Pathways to improved, sustainable morbidity control and prevention of schistosomiasis in the People's Republic of China.

中华人民共和国改善、可持续的血吸虫病发病控制和预防的途径。

• 批准号: nhmrc : 290238
• 负责人: Prof Don Mcmanus
• 金额: $ 88.67万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathways-improved-sustainable-republic-china/76727
• 关键词: Pathways; improved; sustainable; morbidity; control

600 million Chinese are infected with parasites. One of the most important of these is the Asia or Oriental human bloodfluke, Schistosoma japonicum. It causes schistosomiasis (Bilharzia), a very serious and debilitating disease and a major health problem for more than 40 million Chinese living in Southern China. Infection occurs when people make contact with water contaminated by microscopically small cercariae larvae that are released from freshwater snails. As well as humans, Schistosoma japonicum infects a number of other mammals, such as water buffaloes, which complicates control efforts. Current control is based on treatment with the drug parziquantel. Vaccines in combination with other control methods, including the use of new drugs, are needed to make elimination of the disease possible. This new program of research has a very strong emphasis on mutual research training and scientific interaction that will: determine whether another drug, artemether, can be used as an aid in control; increase our understanding of the immunological and genetic processes involved in the development of the disease of schistosomiasis; determine the importance of buffalo infections in maintaining human schistosomiasis transmission; undertake genomics and post-genomics research on existing and new discovered S. japonicum molecules that are candidates as new vaccines and diagnostics; and develop a mathematical model that can predict the optimum methods for the sustained control of schistosomiasis in China.

6亿中国人感染寄生虫。其中最重要的是亚洲或东方人血吸虫，日本血吸虫。它导致血吸虫病（血吸虫病），这是一种非常严重和使人衰弱的疾病，是生活在中国南方的4000多万中国人的主要健康问题。当人们接触到被淡水蜗牛释放出来的显微镜下可见的小尾蚴幼虫污染的水时，就会发生感染。除了人类，日本血吸虫还感染了许多其他哺乳动物，如水牛，这使得控制工作变得复杂。目前的控制是基于药物parziquantel的治疗。需要将疫苗与其他控制方法结合起来，包括使用新药，才有可能消灭这种疾病。这一新的研究方案非常强调相互研究、培训和科学互动，以便：确定另一种药物蒿甲醚是否可用于辅助控制;增加我们对血吸虫病发展所涉及的免疫和遗传过程的了解;确定布法罗感染在维持人类血吸虫病传播方面的重要性;对现有的和新发现的S.日本血吸虫的分子，作为新的疫苗和诊断的候选人，并开发一个数学模型，可以预测在中国血吸虫病的持续控制的最佳方法。