Polarity regulation in T cells: Mechanisms and consequences.

T 细胞的极性调节：机制和后果。

• 批准号: nhmrc : 559302
• 负责人: Prof Min Gu
• 金额: $ 36.17万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/polarity-regulation-t-mechanisms-consequences/98677
• 关键词: Polarity; regulation; cells; Mechanisms; consequences.

Advances in our understanding of how the immune system works have led to many breakthroughs in healthcare, including organ transplantation, management of autoimmune diseases and immunodeficiencies such as AIDS. To improve these treatments, we need a better understanding of how the immune system is controlled. This proposal explores the mechanisms by which immune cell signalling is regulated by spatial compartmentalisation within the cell.

我们对免疫系统如何工作的理解的进步导致了医疗保健的许多突破，包括器官移植，自身免疫性疾病和免疫缺陷（如艾滋病）的管理。为了改善这些治疗方法，我们需要更好地了解免疫系统是如何控制的。该提案探讨了免疫细胞信号传导通过细胞内的空间区室化来调节的机制。