Characterizing the regulators of mitochondrial biogenesis in Arabidopsis thaliana

拟南芥线粒体生物发生调节因子的表征

• 批准号: FT130100112
• 负责人: A/Prof Monika Murcha
• 金额: $ 50.48万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-02-17 至 2018-05-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100112
• 关键词: Characterizing; regulators; mitochondrial; biogenesis; Arabidopsis

The overall aim of this project is to identify and characterise the underlying regulatory factors that control mitochondrial mass and number in plants. The project will exploit a regulatory mechanism that links the mitochondrial import machinery and the respiratory chain. Utilising both forward and reverse genetic approaches, the abundances of protein import translocases will be altered and the changes to mitochondrial biogenesis will be investigated. This will identify regulatory factors, which can be manipulated and used to alter mitochondrial number and activity.

该项目的总体目标是确定和表征控制植物线粒体质量和数量的潜在调控因素。该项目将利用一种连接线粒体输入机制和呼吸链的调节机制。利用正向和反向遗传方法，蛋白质输入转位酶的丰度将被改变，并且线粒体生物发生的变化将被研究。这将确定可操纵并用于改变线粒体数量和活性的调节因子。