议。 会议.重要的是，行政核心将总结关键结论和关键后续步骤， 出现在所有会议上，无论是电子或亲自，为计划。否则，行政核心 将负责定期监测预算，遵守道德准则，遵守 机构和联邦要求（如机构审查委员会、机构动物护理和使用 （三）遵守数据共享政策。最后，核心将促进编写工作， 提交手稿，确保与NIH公共访问政策的公平性和一致性。以这些方式 “核心”计划将促进“计划”内的协同互动，加速实现破译 AIS的发病机制。 1

Project Summary/Abstract (Admin Core) We have established an innovative Program entitled “Developmental Mechanisms of Human Idiopathic Scoliosis”. This program combines unbiased gene discovery in humans, modeling and gene discovery in zebrafish, and genomic analysis of gene regulatory sequences that will define the underlying causes of adolescent idiopathic scoliosis (AIS), the most common musculoskeletal disorder in children. Three research groups are leading these efforts. Project 1 “Human” focuses on AIS gene discovery and is led by Carol A. Wise, PD, PI, University of Texas Southwestern Medical Center and Texas Scottish Rite Hospital for Children. Project 2 “Zebrafish” is led by Lila Solnica-Krezel, Washington University School of Medicine St. Louis. Project 3 “Genomics” is led by Nadav Ahituv, University of California San Francisco. The Administrative Core will aid activities of the Program, which is already a working collaborative, and will be ultimately responsible for its execution and productivity. The Core will facilitate organization, communication, data flow, compliance, and productivity between the research groups. Specific responsibilities of the Core will be to ensure effective and frequent communication between component groups of the project, to establish and communicate with an Advisory Committee, to respond to advice from the committee, to ensure that funding is disbursed appropriately, to maintain compliance and oversee quality control, and to support high productivity. The Program Director Dr. Wise and an administrative assistant will oversee the administration of the Program. A primary activity of the Administrative Core will be to coordinate frequent, structured meetings between groups and the Advisory Committee as a forum for regular updates, to promote the exchange of ideas and data, and to keep the program on track by monitoring adherence to established timelines. The Core will organize an annual, dedicated face-to-face meeting of the Program components and Advisory Committee. The core will also coordinate meetings at conferences, notably the NICHD Birth Defects workshop and other professional meetings. Importantly, the Administrative core will summarize key conclusions and critical follow-up steps that emerge from all meetings, whether electronic or in person, for the Program. Otherwise the Administrative Core will be responsible for regularly monitoring budgets, compliance with ethical guidelines, compliance with institutional and federal requirements (e.g. institutional review boards, institutional animal care and use committees), and compliance with data-sharing policies. Finally, the Core will facilitate the preparation and submission of manuscripts, ensuring fairness and consistency with NIH public access policies. In these ways the Core will promote synergistic interaction within the Program and hasten the goal to decipher the pathogenesis of AIS. 1