Phase III Trial of Radical Chemo-radiation Vs Radiation alone in the management of localised Bladder TCC.

根治性化疗与单纯放疗治疗局部膀胱 TCC 的 III 期试验。

• 批准号: nhmrc : 243100
• 负责人: A/Pr Elaine Beller
• 金额: $ 12.99万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/phase-iii-trial-bladder-tcc/78246
• 关键词: Phase; III; Trial; Radical; Chemo

This trial aims to see if the combination of Chemotherapy and Radiation treatment is indeed superior in eradicating the tumor and preserving the Bladder in a greater number of patients as compared to Radiation treatment alone. If the final results from this study do show chemoradiotherapy to be significantly superior to radiation alone, without an increase in morbidity ( especially long term side effects ) , this may lay the platform for a greater proportion of patients with localised bladder cancer, being in the first instance considered for this organ( bladder) preserving approach something which has become a reality at a number of other sites of cancer with the use of multimodality treatment.

这项试验旨在观察在更多的患者中，联合化疗和放射治疗是否真的比单纯放射治疗在根除肿瘤和保留膀胱方面更好。如果这项研究的最终结果确实显示放化疗明显优于单纯放射治疗，且发病率(特别是长期副作用)没有增加，这可能为更大比例的局限性膀胱癌患者奠定基础，首次考虑采用这种保留器官(膀胱)的方法，随着多模式治疗的使用，这种方法在其他一些癌症部位已经成为现实。