Aging, Metabolism, Pathogenesis, Stress, and Small RNAs

衰老、新陈代谢、发病机制、压力和小 RNA

• 批准号: 9192538
• 负责人: Meng Carla Wang
• 金额: $ 4.5万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9192538
• 关键词: Aging; Aging-Related Process; Biological; Biological Process; Biology of Aging; Caenorhabditis elegans; Chronic Disease; Collaborations; Communication; Communities; Complex; Data; Degenerative Disorder; Discipline; Elderly; Environment; Epigenetic Process; Faculty; Feedback; Fostering; Funding; Health; Homeostasis; Incidence; Longevity; Metabolic; Metabolism; Microbe; Molecular; Natural Immunity; Nutrient; Older Population; Oral; Pathogenesis; Physiological; Postdoctoral Fellow; Public Health; Regulation; Request for Applications; Research; Research Personnel; Scientist; Signal Transduction; Site; Small RNA; Staging; Stress; Stress Response Signaling; Students; Therapeutic; Universities; Wisconsin; abstracting; age related; aged; base; biological adaptation to stress; career; collaborative environment; experience; forging; graduate student; healthy aging; lectures; meetings; nutrition related genetics; posters; rapid growth; reproductive; success; symposium

Project Summary The number of elderly people (aged 65 and older) in the U.S. will be more than doubled, from 40.3 million in 2010 to 88.5 million in 2050. This rapid growth of the older population dramatically increases the incidence of chronic and degenerative diseases, and presents a grand challenge for public health. To tackle this challenge, success from C. elegans research makes significant contribution. C. elegans is a proven workhorse of aging research, and new discoveries in C. elegans have greatly accelerated the advance of the field of aging biology. This conference on Aging, Metabolism, Pathogenesis, Stress, and Small RNAs is the only topic meeting on aging in the C. elegans community and will bring together scientists from numerous disciplines for the purpose of defining, describing, and analyzing critical scientific problems and recent advances in aging biology and its related fields. Since the inauguration of this conference in 2010, the aging biology field has grown dramatically, which is reflected in the enthusiasm for this conference. The rapid growth of the field is attracting particularly young scientists at the start of their career. The conference has a strong tradition providing a forum for young scientists, providing an opportunity to present data and engage in scientific discussion across seniority levels. For a complex biological problem like aging, advances in understanding its underlying molecular mechanisms require scientists from a number of backgrounds and scientific disciplines. Due to their different background, many researchers have not previously attended the same conferences. Based on our experience, we are confident that the small conference format and secluded conference site will foster an intimate and interactive environment in which junior investigators, including graduate students, postdoctoral fellows, and junior faculty, will have ample opportunity to interact with more senior, established investigators. This application requests funding to support the participation of invited speakers, session chairs (junior investigators), graduate students and postdoctoral fellows at the conference to be held July 21-24, 2015 at University of Wisconsin, Madison. The format will include one Keynote lecture, six sessions of talks with invited speakers, and in each session additional short talks to be selected from submitted abstracts. The session topics include: 1) Reproductive Aging and Signaling, 2) Environments and Nutrients, 3) Cellular Metabolism, 4) RNAs and Epigenetics, 5) Microbe-Host Interaction, and 6) Stress Response and Signaling. Two poster sessions, as well as the short talks to be selected from abstracts, will allow additional investigators, including graduate students and postdoctoral fellows, to present their research. In addition, two “Meet the experts” sessions will further increase the number of opportunities for junior researchers to connect to established PIs in this field.

项目摘要 美国老年人(65岁及以上)的数量将从2019年的4030万人增加一倍以上。 2010年增加到2050年的8850万。老年人口的快速增长极大地增加了发病率 这是慢性和退化性疾病的一个重要组成部分，对公共卫生提出了重大挑战。来解决这个问题 挑战，线虫研究的成功做出了重大贡献。线虫是一种经过验证的 衰老研究的主力，以及线虫的新发现，大大加快了衰老研究的进展 衰老生物学领域。这次关于衰老、新陈代谢、发病机制、应激和小的会议 RNAs是线虫群落中唯一关于衰老的主题会议，将把来自 众多学科，用于定义、描述和分析关键科学问题 衰老生物学及其相关领域的最新进展。自2010年本届大会开幕以来， 老龄化生物学领域大幅增长，这反映在对这次会议的热情上。这个 该领域的快速发展尤其吸引了刚开始职业生涯的年轻科学家。这次会议 有一个为年轻科学家提供论坛的强大传统，提供了一个展示数据和 参与不同资历级别的科学讨论。对于像衰老这样的复杂生物问题， 在了解其潜在的分子机制方面的进展需要来自许多科学家的 背景和科学学科。由于他们的背景不同，许多研究人员没有 此前曾参加过同样的会议。根据我们的经验，我们有信心小的 会议形式和隐蔽的会议地点将营造一个亲密和互动的环境，在其中 初级研究员，包括研究生、博士后研究员和初级教员，将有足够的 有机会与更资深、更成熟的调查人员互动。 这项申请申请资金，以支持受邀发言者、会议主席(初级 研究人员)、研究生和博士后研究员出席会议，会议将于2015年7月21日至24日在 威斯康星大学麦迪逊分校。形式将包括一次主旨演讲，六次与 邀请发言者，并在每一次会议中从提交的摘要中挑选额外的简短演讲。这个 会议主题包括：1)生殖衰老和信号，2)环境和营养，3)细胞 代谢，4)RNA和表观遗传学，5)微生物-宿主相互作用，6)胁迫反应和信号。 两个海报会议，以及从摘要中挑选出来的简短演讲，将允许额外的 研究人员，包括研究生和博士后研究员，介绍他们的研究。此外, 两次与专家见面的会议将进一步增加初级研究人员的机会 连接到此字段中已建立的PI。