Pharmacology of Potential Anti-Tumour Agents: Iron and Copper Chelators of the ApT, BpT and DpT Classes

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Cancer cells take up more of the essential nutrients copper and iron than normal cells. Increased metabolism of these metals is linked to tumour growth progression. Our laboratory has developed compounds that bind these metals in tumours. Our studies suggest our novel compounds display a novel tumour targeting strategy which may explain their ability to also overcome drug resistance. This unique mechanism of action is crucial to understand for the development of novel anti-cancer agents.