Pre-clinica evaluation of a novel HIV-1 vaccine statrgy

新型 HIV-1 疫苗策略的临床前评估

• 批准号: nhmrc : 1093532
• 负责人: A/Pr Charani Ranasinghe
• 金额: $ 35.24万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pre-clinica-evaluation-vaccine-statrgy/519440
• 关键词: Pre; clinica; evaluation; novel; HIV

Recently, we have designed two mucosal HIV vaccine strategies that temporary block hormone-like molecules IL-4/IL-13 at the vaccination site inducing excellent antibody and killer T cell immunity with protective efficacy in small animals. This project aims to evaluate the safety and efficacy of these novel HIV mucosal vaccines prior to clinical evaluation.

最近，我们已经设计了两种粘膜HIV疫苗策略，其在疫苗接种部位暂时阻断类IL-4/IL-13分子，从而在小动物中诱导具有保护功效的优异抗体和杀伤T细胞免疫。本项目旨在对这些新型HIV粘膜疫苗的安全性和有效性进行临床评价。