Perturbation of Craniofacial Morphogenesis, Healing, and Regeneration by E-cigarette Aerosol Mixtures
电子烟气溶胶混合物对颅面形态发生、愈合和再生的干扰
基本信息
- 批准号:9208724
- 负责人:
- 金额:$ 22.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-03-07 至 2018-02-28
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdultAdvertisingAerosolsAffectAgeApoptosisApoptoticAreaBiochemicalBiologicalBone TissueBurn injuryCellsChronicCigaretteCoculture TechniquesComplementConsumptionCountryDentalDeveloped CountriesDeveloping CountriesDevelopmentDevicesElectronic cigaretteElectronicsEmbryoEngineeringEnzyme-Linked Immunosorbent AssayExposure toFlavoringGoalsGrowthHealedHealthHomeostasisImmuneImmunohistochemistryImplantIn VitroInflammationInflammation MediatorsInflammatoryInjection of therapeutic agentLiquid substanceMarketingMeasuresMethodsModelingMolecularMorphogenesisMorphologyMothersMusNatural regenerationNewborn InfantNicotineOperative Surgical ProceduresOral cavityPhysiological ProcessesPopulationPregnancyPublic HealthRegulationRiskSalesSeriesSmokeSmokerSmokingStructureSystemTissue EngineeringTissuesTobaccoTobacco smokingTobacco useTooth ExtractionToxic effectWound HealingX-Ray Computed TomographyXenopusXenopus laevisaerosolizedcell typechild bearingcigarette smokingcraniofacialcraniofacial developmentcytotoxichealingin uteroin vitro Modelin vivoin vivo Modelin vivo regenerationmaternal cigarette smokingnoveloffspringorofacialorofacial developmentregenerativeregenerative therapyscaffold
项目摘要
DESCRIPTION (provided by applicant): More than 1.3 billion people worldwide use tobacco products. Tobacco products are tightly regulated in most developed countries, and with these regulations, use has decreased. However, tobacco consumption is increasing globally due to increased consumption in developing nations. E-cigarettes are battery-powered nicotine delivery systems advertised as "healthier" than cigarettes that are gaining in popularity globally. By 2014,
more than 466 brands existed with more than 7764 uniquely flavored nicotine solutions (e-liquids). While some countries have imposed restrictions sales of e-cigarettes, these devices are mostly unregulated. While the harmful effects of cigarette smoking in the orofacial region are recognized, little is known about the effects of aerosolized e-liquids. The goal of this applicatio is to unravel the effects of e-cigarette aerosol mixtures using a multi-system approach with robust in vitro and in vivo models to identify the most susceptible cell types and tissues, as well
as the effects of these aerosol mixtures in the development, healing, and regeneration of craniofacial structures. Using cells from orofacial tissues as in vitro model, we will conduct biological, biochemical, and molecular interrogations to characterize the cytotoxic, proliferative,
apoptotic, and inflammatory effects of aerosol mixtures. Additionally, we will use our novel Xenopus laevis model to elucidate the effects of e-cigarette aerosols in craniofacial development. These development studies will be complemented by our chronic exposure model, in which mice will be exposed to e-cigarette aerosols during pregnancy and the effects on their offspring's orofacial development studied. Our comprehensive approach will also investigate the effects of e-cigarette aerosols in our models of wound healing and regeneration, including common craniofacial surgical procedures like tooth extractions and dental implants, as well as more recent methods like bone tissue engineering. This approach will result in a detailed understanding of the effects of e- cigarette aerosol mixtures on the homeostasis, development, wound healing, and regeneration of craniofacial tissues.
描述(由申请人提供):全世界有超过 13 亿人使用烟草制品。烟草产品在大多数发达国家都受到严格监管,随着这些规定的实施,烟草产品的使用量有所减少。然而,由于发展中国家消费量的增加,全球烟草消费量正在增加。电子烟是电池供电的尼古丁输送系统,被宣传为比香烟“更健康”,在全球越来越受欢迎。到2014年,
超过 466 个品牌,超过 7764 种独特口味的尼古丁溶液(电子烟油)。尽管一些国家对电子烟的销售实施了限制,但这些设备大多不受监管。虽然人们认识到吸烟对口面部区域的有害影响,但人们对雾化电子烟液的影响却知之甚少。该应用的目标是使用多系统方法和强大的体外和体内模型来揭示电子烟气溶胶混合物的影响,以确定最敏感的细胞类型和组织。
这些气溶胶混合物对颅面结构的发育、愈合和再生的影响。使用来自口面部组织的细胞作为体外模型,我们将进行生物学、生化和分子研究,以表征细胞毒性、增殖性、
气溶胶混合物的细胞凋亡和炎症作用。此外,我们将使用我们的新型非洲爪蟾模型来阐明电子烟气溶胶对颅面发育的影响。这些发育研究将得到我们的慢性暴露模型的补充,在该模型中,小鼠将在怀孕期间暴露于电子烟气溶胶,并研究对其后代口面部发育的影响。我们的综合方法还将研究电子烟气溶胶在伤口愈合和再生模型中的影响,包括拔牙和种植牙等常见颅面外科手术,以及骨组织工程等最新方法。这种方法将有助于详细了解电子烟气溶胶混合物对颅面组织的稳态、发育、伤口愈合和再生的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Amanda Jane Dickinson其他文献
Amanda Jane Dickinson的其他文献
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{{ truncateString('Amanda Jane Dickinson', 18)}}的其他基金
DYRK1A interaction network in development and disease
发育和疾病中的 DYRK1A 相互作用网络
- 批准号:
10373183 - 财政年份:2022
- 资助金额:
$ 22.34万 - 项目类别:
Perturbation of Craniofacial Morphogenesis, Healing, and Regeneration by E-cigarette Aerosol Mixtures
电子烟气溶胶混合物对颅面形态发生、愈合和再生的干扰
- 批准号:
9237261 - 财政年份:2016
- 资助金额:
$ 22.34万 - 项目类别:
JNK regulation of desmosomes in development.
JNK 对发育过程中桥粒的调节。
- 批准号:
9052712 - 财政年份:2014
- 资助金额:
$ 22.34万 - 项目类别:
JNK regulation of desmosomes in development.
JNK 对发育过程中桥粒的调节。
- 批准号:
8769474 - 财政年份:2014
- 资助金额:
$ 22.34万 - 项目类别:
Using Frog Faces to Better Understand Clefts in the Primary Palate
利用青蛙脸更好地了解初级腭裂
- 批准号:
8759433 - 财政年份:2014
- 资助金额:
$ 22.34万 - 项目类别:
JNK regulation of desmosomes in development.
JNK 对发育过程中桥粒的调节。
- 批准号:
8870297 - 财政年份:2014
- 资助金额:
$ 22.34万 - 项目类别:
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