Slowing progression of Alzheimer’s disease by modulating the kynurenine pathway
Slowing progression of Alzheimer’s disease by modulating the kynurenine pathway
批准号:
nhmrc : 1128849
负责人:
Dr David Lovejoy
金额:
$39.51万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Chronic inflammation in the brain in known to be a factor in the progression of Alzheimer's disease. We are exploring if blocking a particular enzyme in a biochemical pathway involved in inflammation, can improve symptoms, or slow progression, of the disease in animal models of AD. If results are as expected, our proposal has the potential to generate a new a therapy for AD.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Pharmacology of Potential Anti-Tumour Agents: Iron and Copper Chelators of the ApT, BpT and DpT Classes
-
批准号:nhmrc : 1021607
-
项目类别:Project Grants
-
资助金额:$43.15万
-
财政年份:2012
-
负责人:Dr David Lovejoy
-
依托单位:
Pre-clinical Development of a Novel Second Generation Chemotherapeutic for Cancer Therapy
-
批准号:nhmrc : 1038660
-
项目类别:Development Grants
-
资助金额:$39.0万
-
财政年份:2012
-
负责人:Dr David Lovejoy
-
依托单位:
Investigating the Cellular Response to Iron-Depletion: The Trilogy of ASK1, Thioredoxin and Ribonucleotide Reductase
-
批准号:nhmrc : 1021601
-
项目类别:Project Grants
-
资助金额:$36.85万
-
财政年份:2012
-
负责人:Dr David Lovejoy
-
依托单位:
Toxicological and pre-clinical assessment of the anti-cancer compound Bp4eT
-
批准号:nhmrc : 571379
-
项目类别:NHMRC Development Grants
-
资助金额:$13.26万
-
财政年份:2009
-
负责人:Dr David Lovejoy
-
依托单位:
Examination of the Molecular Pharmacology of Anthracyclines Induced via their Interaction with Iron
-
批准号:nhmrc : 457310
-
项目类别:NHMRC Project Grants
-
资助金额:$41.24万
-
财政年份:2007
-
负责人:Dr David Lovejoy
-
依托单位:
国内基金
海外基金
PRNP调控巨噬细胞M2极化并减弱吞噬功能促进子宫内膜异位症进展的机制研究
-
批准号:82371651
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:赵栋
-
依托单位:
紧密连接蛋白PARD3下调介导黏膜上皮屏障破坏激活STAT3/SNAI2通路促进口腔白斑病形成及进展的机制研究
-
批准号:82370954
-
项目类别:面上项目
-
资助金额:47.00万元
-
批准年份:2023
-
负责人:沈雪敏
-
依托单位:
犬尿氨酸酶KYNU参与非酒精性脂肪肝进展为肝纤维化的作用和机制研究
-
批准号:82370874
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:刘才智
-
依托单位: