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CCL19 Regulation of the Secondary Immune Response

CCL19 二次免疫反应的调节

基本信息

批准号：
9096831
负责人：
CHARLOTTE M VINES
金额：
$ 37.75万
依托单位：
UNIVERSITY OF TEXAS EL PASO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9096831
关键词：
Affect Affinity Animal Diseases Animals Antibodies Antibody Affinity Antibody Formation Antigen-Presenting Cells Antigens Autoantigens Autoimmune Diseases Autoimmunity B-Lymphocytes Binding Biological Assay CC chemokine receptor 7 CCL19 gene CCL21 gene CD4 Positive T Lymphocytes Cells Dendritic Cells Drug or chemical Tissue Distribution Event Exposure to Extracellular Signal Regulated Kinases Female Fluorescence Future Generations Goals Health Helper-Inducer T-Lymphocyte Human IgG1 Immune Immune response Immunization Immunoglobulin Class Switching Immunoglobulin G Immunologic Memory In Vitro Invaded Knowledge Lead Learning Leukocytes Ligand Binding Ligands Ligation Lymphocyte Major Histocompatibility Complex Mediating Medical Molecular Mus Mutation Analysis Peripheral Persons Play Population Precipitation Production Regulation Research Design Role Scanning Secondary Immunization Serum Signal Transduction Site Structure of germinal center of lymph node Surface T memory cell T-Lymphocyte Testing Time Tissues Up-Regulation Vaccination Vaccine Adjuvant Wild Type Mouse Work adaptive immunity base beta-Chemokines cell motility cell type chemokine chemokine receptor cytokine differential expression gamma-Chemokines immunogenic improved in vivo insight lymph nodes male migration pathogen prevent residence response tool

项目摘要

DESCRIPTION (provided by applicant): When a host (person or animal) is exposed to a substance that causes an immune response, under certain circumstances the body generates antibodies. Although the generation of protective antibodies is the purpose of vaccinations, there is very little understood about the role of chemokines in controlling the numbers and types of antibodies that are produced during the secondary immune response. C-C chemokine receptor 7 is a chemokine receptor that regulates the levels of antibodies made. The goal of our studies is to learn how a host uses C-C chemokine receptor 7 to regulate the levels of antibodies that are made during a secondary immune response. This is important since antibodies provide protection to the host when he/she is exposed to the same substance during a secondary immune response. We hypothesize that loss of CCR7 or signaling to downstream effectors such as ERK5 will disrupt targeting of effector memory T cells leading to increased antibody production following the second exposure to an antigen. With the knowledge we gain we will determine if promoting CCR7 signaling during vaccination against a specific self-antigen, and in the near future, can be used to prevent excessive production of antibodies observed during autoimmune disease.

描述(申请人提供)：当宿主(人或动物)接触到一种引起免疫反应的物质时，在某些情况下，身体会产生抗体。虽然产生保护性抗体是疫苗接种的目的，但人们对趋化因子在控制二次免疫反应期间产生的抗体的数量和类型方面的作用知之甚少。C-C趋化因子受体7是一种趋化因子受体，调节产生的抗体水平。我们研究的目标是了解宿主如何使用C-C趋化因子受体7来调节二次免疫反应期间产生的抗体水平。这一点很重要，因为在二次免疫反应期间，当宿主暴露在同一物质中时，抗体为宿主提供保护。我们假设，CCR7的丢失或向下游效应器(如ERK5)发出的信号将扰乱效应器记忆T细胞的靶向，导致第二次接触抗原后抗体产生增加。随着我们获得的知识，我们将确定在针对特定自身抗原的疫苗接种期间促进CCR7信号传递是否可以用于防止在自身免疫性疾病期间观察到的抗体的过度产生。