Aging, Metabolism, Pathogenesis, Stress, and Small RNAs

项目摘要 美国老年人（65岁及以上）的数量将从2010年的4030万增加一倍多。 2010年至2050年的8850万。老年人口的快速增长大大增加了发病率 慢性和退行性疾病，并提出了一个巨大的挑战，公共卫生。解决这个 挑战，成功来自C。研究作出了重大贡献。C. elegans是一种被证明 衰老研究的主力，以及C.秀丽线虫大大加速了 衰老生物学领域。这次会议上老化，代谢，发病机制，压力，和小 RNA是C. elegans社区，并将汇集科学家从 许多学科的目的是定义，描述和分析关键的科学问题， 衰老生物学及其相关领域的最新进展。自2010年该会议开幕以来， 衰老生物学领域发展迅速，这反映在对这次会议的热情上。的 这一领域的迅速发展尤其吸引着刚开始职业生涯的年轻科学家。会议 有着为年轻科学家提供论坛的悠久传统，提供了展示数据的机会， 参与跨资历级别的科学讨论。对于像衰老这样复杂的生物学问题， 要了解其潜在的分子机制，需要来自许多国家的科学家， 背景和科学学科。由于他们的背景不同，许多研究者没有 以前参加过同样的会议。根据我们的经验，我们相信， 会议形式和隐蔽的会议场地将营造一个亲密和互动的环境， 初级研究人员，包括研究生，博士后研究员和初级教师，将有足够的 有机会与更资深、更成熟的调查人员互动。 本申请要求提供资金，以支持受邀演讲者、会议主席（初级 研究人员），研究生和博士后研究员在会议将于2015年7月21日至24日在 威斯康星州，麦迪逊大学。形式将包括一个主题演讲，六个会议的会谈， 邀请演讲者，并在每次会议上从提交的摘要中选出额外的简短演讲。的 会议主题包括：1）生殖老化和信号，2）环境和营养，3）细胞 代谢，4）RNA和表观遗传学，5）微生物-宿主相互作用，以及6）应激反应和信号传导。 两个海报会议，以及从摘要中选择的简短演讲，将允许额外的 研究人员，包括研究生和博士后研究员，介绍他们的研究。此外，本发明还提供了一种方法， 两个“会见专家”会议将进一步增加初级研究人员的机会， 连接到该字段中已建立的PI。

Project Summary The number of elderly people (aged 65 and older) in the U.S. will be more than doubled, from 40.3 million in 2010 to 88.5 million in 2050. This rapid growth of the older population dramatically increases the incidence of chronic and degenerative diseases, and presents a grand challenge for public health. To tackle this challenge, success from C. elegans research makes significant contribution. C. elegans is a proven workhorse of aging research, and new discoveries in C. elegans have greatly accelerated the advance of the field of aging biology. This conference on Aging, Metabolism, Pathogenesis, Stress, and Small RNAs is the only topic meeting on aging in the C. elegans community and will bring together scientists from numerous disciplines for the purpose of defining, describing, and analyzing critical scientific problems and recent advances in aging biology and its related fields. Since the inauguration of this conference in 2010, the aging biology field has grown dramatically, which is reflected in the enthusiasm for this conference. The rapid growth of the field is attracting particularly young scientists at the start of their career. The conference has a strong tradition providing a forum for young scientists, providing an opportunity to present data and engage in scientific discussion across seniority levels. For a complex biological problem like aging, advances in understanding its underlying molecular mechanisms require scientists from a number of backgrounds and scientific disciplines. Due to their different background, many researchers have not previously attended the same conferences. Based on our experience, we are confident that the small conference format and secluded conference site will foster an intimate and interactive environment in which junior investigators, including graduate students, postdoctoral fellows, and junior faculty, will have ample opportunity to interact with more senior, established investigators. This application requests funding to support the participation of invited speakers, session chairs (junior investigators), graduate students and postdoctoral fellows at the conference to be held July 21-24, 2015 at University of Wisconsin, Madison. The format will include one Keynote lecture, six sessions of talks with invited speakers, and in each session additional short talks to be selected from submitted abstracts. The session topics include: 1) Reproductive Aging and Signaling, 2) Environments and Nutrients, 3) Cellular Metabolism, 4) RNAs and Epigenetics, 5) Microbe-Host Interaction, and 6) Stress Response and Signaling. Two poster sessions, as well as the short talks to be selected from abstracts, will allow additional investigators, including graduate students and postdoctoral fellows, to present their research. In addition, two “Meet the experts” sessions will further increase the number of opportunities for junior researchers to connect to established PIs in this field.