Pharyngeal wall folding: role in upper airway collapsibility

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In obstructive sleep apnoea (OSA) the throat closes during sleep. In order for the throat to close the surface of the throat has to fold. Mathematical models predict that the more folds present, the more stable a structure will be. This research will examine how folding of the airway surface of the throat is achieved in subjects with and without OSA. It will also develop ways of changing the folding patterns using bench, animal and human studies. This will result in new treatments for OSA.